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Researchers find Alzheimer's-like brain changes in long Covid patients

uknow.uky.edu

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Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#91

Post by throwaway2037 »

sweeter wrote: post #58
fao_ wrote: post #48

Earlier quoted context omitted.

The reason for that is around 30 - 50 years of continual gutting of the NHS, aggressive implementation of perverse incentives and anti-targets (e.g. "hospitals get less money if they fail to meet X standard of care, because they do not have enough money"), and overloading of staff duties to reduce costs (e.g. Physicians now performing duties that receptionists used to handle, the lack of work force meaning they have…

typical austerity measures. The US and the UK power holders have massive incentives to privatize healthcare and schooling, so they de-fund and starve the beast with the sole purpose of trying to get people to support laws that turn public institutions into private ones. "a government small enough to drown in the bath water" With healthcare this is especially disastrous. In the US for example, most smaller towns don't…

    > The US and the UK power holders have massive incentives to privatize healthcare and schooling
This is quite a wide brush that you paint with here. Fifty states in one country, and another 60M people in the UK across its four countries. This feels like classic HN overreach.

Speaking only about US public schools, as long as your community is mostly middle class or above, your schools will be fine, as most funding comes from local property taxes. Note: This is different than almost all other highly developed nations that fund education from state or national level.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#92

Post by genewitch »

Insanity wrote: post #46

I had Covid once - when people considered the pandemic mostly “over” (early this year). The worst was the brain fog which took weeks to clear up.

i've never had covid, and i am unaware if this is in the literature because it may not be directly caused by the virus; but, did you have a lot of trouble sleeping/staying asleep? Anyone can reply, especially interested if you have a fitness band/watch that tracks sleep and breathing/heartrate, if you noticed that your sleep was greatly disrupted by the disease.

I had some weird virus a couple weeks ago that didn't seem like it could possibly be contagious, there was no outward symptoms like coughing or whatever. But one of the symptoms was the inability to sleep. I think i got my personal best "without sleep without any chemicals" - i wasn't eating much because i wasn't hungry - like at all, so no caffeine or sugar, no medications that would cause sleeplessness. I was up very nearly 43 hours. And i had to force myself to go to sleep, because i knew the auditory hallucinations were going to start soon - i get em, they're more annoying than tinnitus, at around the 45-48 hour mark, and they get progressively worse. Prior to being awake 42 hours, i had maybe 4 hours of sleep total, and leading up to that i had been up over 20 hours - so my sleep was completely ruined.

Due to the lack of sleep, i cannot remember anything that happened that week, or the week prior. Nor what i read (i read two books), who i talked to or about what. It's just blank - not fuzzy, not hard to recall, just nothing there.

How do i remember any details? i was live-posting about how poorly i felt and why, went back and read them, committed my posts to memory.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#93

Post by lmpdev »

School-Cotton wrote: post #12
dyauspitr wrote: post #7

Earlier quoted context omitted.

[flagged]

Not really clickbait. University of Kentucky press releases always refer to it as UK.

The original title isn’t clickbait in its context

It is a poorly written HN title though and should be changed

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#95

Post by shandor »

arcticbull wrote: post #32
_silicon wrote: post #31

Earlier quoted context omitted.

This is only partly true. There are many different factors increasing risk for Alzheimer’s which include environmental triggers that cause inflammation which can include but are not limited to viruses, bacteria, aging, arthritis, surgery, injury, etc

It's quite possible that it's environmental suppression of immunity, aging and/or degradation of the blood brain barrier that permits the viruses to make their way topside. There's some evidence that the amyloid plaques actually exhibit antimicrobial activity and may be an immune response to infection. [1] In my unsubstantiated opinion it's likely to be herpesviridae that make their way to the brain due to their affi…

> It also explains why acyclovir and valacyclovir dramatically reduces the risk of developing dementia.

Sounds fascinating, where could one read more about this? I don’t think I’ve come across this before.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#96

Post by H8crilA »

ME/CFS is seriously underinvested. I don't really understand why, any drug that makes a noticeable difference here will be a guaranteed money printer. There are millions of people suffering total disability, many in developed countries that have well funded medical insurance. Compare that to depression (which it only superficially resembles): many SSRIs, SNRIs, multiple "schools" of psychotherapy, neuroleptics, lithium, ketamine, ECT, ...

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#97

Post by andbberger »

H8crilA wrote: post #96

ME/CFS is seriously underinvested. I don't really understand why, any drug that makes a noticeable difference here will be a guaranteed money printer. There are millions of people suffering total disability, many in developed countries that have well funded medical insurance. Compare that to depression (which it only superficially resembles): many SSRIs, SNRIs, multiple "schools" of psychotherapy, neuroleptics, lithi…

it's stigmatized, has an overwhelmingly complex etiology and no clear empirical signature. i think for the most part people just don't think it's real

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#98

Post by mdp2021 »

xyst wrote: post #35
ljm wrote: post #22

Earlier quoted context omitted.

On the plus side, we don’t need to worry about spending our lives in an iron lung, smallpox is a non-issue, and in most of the west there isn’t much of a concern about a mother dying giving birth. Hot water can be taken for granted, as can indoor toilets. And central heating. With modern electronics and circuitry you can’t even kill yourself with a toaster in the bathtub since it will trip the central breaker. Every…

Except there’s a trend of slow reversal of the gains you speak of. Polio was diagnosed in an unvaccinated man in upstate NY (2022) [1] The anti vax movement and distrust of science has exploded since social media. > of the west there isn’t much of a concern about a mother dying giving birth. Depends on the state, or country. In the US, legality of abortion is left up to the states due to repeal of Roe v Wade by SCOTU…

> since social media

We must fix that construct: "«distrust [] has exploded since social media»". Which makes some sense, it is expectable in broad terms.

In 2021 a large wave of communication appropriated the banner of Science, through voices that had clearly never seen science in a postcard. (It probably varied with regional communication.) So, distrust spread.

What you are seeing is a crisis in authority - which also causes the first phenomenon of the rise of ignorant voices.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#99

Post by H8crilA »

andbberger wrote: post #97
H8crilA wrote: post #96

ME/CFS is seriously underinvested. I don't really understand why, any drug that makes a noticeable difference here will be a guaranteed money printer. There are millions of people suffering total disability, many in developed countries that have well funded medical insurance. Compare that to depression (which it only superficially resembles): many SSRIs, SNRIs, multiple "schools" of psychotherapy, neuroleptics, lithi…

it's stigmatized, has an overwhelmingly complex etiology and no clear empirical signature. i think for the most part people just don't think it's real

That's the thing: all of the above applies also to depression. And yet we do have quite a lot of options for treating it. Granted, they are not guaranteed to work, but they are sometimes/often effective, especially if you try a few of them in a sequence.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#100

Post by soulofmischief »

andbberger wrote: post #97
H8crilA wrote: post #96

ME/CFS is seriously underinvested. I don't really understand why, any drug that makes a noticeable difference here will be a guaranteed money printer. There are millions of people suffering total disability, many in developed countries that have well funded medical insurance. Compare that to depression (which it only superficially resembles): many SSRIs, SNRIs, multiple "schools" of psychotherapy, neuroleptics, lithi…

it's stigmatized, has an overwhelmingly complex etiology and no clear empirical signature. i think for the most part people just don't think it's real

After acquiring a bad case of mononucleosis at 18, I acquired CFS which lasted a number of years and severely impacted my ability to focus and make meaningful progress for extended periods of time, and this worsened my depression and anxiety, which exacerbated the problem in a positive feedback loop.

Everyone in my life disregarded me or didn't understand the severity of what I was dealing with. Looking back, returning to ADHD medicine back then might have been the best course of action, however a specialized treatment would be very welcome. Regardless of how others perceive the disease, people like me would greatly benefit.

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