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Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

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Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#101

Post by rahimnathwani »

petercooper wrote: post #83
smith7018 wrote: post #80

Earlier quoted context omitted.

Thank you for this, I've wanted to do genetic testing for years but don't want it to be stored on anyone's server. Can you explain how it's not stored on any server? Like, you're downloading the .BAM file from Nebula; doesn't that mean they hold onto the data?

Anyone who does the actual sequencing has the data. I think they mean the final service that does the analysis runs locally in the browser. You still need to trust whoever does the sequencing.

I think the point is to prevent the data from being linked to your identify (name, address etc.).

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#102

Post by rahimnathwani »

hiatus wrote: post #95
aantix wrote: post #86

Earlier quoted context omitted.

Nebula.org does the data sequencing. They support anonymous sequencing. https://nebula.org/anonymous-seq/ Genetic Life Hacks provides the analysis on a number of health and disease related topics. Their analysis is simply allele matching for any given topic (string comparisons). It's all done within the browser. https://www.geneticlifehacks.com/faqs-about-genetics/#:~:tex...

> They support anonymous sequencing. > https://nebula.org/anonymous-seq/ The button to purchase says "coming soon" for me.

Same for me (in the US).

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#103

Post by mapt »

aantix wrote: post #76

To determine whether you're a slow or fast caffeine metabolizer.. Wait for a sale at Nebula.org. Get your whole genome sequenced. ~$200. Having your whole genome sequenced could have added benefits down the road. Download the .BAM file. It will be several gigabytes. Use WSG Extract to generate the 23andMe raw data files. https://www.geneticlifehacks.com/convert-whole-genome-file/ Connect that data file to Genetic Lif…

When I think about sequencing, I think about verifiability. With anonymity blinkers on, you could give me several gigabytes of random data and I'd have limited recourse.

Will Nebula give me an intelligible whole-genome data file if I happen to be a Golden Retriever?

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#104

Post by idiliv »

aantix wrote: post #76

To determine whether you're a slow or fast caffeine metabolizer.. Wait for a sale at Nebula.org. Get your whole genome sequenced. ~$200. Having your whole genome sequenced could have added benefits down the road. Download the .BAM file. It will be several gigabytes. Use WSG Extract to generate the 23andMe raw data files. https://www.geneticlifehacks.com/convert-whole-genome-file/ Connect that data file to Genetic Lif…

Is the "Ultra Deep" analysis worth it over the standard "Deep" analysis?

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#105

Post by embwbam »

wnolens wrote: post #72
aantix wrote: post #69

Please take in to account slow vs fast caffeine metabolizer. "CYP1A2 Gene: Fast or Slow Caffeine Metabolizer?" https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/ This is one of those subjects where people argue past each "I can drink a cup of coffee and sleep like a baby!" vs "One cup of coffee in the morning and my sleep quality is impacted". And neither understands how the other can have a vastly different…

Oh wow, I'm surprised that this is not common knowledge given how common coffee is. I didn't even know it was a thing. File me under "A cup of coffee feels like a small dose of MDMA"

For anyone else who discovers they are a fast metabolizer of coffee: try eating a big breakfast before drinking coffee to slow absorption.

I wanted to be a coffee drinker for YEARS, but it made me really high, and I felt super tired later in the day. I don't know why I didn't connect the dots until I searched my genome, but once you know whether you are a fast or slow metabolizer you can play all sorts of games. I can now drink coffee before dinner, and the crash hits right at bedtime.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#106

Post by aantix »

mapt wrote: post #103
aantix wrote: post #76

To determine whether you're a slow or fast caffeine metabolizer.. Wait for a sale at Nebula.org. Get your whole genome sequenced. ~$200. Having your whole genome sequenced could have added benefits down the road. Download the .BAM file. It will be several gigabytes. Use WSG Extract to generate the 23andMe raw data files. https://www.geneticlifehacks.com/convert-whole-genome-file/ Connect that data file to Genetic Lif…

When I think about sequencing, I think about verifiability. With anonymity blinkers on, you could give me several gigabytes of random data and I'd have limited recourse. Will Nebula give me an intelligible whole-genome data file if I happen to be a Golden Retriever?

Totally understand.

Luckily I had previously completed 23andMe, so I could cross reference that data with that generated by Nebula/WSG Extract.

My caffeine metabolism did match up.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#107

Post by taeric »

aantix wrote: post #90
taeric wrote: post #88

Earlier quoted context omitted.

I'm curious if there is a basic set of tests you can do with drinking locally to know one way or the other, as well?

Measure your blood pressure. Measure before consumption. Take three different readings. Measure at one hour intervals after caffeine consumption. Fast metabolizers BP should return to baseline within a couple of hours. Mine would remain elevated for 10-12 hours.

I'm assuming elevated is purely relative to your baseline?

Oddly, I don't think my blood pressure changes much at all. Will try this test again, though.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#108

Post by alkh »

I had a similar idea to track my caffeine intake(assuming that the half-life is 6 hours). The only question I haven't had time to look into yet is what is the biological effect of previously taken vs newly taken caffeine? Say I had a cup of coffee at 9 am and then have another one at 9+6 hours=3 pm. Assume that 1 cup of coffee has 90 mg of caffeine. Does it mean that at that moment, I will have to track 2 different half-lifes? That is, I have 90/2=45 mg of caffeine from cup #1 and 90 mg of caffeine from cup #2 at 3 pm. Should I just add those up and track the combined amount now or should it be kept separate? I am leaning towards the latter because I think that the effect(i.e. alertness) will be higher with the newly digested caffeine and not the one taken 6 hours ago? No idea how true this is though as I am not a biologist :)

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#109

Post by tehjoker »

rahimnathwani wrote: post #101
petercooper wrote: post #83

Earlier quoted context omitted.

Anyone who does the actual sequencing has the data. I think they mean the final service that does the analysis runs locally in the browser. You still need to trust whoever does the sequencing.

I think the point is to prevent the data from being linked to your identify (name, address etc.).

Your identity can be reconstructed from relative's samples. If you submit your sequence its out of your hands forever. The only way to do this privately is to do the sequencing in your own lab.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#110

Post by onethumb »

Y_Y wrote: post #89
aantix wrote: post #76

To determine whether you're a slow or fast caffeine metabolizer.. Wait for a sale at Nebula.org. Get your whole genome sequenced. ~$200. Having your whole genome sequenced could have added benefits down the road. Download the .BAM file. It will be several gigabytes. Use WSG Extract to generate the 23andMe raw data files. https://www.geneticlifehacks.com/convert-whole-genome-file/ Connect that data file to Genetic Lif…

23andme has a "report" about this called Caffeine Consumption. The markers they use are rs4410790 and rs2472297, whereas geneticlifehacks.com talks about rs762551. I'm not sure what to make of that, since that second 23andme one is "near" cyp1a2. https://you.23andme.com/reports/wellness2.caffeine_consumpti...

This article seems to tie them together nicely: https://www.gbhealthwatch.com/Trait-Caffeine-Consumption.php
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