Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Baby is healed with first personalized gene-editing treatment

nytimes.com

Post reply on HN
Print view View original

541–550 of 570 posts

Re: Baby is healed with first personalized gene-editing treatment

#541

Post by floam »

mike_hearn wrote: post #536
heavyset_go wrote: post #514

Earlier quoted context omitted.

Toxicity depends on dose. COVID vaccines just need micrograms of material to induce an immune response, I imagine it takes more than that to edit the genes of a large organ.

There have sadly been cases where the vaccines did perform unintended gene editing. It shows up as people whose bodies are still producing spike protein months or years after vaccination.

Are you saying that there are cases of longer than expected spike protein presence where these cases are actually because gene editing took place?

Re: Baby is healed with first personalized gene-editing treatment

#542

Post by ColonelPanek »

Not quite. The child still has the disease and will need lifelong treatment for not only the disease itself, but also the gene editing procedure.

This procedure costing upwards of $800,000 simply trades one disease process for another.

It would be interesting to find out if this child does indeed end up getting the liver transplant that was sidelined for this new one off procedure.

Re: Baby is healed with first personalized gene-editing treatment

#543

Post by morepedantic »

philsnow wrote: post #433
efilife wrote: post #210

Earlier quoted context omitted.

I understand this. My question arose from the fact that it seems like he only cares about the child dying before him, not the child's death overall. It was > the idea of being told my 1 week old baby is going to die not > the idea of my child dying

It’s less of > my baby is going to die, woe is me and more of > have I failed my baby so much as a parent that he won’t even grow to adulthood (much less have a wonderful, happy life) It’s not exactly a rational feeling; it’s not like this baby was going to die through lack of parental effort or care or anything else that the parents have any real control over, so it’s not like they could have done anything different…

>It’s not exactly a rational feeling

It only looks irrational if you don't understand what people and feelings are.

Re: Baby is healed with first personalized gene-editing treatment

#544

Post by mike_hearn »

floam wrote: post #541
mike_hearn wrote: post #536

Earlier quoted context omitted.

There have sadly been cases where the vaccines did perform unintended gene editing. It shows up as people whose bodies are still producing spike protein months or years after vaccination.

Are you saying that there are cases of longer than expected spike protein presence where these cases are actually because gene editing took place?

The Yale LISTEN study found such people for example. Studies on post vaccination heart damage also found free spike protein in the blood of those affected, i.e. the body had turned off the immune response to the spike due to persistent internal production. The most likely way this happened is understood if you dig into it.

Re: Baby is healed with first personalized gene-editing treatment

#545

Post by amendegree »

thrance wrote: post #532
amendegree wrote: post #480

Earlier quoted context omitted.

The complete lack of self awareness is always breathtaking. Demanding empathy from others while being completely incapable of it yourself is always a stunning thing to encounter.

Do not mistake legitimate grievances for a lack of empathy. It's entirely on republicans to stop being so racist and vile to recover the rest of the population's respect. See also: the paradox of intolerance.

Ah yes, the “I can’t be wrong because they’re clearly evil and the cause of all the world’s ills” argument. Sounds so familiar…

Consider that everyone sees themselves as the hero… but that doesn’t mean you actually are, maybe, just maybe you are just as culpable as the person you’re accusing.

Re: Baby is healed with first personalized gene-editing treatment

#546

Post by thrance »

amendegree wrote: post #545
thrance wrote: post #532

Earlier quoted context omitted.

Do not mistake legitimate grievances for a lack of empathy. It's entirely on republicans to stop being so racist and vile to recover the rest of the population's respect. See also: the paradox of intolerance.

Ah yes, the “I can’t be wrong because they’re clearly evil and the cause of all the world’s ills” argument. Sounds so familiar… Consider that everyone sees themselves as the hero… but that doesn’t mean you actually are, maybe, just maybe you are just as culpable as the person you’re accusing.

Note that you could use your objection to defend nazism too. You can't "moral relativism" everything.

Republicans are currently the ones undermining the foundations or our republic, stripping rights from minorites (Texas just passed a bill that made it illegal to be trans), deporting people with no due process, arresting dissenting politicians and academics.

They're the ones plunging this country into economical ruin, destroying medicare and medicaid to transfer the savings to the 1% through massive tax cuts while letting everyone that depended on these programs die.

Everyone in support of these ideas is intolerant in my book, and I don't see why I should show empathy to a people that would rather see me in a camp.

Re: Baby is healed with first personalized gene-editing treatment

#547

Post by karagenit »

mike_hearn wrote: post #544
floam wrote: post #541

Earlier quoted context omitted.

Are you saying that there are cases of longer than expected spike protein presence where these cases are actually because gene editing took place?

The Yale LISTEN study found such people for example. Studies on post vaccination heart damage also found free spike protein in the blood of those affected, i.e. the body had turned off the immune response to the spike due to persistent internal production. The most likely way this happened is understood if you dig into it.

Do you have a citation for this? The only relevant study I saw on the LISTEN website was a preprint of a study showing data on self-reported post-vaccine symptoms, but didn’t really talk about causes or gene edits (Krumholz et al. 2023).

Re: Baby is healed with first personalized gene-editing treatment

#548

Post by mike_hearn »

karagenit wrote: post #547
mike_hearn wrote: post #544

Earlier quoted context omitted.

The Yale LISTEN study found such people for example. Studies on post vaccination heart damage also found free spike protein in the blood of those affected, i.e. the body had turned off the immune response to the spike due to persistent internal production. The most likely way this happened is understood if you dig into it.

Do you have a citation for this? The only relevant study I saw on the LISTEN website was a preprint of a study showing data on self-reported post-vaccine symptoms, but didn’t really talk about causes or gene edits (Krumholz et al. 2023).

It did discuss causes to some surface level: continuous spike protein production, T-cell exhaustion and Epstein-Barr reactivation. And they're investigating post-vaccine syndrome so the root cause there would be clear, as the study authors discussed in the LISTEN press release.

It's easy to find papers discussing the problem, just search Google Scholar. Example:

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp...

Integration was proven in 2024, unfortunately :(

https://www.medrxiv.org/content/10.1101/2024.03.24.24304286v...

"Of the S1 positive post-vaccination patients, we demonstrated by liquid chromatography/ mass spectrometry that these CD16+ cells from post-vaccination patients from all 4 vaccine manufacturers contained S1, S1 mutant and S2 peptide sequences"

They can tell the difference between vaccine spike and virus spike as the vaccine spike was modified for stability. The exact pathway is speculated to have been DNA contamination due to manufacturing process defects. Sequencing of vaccine vials has shown far higher levels of DNA contamination than is considered safe, and the lipids would bring DNA into the cells just as well as they do mRNA making the safe levels much lower still.

https://osf.io/b9t7m_v1/download/

Re: Baby is healed with first personalized gene-editing treatment

#549

Post by bratwurst3000 »

mike_hearn wrote: post #548
karagenit wrote: post #547

Earlier quoted context omitted.

Do you have a citation for this? The only relevant study I saw on the LISTEN website was a preprint of a study showing data on self-reported post-vaccine symptoms, but didn’t really talk about causes or gene edits (Krumholz et al. 2023).

It did discuss causes to some surface level: continuous spike protein production, T-cell exhaustion and Epstein-Barr reactivation. And they're investigating post-vaccine syndrome so the root cause there would be clear, as the study authors discussed in the LISTEN press release. It's easy to find papers discussing the problem, just search Google Scholar. Example: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.100…

> A significant limitation of this study was the lack of approved testing to 100% rule out previous infection and it is possible the persistent S1 protein detected in the CD16+ monocytes of some of the patients in this study is from SARS-CoV-2 and not from the vaccine. There also exists the possibility that some of these new-onset symptoms post-COVID vaccination are unrelated to the vaccines. The data from this study also cannot make any inferences on epidemiology and prevalence for persistent post-vaccine symptoms. Thus, further studies and research need to be done to understand the risk factors, likelihood and prevalence of these symptoms.

https://www.medrxiv.org/content/10.1101/2024.03.24.24304286v...

But yes further study has to be made.

Re: Baby is healed with first personalized gene-editing treatment

#550

Post by Muromec »

kulahan wrote: post #524
wffurr wrote: post #516

Earlier quoted context omitted.

I'd encourage you to read the article. Chemical weapons are effectively useless against a well-trained "modern system" army. Part of that is the chemical warfare equipment and vehicles, but mostly it's cover-and-concealment. If you can actually find the enemy, it's much faster and simpler to use the other vastly destructive munitions that modern militaries have.

I did, and it’s really not very convincing at all. It uses an example where a terror group in Japan was able to injure thousands of people with a chemical attack, and act as if this is… not a particularly effective outcome? Additionally, that “if you can find them” is doing some pretty heavy lifting. The range of explosives and kinetics is hilariously low, and the actual percentage of your military with the level of…

>I did, and it’s really not very convincing at all. It uses an example where a terror group in Japan was able to injure thousands of people with a chemical attack, and act as if this is… not a particularly effective outcome?

Yes, it isn't effective outcome in terms of meeting their objective

> It also doesn’t get into detail with concepts like dropping a bomb right in the middle of a firefight knowing it literally cannot harm your own troops

That's a video games logic, it doesn't work like that in practice. Even civil grade riot control tear gas grenade is pretty traumatic because it still explodes to disperse the gas (source : implied first hand knowledge). That and warfare is messy, which means half the time half the protective gear will be destroyed from the usual exploding and shooting happening, gas gets carried away by the wind in a random direction, etc, etc.

Post reply on HN