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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#31

Post by codingdave »

indiebat wrote: post #17

I don’t want this to come out insensitive or from under the rock, but why is taking a drug a novel & cool idea (all of a sudden/recently) as opposed to good old fashioned working out and not eating more than what you need? okay, this drug is all kinds of great and it’s the next best thing since green grapes, still not eating more and workout is better than taking drugs that effect your brain right? Are doctors requir…

Because not everyone has willpower and discipline. People who do have those strengths often think it is just as simple as saying, "Just take care of yourself", but it is not that easy for many people. High blood sugar also increases cravings, which makes it even harder, bringing on a downward spiral.

This drug can help break out of that spiral and fix the craving/willpower problems.

Re: How long til we're all on Ozempic?

#32

Post by andrewmcwatters »

kelseyfrog wrote: post #24
rqtwteye wrote: post #4

It's a pretty sad thought that everybody will be on a drug that keeps weight in check while most people will still eat a basically toxic diet. Weight is certainly an important factor but there is more to a healthy life.

From my understanding GLP-1 agonists can actually modulate the reward pathway reducing people's appetite for toxic diets. We're not socially caught up yet to this information. I suspect there are folks who believe that regardless of similar outcome (reduction of toxic diet), that changing diet without medication is superior to those who change their behavior through pharmacological intervention. It's like the pre-199…

You can literally do the same thing by eating a healthy diet for 2-4 weeks.

Re: How long til we're all on Ozempic?

#33

Post by xvedejas »

indiebat wrote: post #17

I don’t want this to come out insensitive or from under the rock, but why is taking a drug a novel & cool idea (all of a sudden/recently) as opposed to good old fashioned working out and not eating more than what you need? okay, this drug is all kinds of great and it’s the next best thing since green grapes, still not eating more and workout is better than taking drugs that effect your brain right? Are doctors requir…

Most people don't work out enough, or don't eat well enough. If we had some kind of intervention that would easily cause people to work out, we would use that intervention. If we had some kind of intervention that would easily cause people to eat well, we would use that intervention. The reason working out and good diet are good is because of good health outcomes. If we have some kind of intervention that skips straight to the good health outcomes, we would use that intervention. It seems like Ozempic is _that_ intervention, so we will use it. I will likely choose Ozempic for myself once it is available to me.

Re: How long til we're all on Ozempic?

#34

Post by gedy »

IncreasePosts wrote: post #3

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

Keep in mind a lot of people who'd benefit from this may not last another 30 years due to age or health issues due to weight either.

Re: How long til we're all on Ozempic?

#35

Post by philipkglass »

fredgrott wrote: post #9

for those that do not know there is a herb that targets GLP-1...its called Berberine And yes its over the counter....I currently take one dose per day at 1200mg

Interesting.

"Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways"

https://www.sciencedirect.com/science/article/pii/S000629521...

But buyer beware when it comes to getting berberine from over-the-counter supplements:

"Variability in Potency Among Commercial Preparations of Berberine"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807210/

Nine of the 15 tested products (60%) failed to meet the potency standards of 90% to 110% of labeled content claim, as commonly required of pharmaceutical preparations by the U.S. Pharmacopeial Convention. Evaluation of the relationship between product cost and the measured potency failed to demonstrate an association between quality and cost. Variability in product quality may significantly contribute to inconsistencies in the safety and effectiveness of berberine. In addition, the quality of the berberine product cannot be inferred from its cost.

Worse still,

"Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337101/

Berberine—an isoquinoline alkaloid isolated from the rhizome of Coptidis rhizome, Cortex phellodendri, and other plant species—possesses a variety of pharmacological effects, including anti-cancer, anti-hyperglycemic, anti-hyperlipidemic, antimicrobial, anti-inflammatory, and antioxidant activities. However, its absolute bioavailability is as low as 0.68%. Low bioavailability greatly restricts the clinical development of berberine.

Re: How long til we're all on Ozempic?

#36

Post by tredre3 »

setgree wrote: post #13

There's some evidence that Ozempic improves general impulse control, e.g decreasing alcohol consumption [0], which the article mentions. Also, as Tyler Cowen writes [1], this is probably going to translate into big improvements for animal welfare: > People lose weight on these drugs because they eat less, and eating less usually means eating less meat. And less meat consumption results in less factory farming. This s…

> big improvements for animal welfare

Is it? It might reduce the amount of animals killed, sure, but it won't improve the well-being of the ones that are still raised.

Re: How long til we're all on Ozempic?

#37

Post by Fernicia »

rqtwteye wrote: post #4

It's a pretty sad thought that everybody will be on a drug that keeps weight in check while most people will still eat a basically toxic diet. Weight is certainly an important factor but there is more to a healthy life.

Is it fundamentally any different from something like toothpaste?

Humans have created a technology (mechanised farming) with a side effect we haven't yet evolved to handle (an abundance of tasty calories), so it doesn't seem all that strange we would fix it with a technology (inhibiting the desire for said calories).

Re: How long til we're all on Ozempic?

#38

Post by lostmsu »

rqtwteye wrote: post #4

It's a pretty sad thought that everybody will be on a drug that keeps weight in check while most people will still eat a basically toxic diet. Weight is certainly an important factor but there is more to a healthy life.

I think your statement is very funny. If the drug keeps weight in check on a toxic diet and that has the same outcome as "healthy life", then is that "healthy life" any more healthy then the drug+junkfood combo? Also, what is sad about it?

Re: How long til we're all on Ozempic?

#39

Post by zonkerdonker »

wizzwizz4 wrote: post #20
fredgrott wrote: post #9

for those that do not know there is a herb that targets GLP-1...its called Berberine And yes its over the counter....I currently take one dose per day at 1200mg

Source? https://www.mcgill.ca/oss/article/medical-critical-thinking/... (2023) disagrees with you: > Neither is berberine any version of Ozempic, which is an analogue of glucagon-like-peptide-1 (GLP-1), a natural hormone that regulates blood sugar and helps people feel full. Berberine has nothing to do with GLP-1. > Perhaps the most interesting laboratory finding, given the rising global tide of type 2 diabetes, is t…

I was able to find this: https://www.sciencedirect.com/science/article/abs/pii/S00062....

Apparently most of the effect is due to activation of the "bitter taste reception pathways" in the gut. So even though it has very low bioavailibility, it can still stimulate GLP-1 secretion just simply due to its incredible bitterness

Re: How long til we're all on Ozempic?

#40

Post by gedy »

amatecha wrote: post #19

This article seems to frame things in such a strange way. Maybe instead of trying to get everyone obesity medication, we can instead educate society so we all understand nutrition and diet and can combat the ever-persistent forces of corporations pushing unhealthy food on us?

Look we've been educating people about this for the past 50 years at least - education doesn't work with base impulses.
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