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Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

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301–310 of 394 posts

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#301

Earlier quoted context omitted.

For non-technical people, terms like Machine Learning, Algorithm, Automation, AI, Neural Networks and 'Magical Powers' are synonymous.. Journalists, marketing teams, and executives choose whichever term generates the most hype and clicks.

I like to describe my job as a software engineer as "wizardry" to people. With the way LLMs are writing code, it's only getting closer to writing actual spells.

> "Formerly, when religion was strong and science weak, men mistook magic for medicine; now, when science is strong and religion weak, men mistake medicine for magic."

— Thomas Szasz

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#302
post #185

Since it is naturally occurring, it isn't patentable. Which means it is less likely that companies will develop a commercial product from it. Why pay to get FDA approval, if you don't get a government granted monopoly on it afterwards? This is one problem with using patents as the mechanism to incentivise development of medicine.

I feel like the natural occurring property makes it more likely a supplement company will bring it to market without FDA requirements. The path to market should be simpler from my understanding of this space, please correct me if that’s incorrect

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#303
post #259

Earlier quoted context omitted.

Lithium is a good counter. It is by far the best treatment for bipolar 1, and its cheap and easy to source. Prices for lithium carbonate and other lithium medicament's are not at all cheap, and there are not a lot of medical companies producing it. There has even been shortages. Instead antipsychotics have been pushed as a preferred treatment, even though the outcomes are worse than with lithium.

Lithium in dosages effective in treating a mood disorder is quite toxic (e.g., to the kidneys) so most of the price is probably to offset the risk of lawsuit awards.

With regular blood checks its not an issue. You can catch it before the kidneys take damage. Antipsychotics are literally neurotoxic (first gen atleast).

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#304
post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

> The study would not have been possible without the use of artificial intelligence to weed through dozens of proteins in a class called prohormones. I see we’re being fast and loose with the term “artificial intelligence”?

unfortunately, if you do anything computational, when you need to explain it to a journalist/public audience/young person you want to hire/investor/trendchasing early user, you are incentivized to call it "AI".

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#305
post #202

Earlier quoted context omitted.

Caffeine is an example. Coffee and energy drinks are doing well I'd say.

Caffeine is grandfathered in as a Generally Recognized as Safe food additive. If energy drink companies had to go through clinical trials with no patent protection for each drink formula, they wouldn't make them.

Isn't it relatively easy to sell anything "naturally occurring" as a supplement? I think there is very little regulation (of course if you want to claim it's a drug and presumably charge much more for it it's another matter).

Even synthetic research chemicals are generally legal as long as you add a "not for human consumption" label (and they aren't explicitly banned or analogous to other illegal/regulated drugs).

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#306
post #273

Earlier quoted context omitted.

If you're "cutting" as part of bulking and cutting, then obviously. But if you're going from obese to healthy, then your goal isn't to retain all your leg muscle, that's absurd. Your goal is to get to a healthy weight with overall balanced healthy muscle -- not disproportionately large legs. Nothing is "strictly superior". What is best depends on what your goals are. Bodybuilding and not being obese any more involve…

No this is absurd. The goal for anyone obese is to lose as much fat as sustainably possible. For any given rate of weight loss, losing a higher proportion of body fat is always better. This notion of "balanced" healthy muscle is one you've made up that no one else thinks of. I've been on fitness forums for well over a decade and have literally never seen a single case of this.

> The goal for anyone obese is to lose as much fat as sustainably possible.

Correct.

> For any given rate of weight loss, losing a higher proportion of body fat is always better.

That is in direct contradiction to your previous sentence. No, losing the higher absolute amount of body fat is better. While being sustainable healthy.

> I've been on fitness forums for well over a decade and have literally never seen a single case of this.

You may be on the wrong forums then. Most forums don't think all your days should be leg days.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#307
post #286

Earlier quoted context omitted.

I've always been very, very skeptical of this claim. If there's an actual natural, identified substance with huge benefits to people, it's going to go gangbusters and you're going to make a lot, LOT of money selling it, even if you're doing it via roadside lemonade stand. It feels like this claim is usually used to promote cures and treatments with extremely low quality RCTs backing their use as a sort of panacea. I…

Nitrous Oxide (laughing gas) is both significantly cheaper, and less risky than epidurals for reducing pain during childbirth. Yet, in the US, most hospitals don't even offer it as an option, and I think a major part of that is that patented epidurals have much higher margins, so that is what the medical suppliers push.

I doubt it. It's very commonly offered in the UK and while it's cheap and safe, based on what I've seen it's also not effective at all. Forget the same league, it's not even playing the same game as an epidural. An epidural is a drip of opioids right to your spine. Proper hardcore.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#308

Earlier quoted context omitted.

Please, if you write regexes like these, comment them... A great way to do it is to split them up by concatenating them across a bunch of lines, and put a brief explanation at the end of each non-obvious part (to the right, on the same line). Plus that also lets you indent within nested parentheses, making it that much more understandable. I'm baffled when I come across a file like this where the code itself is heavi…

Great advice that is a bit redundant with LLMs, no? They're pretty great at all forms of translation.

First, I don't want to waste time feeding something into an LLM that should be commented in the first place.

Second, not at all. An LLM can tell you how the regex works (hopefully). It can't tell you what each piece means in terms of the program's logic. Or at least not always and not reliably.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#309
post #155

Earlier quoted context omitted.

> The idea that an overweight person has "too much muscle" is nonsense. I think you've misunderstood GP. He's not saying they have too much muscle when they're overweight. He's saying that take that exact same amount of muscle, subtract a ton of fat from their upper bodies, then they have "too much muscle" as typically needed for their body mass. I don't agree with their phrasing, but the point isn't "nonsense."

> then they have "too much muscle" as typically needed for their body mass It's a leap to suggest that it's "good" to lose this muscle mass. If you're obese then it's good to lose fat. It's even better to do so while maintaining muscle mass.

Yeah that's obviously better. They really meant it's "not bad" rather than "good".

When people read "muscle loss" they think "oh it's going to make me weak and feeble".

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#310
post #94

Maybe this one relates more with the Americans because Ozempic became a trend there: Why are most people jumping on this drug? At least for me, besides all the cliches and stereotypes about the USA people, there's huge access to nutrition, gyms, surgical procedures, capital for buying healthy food, and medicine in general.

Americans are overweight. Our entire food chain is full of preservatives, carcinogens, and things that should not be consumed by living beings . I've spent small amounts of time in Europe, and each time literally just eating whatever junk food I wanted, I came home losing 10 or 20 pounds. The food outside of the US is just fundamentally better. Let's say you're a teenager and you want to buy yourself some soda, in Am…

> junk food I wanted, I came home losing 10 or 20 pounds.

Maybe you caught some bug or something?

> The food outside of the US is just fundamentally better.

Meh... I'm from Europe and it's about the same, if you are at least somewhat selective about what you eat (and it might be much harder and/or expensive to do that in some places).

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