211–220 of 394 posts
Since it is naturally occurring, it isn't patentable. Which means it is less likely that companies will develop a commercial product from it. Why pay to get FDA approval, if you don't get a government granted monopoly on it afterwards? This is one problem with using patents as the mechanism to incentivise development of medicine.
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Is that an anti-pattern to put the comment inside the function vs above
Function documentation goes inside functions in Python, explicitly making them self-documenting. That can then be automatically picked up by any other code (like tooling for automatically generating API documentation) formalized as PEP 257, https://peps.python.org/pep-0257 Python will literally assign the content of your docstring (a triple-quoted string at the start of a function) to a special double underscored ("d…
Maybe this one relates more with the Americans because Ozempic became a trend there: Why are most people jumping on this drug? At least for me, besides all the cliches and stereotypes about the USA people, there's huge access to nutrition, gyms, surgical procedures, capital for buying healthy food, and medicine in general.
I mean, they work for a lot of people all the time. But they’ve existed forever, and over the past 50 years the obesity epidemic has only gotten worse.
Clearly, just offering things as available to people is not a systematic solution to this.
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The problem is that fat, sick people lose a lot of weight and muscle mass and then become skinny and frail. It just puts you at risk of other medical issues. In older individuals this can cause decreased mobility and raise the risk of falls. Its well documented in medical literature, that's why people worry about it.
But my point is that this is no different from being skinny and frail in the first place . It has nothing to do with losing weight. Yes, that puts you at risk. That's why you should exercise, even if it just means daily walks. The point is, you're not winding up with too little muscle because you lost weight. If you're winding up with too little muscle, it's because you're not being physically active enough. If you'r…
Imagine someone eating only candy and pastries, but because they eat so huge amounts, they actually get a half-decent amount of protein. Then they decrease portion size with the help of appetite suppresants.
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Beautiful yet terrifying. I'm glad that regex isn't something I'll ever have to touch.
Regex is one of my favorite things to work with. It's surgery. I love having a very specific problem and a very sharp knife. What I hate is chasing down language or library bugs, or undocumented limitations. Of course I would hate it if I had never used it extensively. Its terseness is harder if you only have to pick it up occasionally.
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The drug does not directly affect muscle mass (unless you are already very lean), but heavy people are doing resistance training against their own body weight all the time, so they are strong in the absolute, even if not relatively. Weigh less and your muscles have it easier, so weaken, unless you keep them strong with exercise.
I’m not sure that’s exactly what’s happening with GLP-1 drugs. I lost 40 pounds very quickly on them and hurt my hip then my shoulder then my wrist. Felt like I was constantly getting muscle strains and random injuries. I started drinking a protein shake once a day and the random mysterious injuries stopped.
Maybe this one relates more with the Americans because Ozempic became a trend there: Why are most people jumping on this drug? At least for me, besides all the cliches and stereotypes about the USA people, there's huge access to nutrition, gyms, surgical procedures, capital for buying healthy food, and medicine in general.
Exercise is great for your health, but it generally has a negligible effect on weight loss because exercise doesn't actually consume that many calories. The biggest benefit of exercise on weight loss is the temporary exercise-induced anorexia that occurs in very high intensity workouts.
I get on the treadmill for 1 hour and consume 700 calories in that hour.
Heavy exercise also causes improved appetite and sleep regulation as it fixes your blood sugar levels. This leads to your demand for food and especially the worst kinds to paradoxically go down for most fat people (they were already eating too many calories)
Calories in and calories out shows that I will durably lose weight over a several month period with 1 hr on the treadmill every other day - a totally doable number for motivated people.
I swear to gosh that all the people who say “you can’t outrun your fork” are fatties.
The issue is that the willpower to exercise for most people is trash. Most people who claimed they did high impact exercise and didn’t see weight loss simply didn’t actually do high impact exercise.
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I've always been very, very skeptical of this claim. If there's an actual natural, identified substance with huge benefits to people, it's going to go gangbusters and you're going to make a lot, LOT of money selling it, even if you're doing it via roadside lemonade stand. It feels like this claim is usually used to promote cures and treatments with extremely low quality RCTs backing their use as a sort of panacea. I…
Caffeine is an example. Coffee and energy drinks are doing well I'd say.
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I've always been very, very skeptical of this claim. If there's an actual natural, identified substance with huge benefits to people, it's going to go gangbusters and you're going to make a lot, LOT of money selling it, even if you're doing it via roadside lemonade stand. It feels like this claim is usually used to promote cures and treatments with extremely low quality RCTs backing their use as a sort of panacea. I…
I'm skeptical of your claim because if there's any additional margin to be made doing it artificially, at big-pharma scale history shows that they plenty willing to squeeze every penny out that they can even if it's less effective/natural.
For example, there's a prescription engineered version of melatonin.
Melatonin is still a huge business.
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There is a huge conflation of cause and effect with respect to muscle mass and longevity. Low muscle mass is associated a broad swath of illnesses, low activity, and generally poor health. Muscle mass's power as a predictor is not the same as it's utility as an intervention.
As long as you're not using exogenous hormones, muscle mass can only be achieved with exercise that builds or preserves muscle. I'd say that's a pretty good predictor against frailty, which is strongly associated with mortality among the elderly.
Something being a good a good predicative indicator does not mean it is an effective intervention.