Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

How long til we're all on Ozempic?

asteriskmag.com

Post reply on HN
Print view View original

601–610 of 1001 posts

Re: How long til we're all on Ozempic?

#601

Post by archsurface »

OptionOfT wrote: post #420

As someone who struggled with their weight his whole life, this medication is a god send. My wife and I cook every evening. We never eat food made in a factory. We buy raw products and spend a good amount of time every day cooking them. Every morning I wake up and go on a 5 mile hike. And still weight kept on coming on. Worse yet, I am on ADHD medication, which are amphetamines and actually make you lose weight. Yet.…

You mention types of food but not quantities. A boat load of healthy food is still going to have an effect. Also, I for one don't consider walking to be exercise. It's fake exercise for people who don't like exercise to claim they exercise. My reason is that I cycle for eight months of the year then walk during the rainy months. By the end of the rainy months I get back on the bike and my fitness level is catastrophic - nothing. I've done this for five years, and have to say walking is just not good enough for exercise, not even close.

Re: How long til we're all on Ozempic?

#602

Post by 0xcde4c3db »

I think we desperately need to answer the question of why GLP-1 agonists are so effective, and particularly whether it's counteracting something in the environment that has been acting to reduce GLP-1 (or other glucagon-related pathway) activity without us realizing it. The obesity data practically screams that something happened in North America ca. 1980 that messed up our metabolisms, and it may have spread to Europe after a delay. Unfortunately, it seems like one of those things where there are various people with pet theories and little substantial effort to get to the ground truth. Perhaps the inevitable search for "me-too drugs" will uncover something.

Re: How long til we're all on Ozempic?

#603

Post by sensanaty »

Uehreka wrote: post #271
farceSpherule wrote: post #237

A lot of people fail to realize that eating healthy and exercising is not enough for a lot of people who fight with their weight their entire lives. Ozempic and Wegovy are game changes and have real, tangible health benefits. One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs."

I gained about 50 pounds the past decade and the past year I’ve been trying to lose it. I weighed myself at the beginning: 205 lbs I started running 30 minutes per day (heartrate training targeting about 140-150), every day, for 10 months. I kept my diet the same as before (though with a protein bar after the run). Weighed myself every week or two, always within a couple pounds of 205. In March I ramped up my runs to…

Exercise by itself doesn't increase calorie burn all that much, it just strengthens your body in other ways. It's still very important, but to have a healthy weight you need to eat healthy (for most people this just translates to eating less) and diverse foods with good macro coverage.

You not changing your diet is the problem in this case, and that protein bar has so much sugar that by itself it's counteracting whatever effort the exercise had in the first place.

Also in my experience most people who say this kinda stuff (I train and eat healthy but can't lose weight!) actually don't eat healthy at all, because they simply don't know what that actually looks like.

Re: How long til we're all on Ozempic?

#604

Post by mrshadowgoose »

unclad5968 wrote: post #585
mrshadowgoose wrote: post #544

Earlier quoted context omitted.

> Why do we find it acceptable to help people who struggle with alcohol abuse, or nicotine addiction, or opioid addiction, but not to help people who struggle with food abuse? "Getting fit and staying fit" is a form of social capital, because it's extremely hard and only within reach of a small portion of the population. "Being fit" is strongly aligned with "being attractive" which confers all sorts of cross-cutting…

In what ways is fitness not within reach for a large portion of the population?

Studies have repeatedly shown that lifestyle modification does not result in sustained weight loss for most.

Not going to waste my time providing sources to remedy your ignorance. You are more than capable of doing this research yourself.

Re: How long til we're all on Ozempic?

#605

Post by rootusrootus »

nostromo wrote: post #558

For the longest time people argued if overweight people ate too much or not. I’ve heard plausible sounding arguments on both sides. It seems Ozempic has answered that question decisively, no? The solution to being overweight is eating less in almost all cases it seems. And feeling less hungry with Ozempic can help get you there.

> For the longest time people argued if overweight people ate too much or not.

Maybe uneducated people, but when was the last time anyone seriously doubted that excess calories make you fat? For serious people the discussion has always been about how to reduce the calories, because "just eat less" is provably ineffective. Simple minded people continuously suggest otherwise, but data really doesn't support their intuition at all.

Re: How long til we're all on Ozempic?

#606

Post by m0llusk »

WheelsAtLarge wrote: post #2

Statins are regularly given to people with high cholesterol. I would bet that most older people take or qualify to take a statin. If it happens with statins, therefore, it's not out of the realm to think that most people will eventually be prescribed GLP-1 to reduce weight which will improve overall health. It makes sense.

Statins are a good comparison because most end their use after one or two years because of the side effects.

Re: How long til we're all on Ozempic?

#607

Post by brianmcc »

archsurface wrote: post #601
OptionOfT wrote: post #420

As someone who struggled with their weight his whole life, this medication is a god send. My wife and I cook every evening. We never eat food made in a factory. We buy raw products and spend a good amount of time every day cooking them. Every morning I wake up and go on a 5 mile hike. And still weight kept on coming on. Worse yet, I am on ADHD medication, which are amphetamines and actually make you lose weight. Yet.…

You mention types of food but not quantities. A boat load of healthy food is still going to have an effect. Also, I for one don't consider walking to be exercise. It's fake exercise for people who don't like exercise to claim they exercise. My reason is that I cycle for eight months of the year then walk during the rainy months. By the end of the rainy months I get back on the bike and my fitness level is catastrophi…

To be fair OP did say:

>> And you know what it is? It's volume. I eat too much.

Re: How long til we're all on Ozempic?

#608

Post by philipkglass »

spondylosaurus wrote: post #548
apsec112 wrote: post #8

This compares Ozempic with past drugs, but sales of past drugs are almost always limited by demand. I'm not sure there's much to learn here for a drug that is limited by supply. Also, this part is silly: "The announced investments across both companies total $32 billion. GLP-1s were 71% of Novo’s revenue in 2023, 16% of Lilly’s in 2023, and 26% of Lilly’s in 2024Q1. If these sales are proportional to the manufacturin…

I'm shocked that TFA doesn't mention the (massive, booming) market for compounded semaglutide and tirzepatide. The long-term future is uncertain, but since these drugs have been under shortage status, third-party pharmacies can legally compound them to meet increased demand.

9 days ago the FDA declared the tirzepatide shortage over, though the other popular drugs in this class are still eligible for compounding based on shortage status:

https://www.fda.gov/drugs/drug-safety-and-availability/fda-c...

Re: How long til we're all on Ozempic?

#609

Post by SirMaster »

gcr wrote: post #229
dfxm12 wrote: post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

If you have an open mind, I'd like to assign you some homework if you like. Take a look around r/zepbound and count the following: 1. Posts from folks who diet+exercise, or who have tried diet/exercise and nothing's worked so they then turned to Zepbound ("excited to hit the gym," "my diet is finally starting to work with Zepbound" and similar) 2. Posts from folks who haven't tried diet/exercise and turned to Zepboun…

But don't you think that it's better to make the changes to prevent obesity rather than focus so much on a cure for after?

I don't have a problem with a cure only if it doesn't reduce the focus and effort on prevention.

There has to be a reason why so many more people are obese today than decades ago. I refuse to believe we can't find out why and make changes to reverse it.

But if it's so easy to cure, will enough people care about figuring out how to prevent it?

Re: How long til we're all on Ozempic?

#610

Post by brianmcc »

colordrops wrote: post #521
OptionOfT wrote: post #420

As someone who struggled with their weight his whole life, this medication is a god send. My wife and I cook every evening. We never eat food made in a factory. We buy raw products and spend a good amount of time every day cooking them. Every morning I wake up and go on a 5 mile hike. And still weight kept on coming on. Worse yet, I am on ADHD medication, which are amphetamines and actually make you lose weight. Yet.…

Have you every using a calorie/macro tracking app like My Fitness Pal or Cronometer? I was never successful losing weight until I scanned, weighed, and measured every single thing I put into my body and stuck to the target calories and macros entered into the app. Just being aware of exactly how much I was eating was often enough to find the motivation to control volume.

>> I scanned, weighed, and measured every single thing I put into my body

Not being snarky, but is this truly "better" than a single weekly injection - 10 seconds and done for the week? I do think our wider society sees medications for overeating as "cheating". Perhaps we might benefit from rethinking that.

Post reply on HN