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Not only a hurtful question, but a stupid one as well. Well done.
Baby is healed with first personalized gene-editing treatment
201–210 of 570 posts
Re: Baby is healed with first personalized gene-editing treatment
#202Earlier quoted context omitted.
I suppose a downside (depending on your perspective) of this is that it will make people who are genetically modified in this fashion trivial to detect. That's good if your goals are to detect genetic modification which may be considered cheating in competitive sports. That's bad if your goals are to detect genetically modified people and discriminate against them. I see a near future where the kind of people who loa…
If you're going to make the comparison with vaccines, and if history is any indication, the more realistic worry would be the other way around (since that's where the money is): that genetic modifications will be mandated, and that those who object will be discriminated against. [And no, I am not anti-vax, nor anti-gene-editing.]
“What do you mean you haven’t modified your chromosome 7 CFTR gene? And you’re planning to have children???”
Re: Baby is healed with first personalized gene-editing treatment
#203[flagged]
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Re: Baby is healed with first personalized gene-editing treatment
#204> To accomplish that feat, the treatment is wrapped in fatty lipid molecules to protect it from degradation in the blood on its way to the liver, where the edit will be made. Inside the lipids are instructions that command the cells to produce an enzyme that edits the gene. They also carry a molecular GPS — CRISPR — which was altered to crawl along a person’s DNA until it finds the exact DNA letter that needs to be c…
I literally said the same thing out loud.
I had heard about CRISPR a while back but most reporting on it kind of hand waved over the mechanisms of how it actually accomplishes its work. What these researchers have figured out to make this work absolutely blows my mind.
Re: Baby is healed with first personalized gene-editing treatment
#205> To accomplish that feat, the treatment is wrapped in fatty lipid molecules to protect it from degradation in the blood on its way to the liver, where the edit will be made. Inside the lipids are instructions that command the cells to produce an enzyme that edits the gene. They also carry a molecular GPS — CRISPR — which was altered to crawl along a person’s DNA until it finds the exact DNA letter that needs to be c…
How does it know how to gps around? From what I know everything down there is a chemical reaction with some minimal physical motion, but how do you program it to know where to change and what and how.
Re: Baby is healed with first personalized gene-editing treatment
#206I think it was here a few years ago that I read a comment saying that sick children will be the Trojan horse for normalizing gene editing of humans, because who could say no to sick children, right? Well, guess it's here now, so how long utill the eugenics wars start?
Well a sick child has been healed so that necessarily means we will have a war about it?
Re: Baby is healed with first personalized gene-editing treatment
#207> To accomplish that feat, the treatment is wrapped in fatty lipid molecules to protect it from degradation in the blood on its way to the liver, where the edit will be made. Inside the lipids are instructions that command the cells to produce an enzyme that edits the gene. They also carry a molecular GPS — CRISPR — which was altered to crawl along a person’s DNA until it finds the exact DNA letter that needs to be c…
How does it know how to gps around? From what I know everything down there is a chemical reaction with some minimal physical motion, but how do you program it to know where to change and what and how.
It’s more like a “ctrl+F” for DNA. Hopefully there’s only 1 match (the target site).
Re: Baby is healed with first personalized gene-editing treatment
#208> To accomplish that feat, the treatment is wrapped in fatty lipid molecules to protect it from degradation in the blood on its way to the liver, where the edit will be made. Inside the lipids are instructions that command the cells to produce an enzyme that edits the gene. They also carry a molecular GPS — CRISPR — which was altered to crawl along a person’s DNA until it finds the exact DNA letter that needs to be c…
One other fun part of gene editing in vivo is that we don't actually use GACU (T in DNA). It turns out that if you use Pseudouridine (Ψ) instead of uridine (U) then the body's immune system doesn't nearly alarm as much, as it doesn't really see that mRNA as quite so dangerous. But , the RNA -> Protein equipment will just make protiens it without any problems. Which, yeah, that's a miraculous discovery. And it was wel…
Is this a troll? Pseudouridine mRNA isn't gene editing.
Re: Baby is healed with first personalized gene-editing treatment
#209[flagged]
Re: Baby is healed with first personalized gene-editing treatment
#210Earlier quoted context omitted.
Genuinely don't know why this is edgy. I was trying to understand his logic
Having a child predecease you is one of the worst things that can happen to a person in general. This is a common sentiment in humans. The strange thing is that you mentioned you're trying to follow "logic." This is not logic. These are emotions.
I understand this. My question arose from the fact that it seems like he only cares about the child dying before him, not the child's death overall. It was
> the idea of being told my 1 week old baby is going to die
not
> the idea of my child dying