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Sleep apnea pill shows striking success in large clinical trial

science.org

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Re: Sleep apnea pill shows striking success in large clinical trial

#11

Post by lm28469 »

Etheryte wrote: post #5
jmclnx wrote: post #3

>Atomoxetine also increases heart rate and diastolic blood pressure a little bit, I believe most people with Sleep Aonea tend to have High Blood Pressure, this could be concerning.

We have numerous good options to deal with high blood pressure, I wouldn't say this is really a problem. Many people take medicine for high blood pressure and live the rest of their lives completely unhampered.

Virtually any pill you have to take for life has negative side effects. Medicine made serious progress in all kind of ways but we don't have magic pills yet, even simple things like fixing a broken bone "only" has a 90-95% success rate without complications.

Stay in shape, eat clean an exercise, once it's gone it's gone for good

Re: Sleep apnea pill shows striking success in large clinical trial

#12

Post by elric »

dsego wrote: post #6

[flagged]

You're not wrong, in that this is proper tongue posture. But that's not going to cure sleep apnea. Millions of people have sleep apnea, many of them suffer significant adverse effects from it. Silly little aphorisms like this really aren't helpful to these people.

Re: Sleep apnea pill shows striking success in large clinical trial

#13

Post by elric »

balls187 wrote: post #10
elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

Do you wear a cpap? It sucks. I have an OA now. And it also sucks.

I do. It's not the greatest, but you get used to it, and it makes sleep a hell of a lot better.

Re: Sleep apnea pill shows striking success in large clinical trial

#14

Post by elric »

gp wrote: post #4

I worry about developing sleep apnea, not only for the effects on my health, but also on my relationship with my partner. A medicine that treated sleep apnea would be revolutionary for so many people.

> also on my relationship with my partner

That's not really much of an issue. There's an adjustment period, and there's a bit of an art to finding an appropriate mask. One that fits perfectly fine for you might have an exhaust port that blows air in your partner's face. Or the one that your partner can't hear at all might sound thunderously loud in your ears.

But all in all, your partner would much rather have you sleep with a mask than choke all night.

Re: Sleep apnea pill shows striking success in large clinical trial

#15

Post by refurb »

It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial.

And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. Seems like taking a stimulant might cause insomnia in some patients.

> In addition, 22% of the treated patients achieved complete control of the disease, defined as fewer than five airway obstructing events per hour.

This surprised me - 5 obstructive events per hour is "complete control of the disease"?

It looks like this is the clinical trial: https://clinicaltrials.gov/study/NCT05813275

Re: Sleep apnea pill shows striking success in large clinical trial

#16

Post by yetihehe »

gp wrote: post #4

I worry about developing sleep apnea, not only for the effects on my health, but also on my relationship with my partner. A medicine that treated sleep apnea would be revolutionary for so many people.

There are already nasal and throat sprays that help. I use throat spray and it helps a lot for getting better sleep for me and wife.

Re: Sleep apnea pill shows striking success in large clinical trial

#18

Post by rowanseymour »

I've had problems with obstructive sleep apnea for a couple of years. Tried CPAP/BPAP for a month and hated it so much I'm now trying to see what I can fix with surgery even though surgeries like maxilofacial sound horrific. I currently have a MARPE device installed to slowly splitting my palate bone down the middle to expand that. A pill sounds wonderful..
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