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Robin Warren, pathologist who rewrote the science on ulcers, has died

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Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#61

Earlier quoted context omitted.

Thats a bit of a myth though. Stress is still known to be a factor in causing ulcers. https://www.ingentaconnect.com/content/ben/cpd/2020/00000026...

I had gastritis (duodenitis, in fact) a couple of years back, and the first thing they did was test me for H. pylori. I didn't have it. Doctor told me a vast majority of people with such issues do. After a gastroscopy, they concluded that it was just stress and nothing else, but inflamation wouldn't heal on its own, so I got pantoprazole (PPI) and stopped ingesting potentially irritating food (caffeine, alcohol, spic…

Wow, carbonated water is not good overall.

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#62
post #53
post #52

Earlier quoted context omitted.

Sounds like they are still trying to use lanasterol: https://pubmed.ncbi.nlm.nih.gov/36484206/ I see stories about this being used for cataracts going back almost a decade. Medicine advances so slowly.

Of course, as lanosterol is how your body does it when things work ok on their own. The issue is delivery, and for unknown reason they are doing it without DMSO or anything similar. Lanosterol with its large molecular weight have no chances of making it inside on its own. The other way of course is injecting it directly into the eye, and it probably would have to be done many times, and, once injections stop, the cry…

the bigger problem is that if society collapses again there are few easily-accessible resources anymore, particularly fuel/energy. Consider the coincidence of factors that led to the industrial age in Britain… some of those can’t be reproduced again.

Mining garbage dumps for resources could of course be a thing, but probably not abundant energy.

This time there is no plan B. We either become an interplanetary species or this planet eventually becomes our tomb. Probably a couple millennia.

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#63
post #62
post #53

Earlier quoted context omitted.

Of course, as lanosterol is how your body does it when things work ok on their own. The issue is delivery, and for unknown reason they are doing it without DMSO or anything similar. Lanosterol with its large molecular weight have no chances of making it inside on its own. The other way of course is injecting it directly into the eye, and it probably would have to be done many times, and, once injections stop, the cry…

the bigger problem is that if society collapses again there are few easily-accessible resources anymore, particularly fuel/energy. Consider the coincidence of factors that led to the industrial age in Britain… some of those can’t be reproduced again. Mining garbage dumps for resources could of course be a thing, but probably not abundant energy. This time there is no plan B. We either become an interplanetary species…

They'd mine ruins of the fallen civilization, not dumps.

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#64
post #41

Related: https://news.ycombinator.com/item?id=41118638

I've moved those comments hither. Thanks!

Please accept this comment as my perpetual permission to edit or remove my stub comments in this regards, and replace them with your own references.

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#65
post #7

Earlier quoted context omitted.

Can help to fix the: "this is caused by stress", when actually you needed antibiotics that already exists and were known at the time :|

Thats a bit of a myth though. Stress is still known to be a factor in causing ulcers. https://www.ingentaconnect.com/content/ben/cpd/2020/00000026...

what stress exactly? will a bad breakup cause ulcers? will hitting the gym cause ulcers?

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#66
post #65

Earlier quoted context omitted.

Thats a bit of a myth though. Stress is still known to be a factor in causing ulcers. https://www.ingentaconnect.com/content/ben/cpd/2020/00000026...

what stress exactly? will a bad breakup cause ulcers? will hitting the gym cause ulcers?

Burns and other life threatening conditions are the main cause. Between 60 and 100% of patients entering the ICU have stress ulcers. Chronic workplace stress, job frustration and family problems are also associated with ulcer development.

https://www.ingentaconnect.com/content/ben/cmm/2008/00000008...

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#67
post #62
post #53

Earlier quoted context omitted.

Of course, as lanosterol is how your body does it when things work ok on their own. The issue is delivery, and for unknown reason they are doing it without DMSO or anything similar. Lanosterol with its large molecular weight have no chances of making it inside on its own. The other way of course is injecting it directly into the eye, and it probably would have to be done many times, and, once injections stop, the cry…

the bigger problem is that if society collapses again there are few easily-accessible resources anymore, particularly fuel/energy. Consider the coincidence of factors that led to the industrial age in Britain… some of those can’t be reproduced again. Mining garbage dumps for resources could of course be a thing, but probably not abundant energy. This time there is no plan B. We either become an interplanetary species…

well, may be civilization would be much better off if we went straight to electrified industrial society using wind and hydro energy bypassing burning of dinosauruses - windmills and watermills were known for millennia, one only had to add copper winding and some magnetic iron, the things available for the last 2000+ years.

> We either become an interplanetary species or this planet eventually becomes our tomb.

Yes, only my version of the "tomb" is that it would be our planetary scale ant city/colony as we become totally connected and our societies naturally become highly totalitarian (not necessarily due to some ideology, you'd just naturally have less and less space/resources/opportunities for your private endeavors). Some ant colonies exist uninterrupted for several thousand years, no progress, just happy busy ants doing their happy stuff. Only few of us who'd get off that planet will have a chance to continue the civilizational progress. Kind of bifurcation of our species. Interesting that Musk advances our civilization in both directions - neural implants as well as SpaceX.

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#68
post #61

Earlier quoted context omitted.

I had gastritis (duodenitis, in fact) a couple of years back, and the first thing they did was test me for H. pylori. I didn't have it. Doctor told me a vast majority of people with such issues do. After a gastroscopy, they concluded that it was just stress and nothing else, but inflamation wouldn't heal on its own, so I got pantoprazole (PPI) and stopped ingesting potentially irritating food (caffeine, alcohol, spic…

Wow, carbonated water is not good overall.

Yeah, and I didn't drink too much of it either; like 1 or 2 glasses a day, often 0, probably 1 on average.

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#69
post #20
post #13

I got an ulcer about ten years ago, well after Warren's research, I went to a doctor and he told me that the ulcer was caused by stress. I said something like "didn't someone get a Nobel prize proving that ulcers were bacterial?" and the doctor hadn't heard that and "prescribed" me to get more rest and try and be less concerned about work. I got a different doctor after that. Robin Warren is someone who I respected t…

The handful of times I've had ulcers in the past it was certainly correlated with stress. Perhaps indirectly through some other effects, but stress feels like part of the equation IME, at least for some people.

You likely have chronic heliobacter pylori infection and should really look into that. It’s a silent killer and that way beyond just ulcers since it’s a potent acetaldehyde producing microbe. Tests are often false negative because they can hide in places, eg Candida vacuoles: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101746/

Re: Robin Warren, pathologist who rewrote the science on ulcers, has died

#70
post #57

Earlier quoted context omitted.

Science advances one funeral at a time

More specifically Max Planck wrote: "A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die and a new generation grows up that is familiar with it ..." https://en.wikipedia.org/wiki/Planck%27s_principle

Most famously quoted in the Structure of Scientific Revolutions, which seems apt to link here: https://en.wikipedia.org/wiki/The_Structure_of_Scientific_Re...
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