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WTH Is Cerebrolysin, Actually?

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Re: WTH Is Cerebrolysin, Actually?

#41

Post by _nalply »

nradov wrote: post #34
_nalply wrote: post #20

Earlier quoted context omitted.

Perhaps. I wouldn't believe any statements that I learnt today before some research validating it, and even then only give a measure of confidency. Here I did that for you: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510857/ I trust NIH so my confidence that they write corresponds to truth is high even for the scientific interpretation of truth. And that's what they wrote: > Pigs were considered prion resistant as…

That article wasn't written by NIH staff. They just host a copy on their website which doesn't imply any endorsement or quality review.

Thanks for pointing that out. As one says, the devil is in the details. That's why I tend to use a scale for confidence.

Take this example of how I think: OP said, TIL that pigs are immune. This gave me misgivings.

I found a counter-proof from a government website I tend to trust, even if the material is not from them. So my confidence in the statement that pigs are immune went way down. In other words I am not sure that this statement isn't misinformation.

Re: WTH Is Cerebrolysin, Actually?

#44

Post by nwienert »

user_7832 wrote: post #19
nwienert wrote: post #10

Earlier quoted context omitted.

GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers…

What's slightly interesting to me is that some effects of adhd medications (particularly methylphenidate) sound quite similar - it too (can) change motivation regarding food (and actually can make unhealthy donuts seem disgusting) and of course suppresses apptetite (sometimes a little too much). I'd love to know if anyone who's taken both mph & a GLP-1 agonist how similar/different they are. (There's other interestin…

They are very, very different, almost not worth comparing.

Re: WTH Is Cerebrolysin, Actually?

#45

Post by nwienert »

marcinzm wrote: post #40
nwienert wrote: post #10

Earlier quoted context omitted.

GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers…

> I also think they are underrated Not sure if one can call a set of drugs that are so in demand as to be basically impossible to get at times underrated. Possibly random people online say otherwise but the market says the opposite very strongly.

Something can be highly rated and still under-rated, which is my claim. Almost no one knows about the effects beyond weight loss, and people who do often believe it's due to weight loss or fasting.

Re: WTH Is Cerebrolysin, Actually?

#46

Post by Loughla »

A_D_E_P_T wrote: post #17

"“nootropics” users be like: develop never-before-seen prion diseases from Belarusian nootropics made from centrifuged pig brains that you take intravenously but it was all worth it to accomplish great things like posting on an internet messageboard about nootropics" - The Mighty Hakan

I got into nootropics to help me sleep and try to learn how to lucid dream.

I got out of nootropics because anything that can make you lucid dream must have some kind of impact on your brain, and the ENTIRE culture of nootropics is based on being more productive at work (at least the forums I was on).

It was kind of gross, to be honest. Put these chemicals in your body so you can focus x% more at your job. No thank you.

Re: WTH Is Cerebrolysin, Actually?

#47

Post by im3w1l »

Loughla wrote: post #46
A_D_E_P_T wrote: post #17

"“nootropics” users be like: develop never-before-seen prion diseases from Belarusian nootropics made from centrifuged pig brains that you take intravenously but it was all worth it to accomplish great things like posting on an internet messageboard about nootropics" - The Mighty Hakan

I got into nootropics to help me sleep and try to learn how to lucid dream. I got out of nootropics because anything that can make you lucid dream must have some kind of impact on your brain, and the ENTIRE culture of nootropics is based on being more productive at work (at least the forums I was on). It was kind of gross, to be honest. Put these chemicals in your body so you can focus x% more at your job. No thank y…

To me your perspective comes from a narrow view of what a job is. Hours go in money comes out.

But it can be more than that. It can be a calling. A passion. A way to gain immortal glory by being named the discoverer of something. A way to create value and happiness for others.

Re: WTH Is Cerebrolysin, Actually?

#48

Post by joseluis »

Loughla wrote: post #46
A_D_E_P_T wrote: post #17

"“nootropics” users be like: develop never-before-seen prion diseases from Belarusian nootropics made from centrifuged pig brains that you take intravenously but it was all worth it to accomplish great things like posting on an internet messageboard about nootropics" - The Mighty Hakan

I got into nootropics to help me sleep and try to learn how to lucid dream. I got out of nootropics because anything that can make you lucid dream must have some kind of impact on your brain, and the ENTIRE culture of nootropics is based on being more productive at work (at least the forums I was on). It was kind of gross, to be honest. Put these chemicals in your body so you can focus x% more at your job. No thank y…

That's exactly how I see coffee, and I keep stopping taking it and then coming back every few months...

Re: WTH Is Cerebrolysin, Actually?

#49

Post by kalium-xyz »

In using cerebrolysin I've always assumed that if it is a placebo the rituals and concepts behind it make it a very good placebo. It has a lot of "medical" potency to it because the idea of injecting pig brain "just makes sense". Also I really enjoyed my vacation to eastern Europe to acquire a stash of it.

For its clinical validity I do recall that it passed some clinical trails which I'd need to look up again however like most studies with cerebrolysin it was done in shadier more bribe friendly corners of the globe so its easy to dismiss the positives. Like the study on ADHD in adults done in russia where it massively helped the participants but the sample size was very tiny. Also I highly doubt that it actually cured "mental retardation in children" like some of the packaging claims.

EDIT: here we go for the clinical trails: https://go.drugbank.com/drugs/DB16599

Re: WTH Is Cerebrolysin, Actually?

#50

Post by kalium-xyz »

gus_massa wrote: post #37
vasco wrote: post #24

Earlier quoted context omitted.

> It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Even if you are not very smart, doing some tests on yourself seems easy enough. If you pull up any psychology paper on like effecs of CO2 on cognition, and do the tests on yourself, you'd expect to start doing better after a few weeks of taking it, and if not stop.…

With most test, the problem is that after a few weeks you learn to solve them more efficiently [1] and the improvement can be falsely attributed to the nootropics. Double blind randomized controlled trial or it didn't happen. [1]In the math class, we call it "studding for the midterm" :)

the nootropics community suffers from certain individuals who will retake free online IQ test with only a few days in between to "test" these drugs. It doesn't really work well... For a proper retest one has to wait at least 6 months.
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