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The brain's waste clearing lymphatic system shown in people for first time

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Re: The brain's waste clearing lymphatic system shown in people for first time

#91

Post by jayGlow »

haccount wrote: post #45
rozab wrote: post #28

Earlier quoted context omitted.

I hadn't heard of this one before, it's also similar to the crucifix glitch in Peter Watts' Blindsight

Having read both Blindsight and Echopraxia I have to say the most impressive neurological takeaway from the books was the ability of my own brain to suspend critical thinking for long enough to enjoy the books. In retrospect the core concept can be paraphrased as: Self-awareness and consciousness in pigs is the only thing that prevents them from flapping their trotters fast enough to fly(to the moon).

I'm not getting your point? the book had some out there ideas but the core concept of consciousness not being necessary for intelligence seemed fairly reasonable.

Re: The brain's waste clearing lymphatic system shown in people for first time

#92

Post by [deleted] »

ClearAndPresent wrote: post #59
PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Paul's animation wasn't playing at an even rate for me, for some reason, so I created two video versions (8Hz and 12Hz) with the 16 second on/off period, starting with an off period, running for 254 seconds, as per the paper. These versions end with an an additional off period, as a 'cool down' from the flicker. Framerate of 24Hz differs from the 120Hz as presented in the paper, but here there is no 40Hz flicker atte…

[deleted]

Re: The brain's waste clearing lymphatic system shown in people for first time

#93

Post by fny »

jdthedisciple wrote: post #11
PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

It seems to have no effect on me. Am I an outlier?

Why do you assume you're supposed to feel an immediate effect?

Increased CSF flow aids in clearing metabolic waste, distributing nutrients, and reduced oxidative stress. You'll feel none of this after a 3 minute session.

A lot of the reactions here reek of placebo.

Re: The brain's waste clearing lymphatic system shown in people for first time

#94

Post by Karellen »

shagie wrote: post #75
hobs wrote: post #47

Earlier quoted context omitted.

Charles Stross who for some reason posted on usenet about it in the wikipedia article uses a form of this to great effect in several books in The Laundry Files

Accelerando : https://www.antipope.org/charlie/blog-static/fiction/acceler... Not everything is sweetness and light in the era of mature nanotechnology. Widespread intelligence amplification doesn't lead to widespread rational behavior. New religions and mystery cults explode across the planet; much of the Net is unusable, flattened by successive semiotic jihads. India and Pakistan have held their long-awaited nuclea…

(2005)

Re: The brain's waste clearing lymphatic system shown in people for first time

#95

Post by briankirby »

PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Thanks so much for creating and sharing this! Could you point me to any other independent research in this area? Also, as I read related journal articles, I'm trying to understand if the 40Hz sound is binaural (with a 40Hz difference between frequencies in each ear) or a straight 40Hz pulse (same in both ears). It's surprisingly hard for me to get a clear answer. Do you happen to have any experience with this or suggestions for related resources that might contain the answer? Thanks!

Re: The brain's waste clearing lymphatic system shown in people for first time

#96

Post by teagoat »

sharpshadow wrote: post #65
mfro wrote: post #57

Earlier quoted context omitted.

> Glymphatic transport is most efficient in the right lateral sleeping position https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/ Section 3.4.3

Yes that’s the position. Good to see it verified in the study. Having a partner and sleeping in the same bed can lead to alterations from the optimal sleeping position, especially sleeping on the back is not good. Sleeping on the back is also one of the main causes of snoring, which often occurs in people which have a big belly and can’t really sleep lateralish anymore. Sleep quality is important too and one big fact…

Is increased glymphatic clearance good or bad?

Re: The brain's waste clearing lymphatic system shown in people for first time

#97

Post by feoren »

shaganer wrote: post #33
feoren wrote: post #19

Earlier quoted context omitted.

Staring at the v0.3 produces an effect similar to something I'm able to do trigger manually on command. I've always had the feeling that I'm somehow triggering a "flow" in my brain, but I have no way to confirm what's actually going on. It's actually stronger when I trigger it manually, and it feels like it flows down my spine and eventually some weak signal reaches my extremities. (Maybe that means it's not CSF afte…

I'm interested in how you accomplish this. I can do something along the lines of that by getting myself heated. I actually get a hothead and a tingling comes up to my brain like it's passing in a channel. It could simply be a sensation rising within the brain though, without an actual transport of something. I can focus better after but it doesn't clear my head, just use that frustration or anger to become determined…

I'm not quite sure exactly what I'm doing; it feels a bit like tensing a muscle, but that muscle feels like it's in the middle of my head, a bit toward the back. Obviously there are no actual muscles there, so I'm not sure what's actually happening.

If you try raising one eyebrow or wiggling one ear (assuming you can't already do that), you might find that you're briefly activating lots of little muscles around the target as your body tries to figure out where that's mapped in your brain. Once you get the right muscle, you can relax the other false positives, and eventually just have the single muscle isolated. It's similar in my "brain flow" thing: usually a couple random muscles in my head want to join in, but I can intentionally relax them and keep the "flow" going. A common one is the tensor tympani -- the two "muscles" seem to be closely mapped together. If you can rumble your ears (manually activating the tensor tympani), try initiating a rumble, and then "move" the activation in between your ears, right to your mid-back brain. (Again: I know there's no actual muscle there, so /shrug).

Re: The brain's waste clearing lymphatic system shown in people for first time

#98

Post by feoren »

assadk wrote: post #27
feoren wrote: post #19

Earlier quoted context omitted.

Staring at the v0.3 produces an effect similar to something I'm able to do trigger manually on command. I've always had the feeling that I'm somehow triggering a "flow" in my brain, but I have no way to confirm what's actually going on. It's actually stronger when I trigger it manually, and it feels like it flows down my spine and eventually some weak signal reaches my extremities. (Maybe that means it's not CSF afte…

How have you trained yourself to do that?

I'm not 100% sure, but it's something like this:

If you try raising one eyebrow or wiggling one ear (assuming you can't already do that), you might find that you're briefly activating lots of little muscles around the target as your body tries to figure out where that's mapped in your brain. Once you get the right muscle, you can relax the other false positives, and eventually just have the single muscle isolated. It's similar in my "brain flow" thing: usually a couple random muscles in my head want to join in, but I can intentionally relax them and keep the "flow" going. A common one is the tensor tympani -- the two "muscles" seem to be closely mapped together. If you can rumble your ears (manually activating the tensor tympani), try initiating a rumble, and then "move" the activation in between your ears, right to your mid-back brain. (Again: I know there's no actual muscle there, so /shrug). Another closely mapped muscle, at least for me, is a small one around/under/behind the ears that has a "face tightening" effect. It's like there are three muscles conceptually mapped to similar brain space: one tightens my ears/eyes/temples, one rumbles my tensor tympani, and one induces a feeling of "flow" down my spine and through my brain.

Re: The brain's waste clearing lymphatic system shown in people for first time

#99

Post by ToDougie »

rozab wrote: post #28
reverius42 wrote: post #13

Earlier quoted context omitted.

Thanks for introducing me to the concept! Just read the short story I assume you are referring to: https://www.infinityplus.co.uk/stories/blit.htm

I hadn't heard of this one before, it's also similar to the crucifix glitch in Peter Watts' Blindsight

Fantastic book. Really made me think in some new ways.

Re: The brain's waste clearing lymphatic system shown in people for first time

#100

Post by pedalpete »

PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

The 40hz visual + auditory stimulation is showing to be surprisingly effective in mice and humans. [1] When I first heard this, I thought the open-loop nature, and the fixed frequency across subjects sounded improbable, but I'm happy to be proven wrong.

We work in the neurotech/sleeptech space doing slow-wave enhancement which, it is believed, increases glymphatic activity [2]. Recent studies have looked at the promise of alzheimer's prevention [3].

More links to research papers are on our website https://affectablesleep.com/science

[1] - https://www.nature.com/articles/s41586-024-07132-6 [2] - https://www.frontiersin.org/journals/neuroscience/articles/1... [3] - https://pmc.ncbi.nlm.nih.gov/articles/PMC10758173/

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