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Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

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Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#131
post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

Please, if you write regexes like these, comment them... A great way to do it is to split them up by concatenating them across a bunch of lines, and put a brief explanation at the end of each non-obvious part (to the right, on the same line). Plus that also lets you indent within nested parentheses, making it that much more understandable. I'm baffled when I come across a file like this where the code itself is heavi…

regex101.com is a lifesaver for parsing esoteric regexes after you've forgotten what they're supposed to do.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#132
post #64

Earlier quoted context omitted.

I’m not sure that’s exactly what’s happening with GLP-1 drugs. I lost 40 pounds very quickly on them and hurt my hip then my shoulder then my wrist. Felt like I was constantly getting muscle strains and random injuries. I started drinking a protein shake once a day and the random mysterious injuries stopped.

What you described doesn’t seem to be in conflict with what he described

If the muscles had been reducing in concert with the reduced musculature needs of my body I wouldn’t be injuring myself.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#133
post #126

Earlier quoted context omitted.

It's nearly always a side effect of weight loss, and it's a good thing. It's confusing how people act like it's bad. If you're obese, your legs are enormously strong with crazy amounts of muscle. Have you ever seen someone obese do leg presses at the gym? They can handle tons of weight. When you lose weight, you don't need all that extra muscle . If you're carrying around 180 lbs instead of 300 lbs on your frame, all…

I think the downside is that you don't just lose muscle in your legs and core, but rather you lose muscle mass all over. Yes, this is the expected result of calorie restriction but the issue is that when people lose a lot of weight without taking action to build and maintain muscle the amount of muscle loss they experience can cause other problems. Someone relying on a GLP-1 drug is often someone who isn't very activ…

> but rather you lose muscle mass all over.

Well, you lose weight all over. You lose fat in your arms and your shoulders don't need to be quite as strong. You lose weight on your face and your neck muscles don't need to be quite as strong. You lose more in your legs, but you're supposed to lose muscle mass all over.

> Someone relying on a GLP-1 drug is often someone who isn't very active at all.

Sure, but that's a completely separate issue. It doesn't have anything to do with weight loss. Being in good strong physical shape is great, but nobody should expect weight loss to magically result in strength. That's like thinking you can stop going to the gym but won't lose any of the muscle you'd previously built up. It's got nothing to do with weight loss though. It's got to do with the fact that you're not working out.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#135

Earlier quoted context omitted.

You'll love this one then! [0]: https://cardoni.net/parsing-proper-nouns-with-regex/

That regex detects things like "eeieiieeeiA __ 1 2 3__" as a proper noun. I'm confused by the decision to accept any number of leading [ei] and any number of trailing (?:\s+[_\d]+).

It only looks for a single leading “e” or “i”, not any number. I’m guessing those tweaks were added to capture specific proper nouns that weren’t captured by simpler “leading capital letter” regexes, like “iPad” or “eBay”.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#136

Is the muscle loss a side effect of the drug or of the weight loss?

It's nearly always a side effect of weight loss, and it's a good thing. It's confusing how people act like it's bad. If you're obese, your legs are enormously strong with crazy amounts of muscle. Have you ever seen someone obese do leg presses at the gym? They can handle tons of weight. When you lose weight, you don't need all that extra muscle . If you're carrying around 180 lbs instead of 300 lbs on your frame, all…

This is exactly why hand-to-hand combat instructors will tell you that fighting an obese person will go very differently than you might think it will.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#137
post #126

Earlier quoted context omitted.

I think the downside is that you don't just lose muscle in your legs and core, but rather you lose muscle mass all over. Yes, this is the expected result of calorie restriction but the issue is that when people lose a lot of weight without taking action to build and maintain muscle the amount of muscle loss they experience can cause other problems. Someone relying on a GLP-1 drug is often someone who isn't very activ…

> but rather you lose muscle mass all over. Well, you lose weight all over. You lose fat in your arms and your shoulders don't need to be quite as strong. You lose weight on your face and your neck muscles don't need to be quite as strong. You lose more in your legs, but you're supposed to lose muscle mass all over. > Someone relying on a GLP-1 drug is often someone who isn't very active at all. Sure, but that's a co…

The problem is that fat, sick people lose a lot of weight and muscle mass and then become skinny and frail. It just puts you at risk of other medical issues. In older individuals this can cause decreased mobility and raise the risk of falls. Its well documented in medical literature, that's why people worry about it.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#138

Is the muscle loss a side effect of the drug or of the weight loss?

It's nearly always a side effect of weight loss, and it's a good thing. It's confusing how people act like it's bad. If you're obese, your legs are enormously strong with crazy amounts of muscle. Have you ever seen someone obese do leg presses at the gym? They can handle tons of weight. When you lose weight, you don't need all that extra muscle . If you're carrying around 180 lbs instead of 300 lbs on your frame, all…

That is absurd. Muscle mass is a huge predictor of mortality and anyone who isn't actively strength training and maintaining higher levels of muscle would see a health benefit by doing so. The idea that an overweight person has "too much muscle" is nonsense.

The side affect of muscle loss from these glp-1 agonist drugs is a serious downside that everyone should be aware of and try to mitigate if they choose to take them.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#139

Earlier quoted context omitted.

Yes, it might be misinformation, but it's convenient misinformation, is that the idea? And yes, it's true that a source like wikipedia could be too, but that has to withstand scrutiny to remain on the site, no such checks or balances in AI.

It's clearly labeled as the output of Sonnet 3.7, not truth. We all need to apply our own critical analysis of anything we read, whether it's claimed to be from an LLM or from Wikipedia. The possibility of inaccuracy isn't a reason to withhold comment.

Yes, I'd rather have it cited as an unreliable source than uncited. Every human will happily regurgitate misinformation they've absorbed unknowingly, so it's not that much worse than a confident human comment with no real citation besides themself.

However, I also think it's valid to question what it adds to a conversation if someone is quoting it verbatim. Would we be happier if HN was like Quora and automatically added an AI response to everything?

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#140
post #98
post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

Is this AGI?

Ask Deepseek to generate a regex for detecting python import statements.
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