Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

How long til we're all on Ozempic?

asteriskmag.com

Post reply on HN
Print view View original

981–990 of 1001 posts

Re: How long til we're all on Ozempic?

#981

Post by hyperG »

coffeebeqn wrote: post #817
cthalupa wrote: post #719

Earlier quoted context omitted.

Cagrilintide (paired with semaglutide) and retatrutide are the next wave, though I'm not aware of any research for either indicating an increase in muscle mass. My understanding of the literature is that there's nothing special about semaglutide or tirzepatide that promote muscle loss - it's just people who lose weight based purely on diet tend to also lose muscle mass. Even bodybuilders lose some muscle mass when cu…

Bodybuilders lose muscle and they do a lot of hypertrophy training and high protein eating to counteract it. Probably the average ozempic taker does neither of those so they end up losing more

There is a linear relationship between fat loss and caloric restriction until about 7 or 8% body fat.

The idea that caloric restriction is causing all this muscle loss is one of the dumbest ideas we currently have.

It is simply not true.

Re: How long til we're all on Ozempic?

#982

Post by skue »

gooosle wrote: post #980
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

You need to change your attitude if you want to lead a healthy lifestyle. Don't blame your failures and CHOICE to eat junk and not exercise on weed. You know what the healthy choices are, you know when you're not making them. You lack self control.

I don’t usually say something like this on HN, but you are completely and utterly wrong. The obesity epidemic cannot be reduced to some simple moral failure. Multiple twin concordance studies have shown 70%+ inheritability. Those of us who are fortunate enough to not struggle with obesity do so not because of some skillset that we have, but because our bodies do not maintain the same homeostasis.

For those of us old enough to remember what society looked like before the obesity epidemic kicked in, it’s hard to understand how something genetic can suddenly result in a dramatic change over a period of years. Our genetics didn’t change. Our food environment did. Experts disagree on what factors are responsible for this, and any random person had their own pet beliefs.

But this flat-earth-like notion of reducing obesity to an issue of basic willpower needs to be recognized for the drivel it is, along the related notion of calories in & calories out while ignoring the overwhelming role that basal metabolic burn plays and how it dynamically responds to changes in diet and exercise.

If you want to educate yourself, read Posner’s Burn [1], which is firmly grounded in empirical measurements of doubly labeled water to measure true metabolic consumption. Look up the reporting the NYT on past contestants of The Biggest Loser.[2]

[1] https://www.penguinrandomhouse.com/books/603894/burn-by-herm...

[2] https://www.nytimes.com/2016/05/02/health/biggest-loser-weig... (gift link)

Edit: Added links to sources.

Re: How long til we're all on Ozempic?

#983

Post by renegade-otter »

robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

I feel high on life when I am off the sauce, eat less, and walk more - without any drugs. Healthy lifestyle is the best medicine, and the biggest problem people have is not even genetic predisposition, it's impulse control. We all want that reward, right away.

Re: How long til we're all on Ozempic?

#984

Post by mycall »

robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

Have you looked at Psilocybin for your depression?

https://news.ycombinator.com/item?id=41818420

Re: How long til we're all on Ozempic?

#985

Post by profmarshmellow »

Rnonymous wrote: post #851
martin82 wrote: post #846

Don't think the hype will last long at all, since this ridiculous drug has extremely bad side effects, and works by enriching the body with millions of small fat cells that are all ready to blow up the moment you stop taking the drug. Or in orher words, it's a trap. If you take it, you have to take it forever and suffer extreme side effects, if you stop taking it, you will turn into a fat pig, worse than before, and…

What side effects? Blowing up fat cells? I was "find this page" for side effects, but see little discussion about them. So am honestly intrigued, and would love to hear more.

It disables your stomach... its like taking PPIs for gerd only to later find out the problem was low stomach acid and now your acid production capability has been permanently damaged by meds

Re: How long til we're all on Ozempic?

#986

Post by asyx »

vessenes wrote: post #313
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

Tirzepatide and Semaglutide are both known to reduce addiction / substance ingestion. I noticed I was just less interested in Alcohol when I started on Wegovy, and didn't realize it's a common effect until much later. I retained most of my disinterest after going off, too, FWIW.

I take mounjaro because I have T2 diabetes and it is a lot easier to stick to a diabetes appropriate diet. I was already normal weight and I lost 50kg 10 years ago but I could never really eat cleanly even after losing all that weight. The diabetes only improved that slightly.

Now, I can easily stick to a super low carb diet

Re: How long til we're all on Ozempic?

#987

Post by TeaBrain »

bronzekaiser wrote: post #756
knowitnone wrote: post #551

Earlier quoted context omitted.

one minute? I'm sure that's not going help anyone to walk for one minute. 30 minutes at a minimum. 60 is good, 120 is great!

most people dont have 2 hours a day to walk around in circles

I think most people actually would, if they would cut down on other time sinks in the evening.

Re: How long til we're all on Ozempic?

#988

Post by rangestransform »

Eumenes wrote: post #139

The day Ozempic/similar drugs become approved for weight loss under ACA/Medicare is the day I stop paying taxes.

It’ll cost less than the effects of obesity

Moral hazard has never been a good reason for any sort of regulation, the same principle can be used to justify not covering motorcycle riders, people who trad climb, people who do snow sports, people who jaywalk, people who work at a desk and drive everywhere, etc etc etc

Re: How long til we're all on Ozempic?

#990

Post by cthalupa »

jart wrote: post #957
hnburnsy wrote: post #801

Ozempic is just scratching the surface, the pipeline is bursting... >...combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the WL and cardiometabolic benefits of GLP-1 RA. I count 18 or so here... > https://www.nature.com/articles/s41366…

Thanks for sharing that link. Retatrutide looks especially promising since it targets three different receptors (GLP-1, GIP, and glucagon) instead of just GLP-1 like Ozempic. This triple action appears to have a more comprehensive effect on metabolism. So it may increase energy expenditure in addition to reducing calorie intake. This drug also showed significant improvements in lipid profiles, blood pressure, and liv…

There are some concerns with retatrutide - it's popular among the bolder people willing to buy it as a research chemical, and both their reports and the clinical trials do show significantly higher resting heart rates as a common side effect.

Not a huge deal for people that have good heart health already, but since obesity tends to cause poor heart health...

I expect we'll still get it approved for weight loss use, but it'll be one that is going to take more observation on the patients using it

Post reply on HN