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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#591

Post by connicpu »

cyberax wrote: post #564
connicpu wrote: post #252

Earlier quoted context omitted.

I'm curious what about injectables makes them specifically problematic for long term use? Diabetics already have to inject insulin for the rest of their lives, and an injectable version of the same drug usually has fewer side effects since it doesn't have to pass through your gut metabolism. I may be biased, I have no fear of needles and have injected myself with sex hormones every week for nearly 7 years, so adding…

They are more expensive. Autoinjectors are way more complicated than a pill bottle. You also can't freeze them, but they should be kept in a fridge. Manufacturing standards also have to be way higher. I have no problem trusting Novo Nordisk to manufacture injectors safely, but I won't trust a random manufacturer from India or China. The risk of accidental infection from injection also is not neglibible.

Fair considerations, I just disagree that it makes injections inherently problematic for long term use. Primarily because I have doubts about the possibility of a pill that doesn't come with more side effects than an equivalent injectable.

Re: How long til we're all on Ozempic?

#593

Post by arijo »

arijo wrote: post #586
kerbs wrote: post #579

Earlier quoted context omitted.

It is not easy on the mind and body as to just cut carbs.

I apologize for the shortcut - I should have given more context, though you can validate my assertion by going to this site: https://metabolicmind.org There is heavy research on the usage of the ketogenic diet for the treatment of metabolic and mental illness. I've written about my personal story here - https://www.feelingbuggy.com/p/finding-hope-after-decades-of...

I also recommend taking a look at this Joe Rogan interview to understand at a deep level all the problems with a drug like Ozempic - https://www.youtube.com/watch?v=G0lTyhvOeJs

Re: How long til we're all on Ozempic?

#594

Post by rootusrootus »

zonkerdonker wrote: post #39
wizzwizz4 wrote: post #20

Earlier quoted context omitted.

Source? https://www.mcgill.ca/oss/article/medical-critical-thinking/... (2023) disagrees with you: > Neither is berberine any version of Ozempic, which is an analogue of glucagon-like-peptide-1 (GLP-1), a natural hormone that regulates blood sugar and helps people feel full. Berberine has nothing to do with GLP-1. > Perhaps the most interesting laboratory finding, given the rising global tide of type 2 diabetes, is t…

I was able to find this: https://www.sciencedirect.com/science/article/abs/pii/S00062... . Apparently most of the effect is due to activation of the "bitter taste reception pathways" in the gut. So even though it has very low bioavailibility, it can still stimulate GLP-1 secretion just simply due to its incredible bitterness

Does it only stimulate GLP-1 in the gut, though? As I understand it, most of the positive effects of GLP-1 agonists are the effect they have on the brain's GLP-1 system, not the guts.

Re: How long til we're all on Ozempic?

#596

Post by tjohns »

spondylosaurus wrote: post #537
tjohns wrote: post #399

Earlier quoted context omitted.

Studies have show most people rapidly regain the weight once they stop taking GLP-1 drugs. The dysfunctional biochemical processes that contributed to overeating are still present if you discontinue the drug. Your body has a natural set-point for the weight it wants to be at, and the hunger and food noise comes right back as your body tries to get you back to your old weight. It's possible that after after a long eno…

"You'll regress if you stop taking the drugs" may be true, but it seems like a double standard to frame it as a knock against weight loss drugs when this also describes countless other interventions for chronic issues... Your lupus will flare up again if you stop taking Plaquenil! Your eyesight will be bad again when you take off your glasses!

I actually agree entirely.

I'm just being objective in stating that the evidence suggests that these drugs need to be taken long term to have lasting effects. Not everyone realizes this.

But I think that's okay if it can get people back down to a healthy weight. The health impact from being overweight is serious, and we know that lifestyle intervention has a stunningly abysmal success rate.

Anything we can do to reverse the obesity epidemic is a good thing.

Re: How long til we're all on Ozempic?

#597

Post by rootusrootus »

jaco6 wrote: post #56

I’m just as curious as to why some people are so willing to take numerous medications, while others go to any lengths to avoid them. Some people are happy to be on an SSRI, sleeping pill, statin, low dose aspirin, and a few others, and aren’t bothered by this. Other people seem instinctively revolted by prescription drugs, seeing toxins pushed by evil corporations. Is it a trust issue? I personally detest and avoid a…

> seeing toxins pushed by evil corporations. Is it a trust issue?

That sounds a lot like the divide between people who see conspiracies everywhere and those who do not. In that case I would suggest it is just personality, not logical and not solved by improving trust.

Re: How long til we're all on Ozempic?

#598

Post by adrian_b »

lukasb wrote: post #167
arcticbull wrote: post #105

Earlier quoted context omitted.

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

Are there any studies that look at body fat % instead of weight? I don't care how much I weigh.

A good proxy for body fat %, especially for males, is the waist circumference / hip circumference ratio.

See e.g.

https://en.wikipedia.org/wiki/Waist%E2%80%93hip_ratio

for recommended values.

Re: How long til we're all on Ozempic?

#599

Post by rootusrootus »

Blackthorn wrote: post #134
jaco6 wrote: post #56

I’m just as curious as to why some people are so willing to take numerous medications, while others go to any lengths to avoid them. Some people are happy to be on an SSRI, sleeping pill, statin, low dose aspirin, and a few others, and aren’t bothered by this. Other people seem instinctively revolted by prescription drugs, seeing toxins pushed by evil corporations. Is it a trust issue? I personally detest and avoid a…

Nobody ever gets sus about needing to take heart medication every day to stay alive but the moment it becomes about how I take Lexapro every day they get real preachy.

Maybe we can find a medication people will take that solves the preachy problem instead. That might achieve significant population-wide improvements.

Re: How long til we're all on Ozempic?

#600

Post by arijo »

dyauspitr wrote: post #376
vessenes wrote: post #313

Earlier quoted context omitted.

Tirzepatide and Semaglutide are both known to reduce addiction / substance ingestion. I noticed I was just less interested in Alcohol when I started on Wegovy, and didn't realize it's a common effect until much later. I retained most of my disinterest after going off, too, FWIW.

Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.

It's not a miracle drug. Check this Joe Rogan interview to understand at a deep level all the problems with a drug like Ozempic: https://www.youtube.com/watch?v=G0lTyhvOeJs
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