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Jake Seliger has died

marginalrevolution.com

201–210 of 220 posts

Re: Jake Seliger has died

#201

Earlier quoted context omitted.

You mean like supplements, which exist today?

Experimental drugs cannot be given freely like supplements.

Of course they can. You take any molecule, put it in a pill bottle, disclose there's no clinical evidence of its efficacy and you can put it on store shelves. There are thousands of such products on the market today. Stores will often put these in a section called "Supplements" so that people don't mistake them for medications which have proven their efficacy.

These molecules generally don't do anything of substantial value because it's incredibly difficult and expensive to produce a molecule that does anything of value. If you're going to undertake that billion dollar effort, then you're going to want consumers to trust it, pharmacies to carry it (near the medications, not the unproven supplements), and most critically: insurers to pay for it.

You do not have to seek FDA clearance to sell your molecule to consumers. To achieve marketing objectives necessary to recoup the development costs of a working molecule, you choose to seek FDA clearance.

What exactly do you think distinguishes an "experimental drug" that's not going to be put through trials from the thousands of other unproven molecules typically sold on aisles labeled "Supplements" or behind the counter at gas stations? Your hope, belief, or presumption that it actually works?

Re: Jake Seliger has died

#202
post #77

Earlier quoted context omitted.

As someone that works in drug discovery as an academic and has patented drugs, I can tell you that the current process is biased way too far towards safety for optimal life saving outcomes if you look at it in a cold utilitarian way. A lot of lives would be saved by fast-tracking the approval process, despite the fact that there would also be an increase in negative outcomes. However, it is probably not socially or p…

[flagged]

I also love that quote "science is the belief in the ignorance of experts" - I wish that concept were more clear to people that are lay people interested in science, but end up practicing scientism in a way that discourages actual scientific thinking.

I am not going to share my work on here- I wish to remain anonymous on here, but am also outspoken about this topic in my public professional persona.

Re: Jake Seliger has died

#203

Jake posted as jseliger on HN: https://news.ycombinator.com/user?id=jseliger He blogged at https://jakeseliger.com/ >, and numerous of his blog articles were submitted to HN: https://news.ycombinator.com/from?site=jakeseliger.com >. That includes numerous topics, over the past year or so his experience with cancer, often concerning frustrations with the process and mechanism. His essay on agenticness especially strik…

How old was he ?

Far too young.

Re: Jake Seliger has died

#205
post #159

Hi everyone, This is Bess, Jake's wife. I just want to say how deeply touched I am to see how much Jake and his writing are appreciated here on HN. The intellectual online community which made up a big piece of his life for so long was important to him, as was having a positive influence on others, and it would have meant so much to him- as it does to me- to see the impact he made. Thank you for the people who reache…

Condolences to you and your family. I wish you great success in your journey in making clinical trials more available.

Re: Jake Seliger has died

#206
post #179
post #129

Earlier quoted context omitted.

You and the GGP author joined in 2018, so maybe you haven't noticed yet, but the black bar has always very much been an "at the whims of the site operator" thing. If you try to apply any other metric (like "tech giant"), you'll be scratching your head at who gets one and who gets left out. (I don't think you're missing anything, the only thing I know about this person is that according to my browser history I visited…

> You and the GGP author joined in 2018, so maybe you haven't noticed yet, but the black bar has always very much been an "at the whims of the site operator" thing. I'm not questioning that at all . I'm just trying to understand who this person was and why they're getting this attention.

Because he was a part of the community. Simple as that. People appreciated him, and now remember him fondly. A mark of respect, perhaps.

Re: Jake Seliger has died

#207
post #202

Earlier quoted context omitted.

[flagged]

I also love that quote "science is the belief in the ignorance of experts" - I wish that concept were more clear to people that are lay people interested in science, but end up practicing scientism in a way that discourages actual scientific thinking. I am not going to share my work on here- I wish to remain anonymous on here, but am also outspoken about this topic in my public professional persona.

Understood.

Re: Jake Seliger has died

#208
post #159

Hi everyone, This is Bess, Jake's wife. I just want to say how deeply touched I am to see how much Jake and his writing are appreciated here on HN. The intellectual online community which made up a big piece of his life for so long was important to him, as was having a positive influence on others, and it would have meant so much to him- as it does to me- to see the impact he made. Thank you for the people who reache…

Love you Bess <3

Re: Jake Seliger has died

#209

Jake posted as jseliger on HN: https://news.ycombinator.com/user?id=jseliger He blogged at https://jakeseliger.com/ >, and numerous of his blog articles were submitted to HN: https://news.ycombinator.com/from?site=jakeseliger.com >. That includes numerous topics, over the past year or so his experience with cancer, often concerning frustrations with the process and mechanism. His essay on agenticness especially strik…

How old was he ?

Only 40
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