HTMX is like a glimpse into the road not taken, where HTML is the main language of the web instead of JS. Sometimes the grass really is greener on the other side, and I hope as an industry we make the switch.
This is a good essay on the topic: https://htmx.org/essays/when-to-use-hypermedia/
Definitely one place htmx can be abused is oob-swap: https://htmx.org/attributes/hx-swap-oob/, which allows any given HTMX request to replace any part of the page. It sort of destroys the concept of locality of concern that HTMX pushes for.