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Scientists discover a cause of lupus, possible way to reverse it

news.feinberg.northwestern.edu

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Re: Scientists discover a cause of lupus, possible way to reverse it

#161

Post by tuennesje »

theferalrobot wrote: post #92
notheyarent wrote: post #86

they aren’t cell diseases. It is plant toxins either leaking into the blood stream through intestinal permeability or a problem with peoples livers being fatty and not able to do their job anymore resulting in the bodies inability to remove plant toxins. The toxins cause an immune reaction wherever they build up , rheumatoid arthritis if it’s the joints of the legs and arms etc. Plant toxins include pesticides, fungi…

Wouldn't then the cure just be to eat organic food, rather than meat of animals that were fed way worse crap than the average person? The whole premise makes no sense...

I believe no one diet works equally for every single individual with Autoimmune conditions. For some, a plant-based diet reduces symptoms, for others like Jordan B. Peterson, and his daughter (I believe she suffered from RA) a purely meat-based diet reduced all of their symptoms. Personally, I struggle with Hashimotos, Ankylosing Spondylitis and Crohn's Disease and have to stay away from sugary foods, alcohol and caffeine or else one of the conditions will flare up. Any type of meat is fine for me however.

Re: Scientists discover a cause of lupus, possible way to reverse it

#162

Post by tremon »

COGlory wrote: post #135
aroopchandra wrote: post #126

I was diagnosed with lupus a few years ago. My mom also had it and passed away after 10 years due to complications. My initial symptoms were severe joint pains, which made daily activities difficult. This happened during the COVID lockdown, which helped me maintain my job. I did a lot of research and tried various treatments. Functional medicines and expensive vitamins didn’t help. I read about long-term fasting and…

I'm curious if you've looked into N-Glycolylneuraminic acid and whether that could be the issue? Does chicken cause an issue for you? I'm sorry to hear about your Lupus diagnosis, and glad it's in remission. My doctor wanted to diagnose me with Lupus due to the facial rash and arthritis/joint pain, but I came back negative in all the bloodwork, which I think means about 98% sure don't have it. I found that I can trea…

I came back negative in all the bloodwork

One of my friends has APLS (antiphospholipid antibody syndrome), which can also occur as a secondary symptom of Lupus. All of her blood tests always come back negative due to the way APLS affects coagulation -- unless the bloodwork is cultured for at least two days. So if you have reason to suspect the test results may be incorrect, ask them to re-do the bloodwork as a long-term culture rather than the normal fast screening.

Re: Scientists discover a cause of lupus, possible way to reverse it

#163

Post by aroopchandra »

bumby wrote: post #154
aroopchandra wrote: post #149

Earlier quoted context omitted.

I eat a lot of legumes such as lentils, chickpeas, black beans, and peas. I also include tofu made from soy, and nuts like almonds, peanuts, as well as seeds like chia, flaxseeds, and hemp. I use plant-based protein powders too specifically ( https://lovecomplement.com/products/complement-organic-vegan... ) when I drink green smoothies (3 to 4 meals a week). Green leafy vegetables also has a lot protein (Kale, Brocco…

> I use supplements for B12 which is missing from vegetable foods. Just in case you're looking for an inexpensive vegan whole food source, seaweed sheets (like those used in sushi) have a relatively high amount of B12. I took a look at the brand in my pantry and it has 60% RDA per sheet.

Thats a good idea. I will for sure add it to my snacks as I actually like seaweed

Re: Scientists discover a cause of lupus, possible way to reverse it

#164

Post by aroopchandra »

schlick wrote: post #155
aroopchandra wrote: post #149

Earlier quoted context omitted.

I eat a lot of legumes such as lentils, chickpeas, black beans, and peas. I also include tofu made from soy, and nuts like almonds, peanuts, as well as seeds like chia, flaxseeds, and hemp. I use plant-based protein powders too specifically ( https://lovecomplement.com/products/complement-organic-vegan... ) when I drink green smoothies (3 to 4 meals a week). Green leafy vegetables also has a lot protein (Kale, Brocco…

Maybe a crazy take here but it sounds like the Lupus actually made you healthier? Either way congrats on finding a way towards living a happy and healthy life, props to you.

For sure it did make me healthier and know my body better

Re: Scientists discover a cause of lupus, possible way to reverse it

#165

Post by aroopchandra »

xdrone wrote: post #157
aroopchandra wrote: post #126

I was diagnosed with lupus a few years ago. My mom also had it and passed away after 10 years due to complications. My initial symptoms were severe joint pains, which made daily activities difficult. This happened during the COVID lockdown, which helped me maintain my job. I did a lot of research and tried various treatments. Functional medicines and expensive vitamins didn’t help. I read about long-term fasting and…

In the vegan community there is lost of discussion of animal products causing auto immune issues. A compromised gut lining will let intact animal proteins into the body. The immune sees the animal foreigners but also attacks our body; us being animals too. Type 1 diabetes, aka childhood diabetes, is thought to be from casein in A1 milk; where the immune system attacks the beta cells of the pancreas. Seems plausible t…

I also read this in multiple places and trusted it. At least that's how I internalized my condition when I started the experiment.

Re: Scientists discover a cause of lupus, possible way to reverse it

#166

Post by ck2 »

ta988 wrote: post #120
ck2 wrote: post #116

Earlier quoted context omitted.

try LibSTC

It says "Sorry, the file is absent :("

I am sure it will be there eventually.

This is a preprint of the abstract to the paper and I know there are some very smart people on HN but if you can grasp this you are in an entirely much higher orbit

https://acrabstracts.org/abstract/cxcl13-t-cell-differentiat...

What's interesting is that AHR is also involved in Covid infections so this will highly likely be further researched.

Re: Scientists discover a cause of lupus, possible way to reverse it

#167

Post by valgor »

xdrone wrote: post #157
aroopchandra wrote: post #126

I was diagnosed with lupus a few years ago. My mom also had it and passed away after 10 years due to complications. My initial symptoms were severe joint pains, which made daily activities difficult. This happened during the COVID lockdown, which helped me maintain my job. I did a lot of research and tried various treatments. Functional medicines and expensive vitamins didn’t help. I read about long-term fasting and…

In the vegan community there is lost of discussion of animal products causing auto immune issues. A compromised gut lining will let intact animal proteins into the body. The immune sees the animal foreigners but also attacks our body; us being animals too. Type 1 diabetes, aka childhood diabetes, is thought to be from casein in A1 milk; where the immune system attacks the beta cells of the pancreas. Seems plausible t…

Funny enough, I mentioned not eating meat on another hackernews thread today and someone told me I'm going to get an autoimmune disease.

Re: Scientists discover a cause of lupus, possible way to reverse it

#169

Post by lhoff »

aroopchandra wrote: post #134
wholinator2 wrote: post #133

Earlier quoted context omitted.

I have crohn's disease which is also autoimmune and directly related to ingesting certain things. I think a lot of autoimmunity has to do with intestinal bacteria and their relationship to our innate immune system. And to a lesser extent it seems that almost every aspect of life is effected by what we eat, how we feel, how we act, how we grow and die. Maybe in 100 years we'll have fecal tests and bacteria pills to ca…

I got fecal tests and used expensive supplements and vitamins as recommended by a functional doctor, but they didn't help. I looked into how immune suppression medicines like Benlysta work and tried to mimic their effects naturally to get relief and hopefully stop using medicine. I think food can help manage many side effects of immune-related diseases, even if it can't cure them.

You might want to try the Wim Hof Method. I don't believe in everthing Wim Hof attributes to his method but when it comes to immune response, there is scientific evidence that it does indeed result in an increase of IL-10, which is anti inflammatory.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034215/

Re: Scientists discover a cause of lupus, possible way to reverse it

#170

Post by atombender »

dg08 wrote: post #91
atombender wrote: post #8

Earlier quoted context omitted.

The aryl hydrocarbon receptor (AhR), which is key to this discovery, appears to be super relevant to psoriasis, another autoimmune disease. AhR has been known for a long time, but it seems it's been somewhat mysterious until a series of recent breakthroughs. In 2022, an AhR inhibitor called tapinarof, sold as VTAMA, was launched, and has shown itself to be one of the most effective treatments for psoriasis to date. I…

Thanks for posting this. My doc just prescribed vtama for me a month ago and my psoriasis was gone in less than a week. I didn’t even finish the sample tube he gave me. Far more effective than the steroid topical cream I was using before. I had no idea what vtama was until reading your post.

Yep. The nice thing about VTAMA is that it can be used continuously, unlike steroid creams. And it's unique among current topical meds in that it can provide sustained remission.

It may be that VTAMA reduces TRM cells in the skin, which are the T-cells responsible for relapse. There's is an ongoing clinical trial right now called KNOCKOUT [1] that gives patients a "megadose" of Skyrizi, an IL-23 inhibitor that has, like VTAMA, been shown to reduce TRM cells. The idea is that a single huge dose could effectively cure psoriasis, or at least suppress it for a very long time. The results so far show that 83% of patients achieved complete clearance after six months, which was sustained throughout the trial period. I'm confident it will be a game changer. Here [2] is an interview with the main researcher.

Among new psoriasis drugs, there is also Zoryve, a PDE4 inhibitor (same mechanism as Otezla) as a cream or foam, which has a different mechanism of action.

[1] https://www.hcplive.com/view/risankizumab-dose-clears-psoria...

[2] https://www.hcplive.com/view/rizankizumab-knockout-study-and...

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