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Researchers find Alzheimer's-like brain changes in long Covid patients

uknow.uky.edu

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Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#31

Alz is brain inflammatory response to viruses (among other foreing detritus) that got past the blood-brain barrier, so I'm not surprised.

This is only partly true. There are many different factors increasing risk for Alzheimer’s which include environmental triggers that cause inflammation which can include but are not limited to viruses, bacteria, aging, arthritis, surgery, injury, etc

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#32

Alz is brain inflammatory response to viruses (among other foreing detritus) that got past the blood-brain barrier, so I'm not surprised.

This is only partly true. There are many different factors increasing risk for Alzheimer’s which include environmental triggers that cause inflammation which can include but are not limited to viruses, bacteria, aging, arthritis, surgery, injury, etc

It's quite possible that it's environmental suppression of immunity, aging and/or degradation of the blood brain barrier that permits the viruses to make their way topside. There's some evidence that the amyloid plaques actually exhibit antimicrobial activity and may be an immune response to infection. [1]

In my unsubstantiated opinion it's likely to be herpesviridae that make their way to the brain due to their affinity for nerve tissue and the fact up to 80% of Americans have HSV1. Separately 50% of Americans have cytomegalovirus, another herpes virus. And yet more have HSV6 and HSV8. It's safe to assume over 90% of Americans have some latent herpes-family virus.

It also explains why acyclovir and valacyclovir dramatically reduces the risk of developing dementia.

[1] https://www.nature.com/articles/s41598-024-55423-9

[2] https://www.infectiousdiseaseadvisor.com/news/antivirals-for...

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#33
post #22

Earlier quoted context omitted.

On the plus side, we don’t need to worry about spending our lives in an iron lung, smallpox is a non-issue, and in most of the west there isn’t much of a concern about a mother dying giving birth. Hot water can be taken for granted, as can indoor toilets. And central heating. With modern electronics and circuitry you can’t even kill yourself with a toaster in the bathtub since it will trip the central breaker. Every…

All of this has been true for over half a century. The problem is that the direction of improvement in lives has changed. Compare today to the 90s and there’s very little reason to believe that today is better than the 90s in a developed country. What’s frustrating is that we have MORE tools to be in a much better shape right now. We have things available to us today that people wouldn’t have dreamt of in the 90s, in…

Safer and more reliable cars, cancer is less deadly, the HPV vaccine, malaria vsccines, lower homicide rate, I could go on but this seems like a good list.

Be careful where you get your data - news is biased towards sensationalism and negativity.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#34

Earlier quoted context omitted.

Why? Would this be more interesting if they were in the UK?

I feel like it would be trusted a little bit more if it was a study by the NHS from the UK rather than something from Kentucky.

I was just reading on the BBC that people were having to go overseas for critical surgeries because the NHS so woefully incompetent that people were on many years long waiting list. So maybe put "NHS excellence" on the shelf next to "Empire" as UK delusions that have long since passed.

U of Kentucky is a pretty decent school, ~25k students with (from personal experience) excellent Civil Engineering and Chemistry schools, at least.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#35
post #22
post #18

Today’s generations just do not get a break. Brain rot in the form of social media. Cognitive decline from possible long COVID. Constant exposure to microplastics from various sources (water contamination, water bottles, plastic wrapping, cars via tire breakdown). This timeline fucking sucks.

On the plus side, we don’t need to worry about spending our lives in an iron lung, smallpox is a non-issue, and in most of the west there isn’t much of a concern about a mother dying giving birth. Hot water can be taken for granted, as can indoor toilets. And central heating. With modern electronics and circuitry you can’t even kill yourself with a toaster in the bathtub since it will trip the central breaker. Every…

Except there’s a trend of slow reversal of the gains you speak of.

Polio was diagnosed in an unvaccinated man in upstate NY (2022) [1]

The anti vax movement and distrust of science has exploded since social media.

> of the west there isn’t much of a concern about a mother dying giving birth.

Depends on the state, or country. In the US, legality of abortion is left up to the states due to repeal of Roe v Wade by SCOTUS that’s hell bent on this Christian crusade.

Women have resorted to unsafe methods of abortion where traveling to an abortion clinic is not viable. In one case of a TX women, state courts refused to allow abortion to save mother [2]. She was fortunate to be able to travel to another state and get the medically required abortion.

[1] https://www.cnn.com/2022/07/21/health/new-york-polio/index.h...

[2] https://www.texastribune.org/2023/12/11/texas-abortion-lawsu...

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#36

Earlier quoted context omitted.

Not fully known but increasing evidence. Pretty stunning result is the discontinuity in all causes dementia for NHS seniors in Wales with the week of birth as the discontinuity point (week of birth is cutoff qualifier for a shingles vaccine)

The vaccine makes things better, I assume?

Correct. The study in question: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246135/

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#37

Earlier quoted context omitted.

It is not clear from your comment why always doing it would not be clickbait-like. I am sure even the majority of Americans would assume that when the letters “UK” are used in isolation, it would mean the country and not a state university.

Title should have been edited for posting here because the namespace scope is global. E.g. the local paper here has headlines like "MSU reserchers get grant" and everyone knows they're referring to Montana State University. But there's other MSUs, just two states away, so the same article carried by Reuters would need the headline changed.

See you say MSU and I assumed it was Mississippi State. So anything more than hyper local sources should probably spell it out completely.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#39
post #18

Today’s generations just do not get a break. Brain rot in the form of social media. Cognitive decline from possible long COVID. Constant exposure to microplastics from various sources (water contamination, water bottles, plastic wrapping, cars via tire breakdown). This timeline fucking sucks.

That view appears to discount just how horrible past generations had it. People living before around 1970 would have been in clover to have just those problems. Pick a decade in the past and it was generally pretty horrible.
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