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Jake Seliger has died

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Re: Jake Seliger has died

#211

Post by ETH_start »

llamaimperative wrote: post #201
ETH_start wrote: post #199

Earlier quoted context omitted.

Experimental drugs cannot be given freely like supplements.

Of course they can. You take any molecule, put it in a pill bottle, disclose there's no clinical evidence of its efficacy and you can put it on store shelves. There are thousands of such products on the market today. Stores will often put these in a section called "Supplements" so that people don't mistake them for medications which have proven their efficacy. These molecules generally don't do anything of substantia…

If the manufacturer creates the substance with the intention of treating a disease, then the substance falls under FDA restrictions, irrespective of whether they make explicit claims about its medical benefits.

Re: Jake Seliger has died

#212

Post by JamesSwift »

Fire-Dragon-DoL wrote: post #168
JamesSwift wrote: post #63

Earlier quoted context omitted.

I think thats why cancer is such a vicious illness to have a loved one experience. Its a long drawn-out suffering, with an inevitability at the end of it. The body shuts down gradually as the cancer wins out. For my sister it was the same with 'good days' vs 'bad days'. At first bad days were the minority and over time the ratio changed.

A sister's friend's mother had a very aggressive cancer that was diagnosed and in 10 days killed her. In a twisted way, I think that might be worse than tge long drawn battle, where more time is available. I have no first hand experience, so this is speculation. It was just shocking to hear.

Yeah its two sides of the same coin. In some ways its easier, in some ways its harder. They both suck in their own ways.

Re: Jake Seliger has died

#213

Post by adaml_623 »

akavi wrote: post #100
adaml_623 wrote: post #96

Earlier quoted context omitted.

I agree with you in spirit but would suggest that pushing for more funding of schools, universities, basic research, and applied research is something that we should all be doing. Imagine if all the smart people tried to cure cancer instead of working in Wall Street and Adtech

That's going to be hard to do so long as we continue regarding someone who makes a billion from a new cancer drug as as a price-gouging murderer while regarding someone who makes a billion from starting an adtech company with mere indifference.

Very valid point. We do have Nobel prizes but they are an exception to an otherwise problematic set of incentives

Re: Jake Seliger has died

#214

Post by viccis »

umvi wrote: post #94

I'm sort of afraid to ask since everyone seems to know, but... what is he known for? Usually black bar means a tech giant has died, but absent a wiki page I'm having a hard time finding anything on google about him except the news of his death...

I had the same question and it mostly looks like rationalist/libertarian space posting like you saw a lot of on the internet in the 2000s in particular. His wife seems to be active in similar areas (went on a far right think tank podcast run by one of the 2010s alt-right crowd guys last month to talk about deregulating the FDA) so I'd imagine if you are of that bent, they're known pretty well.

RIP

Re: Jake Seliger has died

#215

Post by dang »

vinnyvichy wrote: post #174
_yb2s wrote: post #77

Earlier quoted context omitted.

As someone that works in drug discovery as an academic and has patented drugs, I can tell you that the current process is biased way too far towards safety for optimal life saving outcomes if you look at it in a cold utilitarian way. A lot of lives would be saved by fast-tracking the approval process, despite the fact that there would also be an increase in negative outcomes. However, it is probably not socially or p…

[flagged]

Your account has unfortunately been inundating HN threads with repetitive, off-topic, and/or meta posting.

Since we asked you to stop and you just did another entire thwack of it, I've banned the account.

Please don't create accounts to break HN's rules with. It will eventually get your main account banned as well.

Re: Jake Seliger has died

#217

Post by fatnoah »

llamaimperative wrote: post #49
fatnoah wrote: post #20

Earlier quoted context omitted.

I've experienced this from both sides. First with my father who was dying of cancer and was informed that while some promising treatments were in trials, he was not eligible. Balancing potential harm from unapproved drugs vs. certain death within 12 months feels like an easy task. On the other side, my wife worked for a mid-sized pharma in the past. After several rounds of trials that each cost tens of millions of do…

Part of the harm is in people no longer trusting drugs. We're very fortunate to be able to get prescribed a drug and have certainty the risk-reward tradeoffs have been evaluated to extreme depth by experts far more equipped than we are.

> Part of the harm is in people no longer trusting drugs.

I'm not sure how trust would be eroded by the failure of an experimental drug to treat a terminal case where no other drugs are working.

Re: Jake Seliger has died

#218

Post by fatnoah »

newzisforsukas wrote: post #36
fatnoah wrote: post #20

Earlier quoted context omitted.

I've experienced this from both sides. First with my father who was dying of cancer and was informed that while some promising treatments were in trials, he was not eligible. Balancing potential harm from unapproved drugs vs. certain death within 12 months feels like an easy task. On the other side, my wife worked for a mid-sized pharma in the past. After several rounds of trials that each cost tens of millions of do…

What was the drug?

TBH, I don't remember the name as it was one of those crazy generic beezelebubatab type of generic names.
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