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Baby is healed with first personalized gene-editing treatment

nytimes.com

531–540 of 570 posts

Re: Baby is healed with first personalized gene-editing treatment

#531
I love how the last lines of the article read,

> “I don’t think this could have happened in any country other than the U.S.,” Dr. Urnov said. > “We all said to each other, ‘This is the most significant thing we have ever done.’”

And then in the Discover More section is this article:

> Lab Animals Face Being Euthanized as Trump Cuts Research

Re: Baby is healed with first personalized gene-editing treatment

#532

Earlier quoted context omitted.

I have the same rage. But it extends equally to those who voted them in and donated to their campaigns, including my own family members. They have created a huge rift in this country and I am still trying to figure out if I will forgive my family members and what they'd have to do to set us on a path towards reconciliation. When there's a contract in place to conduct pediatric cancer research, and the government deci…

The complete lack of self awareness is always breathtaking. Demanding empathy from others while being completely incapable of it yourself is always a stunning thing to encounter.

Do not mistake legitimate grievances for a lack of empathy. It's entirely on republicans to stop being so racist and vile to recover the rest of the population's respect.

See also: the paradox of intolerance.

Re: Baby is healed with first personalized gene-editing treatment

#533
post #530

Earlier quoted context omitted.

[flagged]

Please don't comment like this, no matter how bad the comment you're replying to. The guidelines apply to everyone equally: https://news.ycombinator.com/newsguidelines.html

My bad. I had been reading about how there's a frustration in the community that allistic people refuse to explain why such statements are wrong, and instead just repeat "you know what you did!" to people who genuinely don't.

I tried to be the one who didn't do that, but missed the mark. I'd delete it if I could.

Re: Baby is healed with first personalized gene-editing treatment

#534
post #150

Earlier quoted context omitted.

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I assign only the most nefarious motives to those clowns, but at least her govt profile is intact: https://www.lbl.gov/people/excellence/nobelists/jennifer-dou... The fact that this treatment "built on decades of federally funded research" is the scary part, given that such funding may disappear.

Hopefully only until the next administration.

Re: Baby is healed with first personalized gene-editing treatment

#535
post #83

Earlier quoted context omitted.

One other fun part of gene editing in vivo is that we don't actually use GACU (T in DNA). It turns out that if you use Pseudouridine (Ψ) instead of uridine (U) then the body's immune system doesn't nearly alarm as much, as it doesn't really see that mRNA as quite so dangerous. But , the RNA -> Protein equipment will just make protiens it without any problems. Which, yeah, that's a miraculous discovery. And it was wel…

Wow that could be also abused by some future covid-lab to bypass immunesystem and modify the DNA so the body disfunctions

Yeah, I mention this in some other comments that got greyed out.

Basically, the real deal technology here is the lipid bubbles that deliver the payloads to the right cells, not the base modification. You can go look at them, and a lot of other comments in this thread for more info on that tech.

TLDR: No way that anyone can bypass anything. These lipid bubbles are a miracle that they work at all; they're so unstable, it boggles the mind we can even use them to begin with. Doing any large scale DNA editing on an unsuspecting population would be so insanely expensive and difficult, I certain moving to the Moon would be cheaper.

Re: Baby is healed with first personalized gene-editing treatment

#536

Earlier quoted context omitted.

> on the grounds that vaccines are something you only need to take once so the toxicity issue could be dodged But we didn't take these vaccines once. We took many of them. Am I to understand a known side effect is liver toxicity for multiple doses?

Toxicity depends on dose. COVID vaccines just need micrograms of material to induce an immune response, I imagine it takes more than that to edit the genes of a large organ.

There have sadly been cases where the vaccines did perform unintended gene editing. It shows up as people whose bodies are still producing spike protein months or years after vaccination.

Re: Baby is healed with first personalized gene-editing treatment

#537
post #516

Earlier quoted context omitted.

I'd encourage you to read the article. Chemical weapons are effectively useless against a well-trained "modern system" army. Part of that is the chemical warfare equipment and vehicles, but mostly it's cover-and-concealment. If you can actually find the enemy, it's much faster and simpler to use the other vastly destructive munitions that modern militaries have.

I did, and it’s really not very convincing at all. It uses an example where a terror group in Japan was able to injure thousands of people with a chemical attack, and act as if this is… not a particularly effective outcome? Additionally, that “if you can find them” is doing some pretty heavy lifting. The range of explosives and kinetics is hilariously low, and the actual percentage of your military with the level of…

>> a terror group in Japan was able to injure thousands of people with a chemical attack

A terror attack on civilians is a lot different than modern militaries using them on each other.

Re: Baby is healed with first personalized gene-editing treatment

#538
post #527

[flagged]

We detached this comment from https://news.ycombinator.com/item?id=43998721 and marked it off topic. Please observe the guidelines, especially these ones: Be kind. Don't be snarky. Converse curiously; don't cross-examine. Edit out swipes. Comments should get more thoughtful and substantive, not less, as a topic gets more divisive. Please don't fulminate. Please don't sneer, including at the rest of the community. Ple…

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