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WTH Is Cerebrolysin, Actually?

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Re: WTH Is Cerebrolysin, Actually?

#31

Post by Rebellos »

_nalply wrote: post #20
rdtsc wrote: post #2

> Pigs were a fortuitous choice due to the fact that they are especially resistant to prion disease Prions is the first thing that came to mind after reading the description. I had not idea pigs are resistant to it. TIL.

Perhaps. I wouldn't believe any statements that I learnt today before some research validating it, and even then only give a measure of confidency. Here I did that for you: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510857/ I trust NIH so my confidence that they write corresponds to truth is high even for the scientific interpretation of truth. And that's what they wrote: > Pigs were considered prion resistant as…

Great paper! Sorry to nitpick, because your approach is right, but one important detail is wrong - you are not reading what NIH said, but simply a paper made by someone that NIH provides access to. It is important to remember that things on pubmed can be wrong, or subjective and biased.

See header "As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.", and you can click on "Author information" to learn more about the authors.

Re: WTH Is Cerebrolysin, Actually?

#32

Post by ipsum2 »

emsign wrote: post #15

> Ever Pharma’s explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Anyway this looks like your typi…

Even TCM is more scientifically backed than Cerebrolysin. See the research on cordyceps for example.

https://www.nature.com/articles/s41598-024-58742-z

https://en.wikipedia.org/wiki/Cordyceps_militaris#Research

Re: WTH Is Cerebrolysin, Actually?

#33

Post by darwinaward »

vasco wrote: post #24
emsign wrote: post #15

> Ever Pharma’s explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Anyway this looks like your typi…

> It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Even if you are not very smart, doing some tests on yourself seems easy enough. If you pull up any psychology paper on like effecs of CO2 on cognition, and do the tests on yourself, you'd expect to start doing better after a few weeks of taking it, and if not stop.…

Taking untested drugs is risky because self-testing is unreliable, can lead to serious health problems, and lacks the expert guidance needed to safely assess their effects. Anyone who does this deserves the Darwin award and science CATEGORICALLY advises you to do something else. Those who find medical breakthroughs did not take shortcuts. They are trained and experienced and painstaking.

Do something well tested and proven to work instead and reap the benefits of all of these proven trained professionals. One idea: Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans.

Re: WTH Is Cerebrolysin, Actually?

#34

Post by nradov »

_nalply wrote: post #20
rdtsc wrote: post #2

> Pigs were a fortuitous choice due to the fact that they are especially resistant to prion disease Prions is the first thing that came to mind after reading the description. I had not idea pigs are resistant to it. TIL.

Perhaps. I wouldn't believe any statements that I learnt today before some research validating it, and even then only give a measure of confidency. Here I did that for you: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510857/ I trust NIH so my confidence that they write corresponds to truth is high even for the scientific interpretation of truth. And that's what they wrote: > Pigs were considered prion resistant as…

That article wasn't written by NIH staff. They just host a copy on their website which doesn't imply any endorsement or quality review.

Re: WTH Is Cerebrolysin, Actually?

#35

Post by vasco »

darwinaward wrote: post #33
vasco wrote: post #24

Earlier quoted context omitted.

> It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Even if you are not very smart, doing some tests on yourself seems easy enough. If you pull up any psychology paper on like effecs of CO2 on cognition, and do the tests on yourself, you'd expect to start doing better after a few weeks of taking it, and if not stop.…

Taking untested drugs is risky because self-testing is unreliable, can lead to serious health problems, and lacks the expert guidance needed to safely assess their effects. Anyone who does this deserves the Darwin award and science CATEGORICALLY advises you to do something else. Those who find medical breakthroughs did not take shortcuts. They are trained and experienced and painstaking. Do something well tested and…

I don't take any of this, I think they are just bait for people that want to "be better" without doing work. But what I mean is know many people that do take nootropics or "microdose" mushrooms or whatever and they never test their own cognitive abilities in a standard way before and after they start. It's almost like they don't care if it works.

Re: WTH Is Cerebrolysin, Actually?

#36

Post by oezi »

knodi123 wrote: post #4

Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??

Your question should be split into two parts:

- Miracle drugs for curing ailments. We have plenty of those.

- Miracle drugs for enhancing beyond normal. Many things which work also have serious side-effects. Most things which are peddled with prescription don't have any effect.

Re: WTH Is Cerebrolysin, Actually?

#37

Post by gus_massa »

vasco wrote: post #24
emsign wrote: post #15

> Ever Pharma’s explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Anyway this looks like your typi…

> It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Even if you are not very smart, doing some tests on yourself seems easy enough. If you pull up any psychology paper on like effecs of CO2 on cognition, and do the tests on yourself, you'd expect to start doing better after a few weeks of taking it, and if not stop.…

With most test, the problem is that after a few weeks you learn to solve them more efficiently [1] and the improvement can be falsely attributed to the nootropics. Double blind randomized controlled trial or it didn't happen.

[1]In the math class, we call it "studding for the midterm" :)

Re: WTH Is Cerebrolysin, Actually?

#38

Post by duskwuff »

ipsum2 wrote: post #32
emsign wrote: post #15

> Ever Pharma’s explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Anyway this looks like your typi…

Even TCM is more scientifically backed than Cerebrolysin. See the research on cordyceps for example. https://www.nature.com/articles/s41598-024-58742-z https://en.wikipedia.org/wiki/Cordyceps_militaris#Research

Or artemisinin, which was discovered by Chinese researchers reviewing TCM texts discussing treatments for malaria. (The lead researcher, Tu Youyou, received a Nobel Prize for her work in 2015.)

Re: WTH Is Cerebrolysin, Actually?

#39

Post by dillydogg »

thomasfedb wrote: post #13
knodi123 wrote: post #4

Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??

Paracetamol (acetaminophen) - a fairly effective, synergistic, non-addictive, predictably dosed, analgesic.

I've been told by a number of my attending physicians that it is unlikely that acetaminophen would have received FDA approval if it was being reviewed today because of it' small therapeutic window and unknown mechanism of action

Re: WTH Is Cerebrolysin, Actually?

#40

Post by marcinzm »

nwienert wrote: post #10
knodi123 wrote: post #4

Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??

GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers…

> I also think they are underrated

Not sure if one can call a set of drugs that are so in demand as to be basically impossible to get at times underrated. Possibly random people online say otherwise but the market says the opposite very strongly.

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