Sleep apnea pill shows striking success in large clinical trial
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Re: Sleep apnea pill shows striking success in large clinical trial
#2[deleted]
Re: Sleep apnea pill shows striking success in large clinical trial
#3>Atomoxetine also increases heart rate and diastolic blood pressure a little bit,
I believe most people with Sleep Aonea tend to have High Blood Pressure, this could be concerning.
Re: Sleep apnea pill shows striking success in large clinical trial
#4I worry about developing sleep apnea, not only for the effects on my health, but also on my relationship with my partner.
A medicine that treated sleep apnea would be revolutionary for so many people.
Re: Sleep apnea pill shows striking success in large clinical trial
#5>Atomoxetine also increases heart rate and diastolic blood pressure a little bit, I believe most people with Sleep Aonea tend to have High Blood Pressure, this could be concerning.
We have numerous good options to deal with high blood pressure, I wouldn't say this is really a problem. Many people take medicine for high blood pressure and live the rest of their lives completely unhampered.
Re: Sleep apnea pill shows striking success in large clinical trial
#6[flagged]
Re: Sleep apnea pill shows striking success in large clinical trial
#7I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses).
Looks like they buried the lede:
> possible side effects from atomoxetine such as signs that sleep isn’t as restorative while on AD109 or an increase in blood levels of C reactive protein [..] “Atomoxetine also increases heart rate and diastolic blood pressure a little bit,”
That's ... unsettling. So you're reducing events at the cost of increased blood pressure and heart rate? That's not good.
> the treated participants experienced 56% fewer instances during sleep where their breathing grew shallow or ceased
That sounds impressive at face value, but is probably pointless? So you have an AHI of 40, and now you have an AHI of 18? You're still getting crap sleep. Correctly titrated CPAP reduces events by ~99%.
> In addition, 22% of the treated patients achieved complete control of the disease, defined as fewer than five airway obstructing events per hour.
That sounds much better. Can these 22% be identified based on some criteria? So that they can be treated in this way?
> AD109 caused a “meaningful” reduction in the depth and duration of patients’ periods of low blood oxygen
"Meaningful"? If there is any significant saturation, your sleep is going to be shit. Again, correctly titrated CPAP eliminates desaturation entirely.
As far as I can tell, there's no polysomnography data to be examined anywhere. How was this tested? Are they just looking at AHI? In which case this is meaningless. Are these folks' sleep architectures restored? Or are they still having a bunch of events during REM which renders their REM sleep useless?
[1] https://www.cpaponline.com.au/wp-content/uploads/2020/05/cpa...
Re: Sleep apnea pill shows striking success in large clinical trial
#8>Atomoxetine also increases heart rate and diastolic blood pressure a little bit, I believe most people with Sleep Aonea tend to have High Blood Pressure, this could be concerning.
We have numerous good options to deal with high blood pressure, I wouldn't say this is really a problem. Many people take medicine for high blood pressure and live the rest of their lives completely unhampered.
Many people don’t take them nor do they want the side effects, so of course it’s a problem.
Every heart attack story I know of off the top of my head involves a man who didn’t want to take his blood pressure meds.
Re: Sleep apnea pill shows striking success in large clinical trial
#9>Atomoxetine also increases heart rate and diastolic blood pressure a little bit, I believe most people with Sleep Aonea tend to have High Blood Pressure, this could be concerning.
We have numerous good options to deal with high blood pressure, I wouldn't say this is really a problem. Many people take medicine for high blood pressure and live the rest of their lives completely unhampered.
> live the rest of their lives completely unhampered
Blood pressure medication has numerous side effects.
Increased blood pressure during sleep is the worst kind of hypertension ("reverse dipping").
Re: Sleep apnea pill shows striking success in large clinical trial
#10I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…
Do you wear a cpap?
It sucks. I have an OA now. And it also sucks.