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Story of Vitamin D Toxicity (2022)

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Re: Story of Vitamin D Toxicity (2022)

#161

Post by ndsipa_pomu »

atombender wrote: post #160
ndsipa_pomu wrote: post #157

Earlier quoted context omitted.

One of the problems with psoriasis is that it seems to behave differently for different people and also changes over time too which makes it very much a case of trial and error to find what treatments work for people. There's definitely a link between psoriasis and vitamin D, but as you state, it's not necessarily a deficiency that triggers it. However, anecdotally there's people who do benefit from taking vitamin D3…

True, and I would never go as far as saying that the benefits have been disproven . I do hear about many people trying to treat their psoriasis wit vitamin D, but not about many success stories. As far as we know, the reason sunlight helps psoriasis is not vitamin D, but because UVB at specific wavelengths has an immunosuppressive effect on the skin. It induces apoptosis of T-cells and promotes keratinocyte different…

> I do hear about many people trying to treat their psoriasis wit vitamin D, but not about many success stories.

It seems to my non-expert opinion that it's a piece of the puzzle, but there's a lot more other pieces. It seems to be often linked with selenium deficiency and I've read one case of a really bad erythrodermic patient that was treated with calcium.

Re: Story of Vitamin D Toxicity (2022)

#163

Post by hwillis »

Aloisius wrote: post #125
hwillis wrote: post #105

Earlier quoted context omitted.

> "A whole body exposure to UVB radiation inducing the light pink color of the minimal erythema dose for 15–20 min is able to induce the production of up to 250 μg vitamin D (10,000 IU)"[1] So when you expose someone to light until they get a sunburn, they produce up to 250 ug. 80 ng/ml serum is still equivalent to 400+ ug and that's in the blood alone. The real issue is that over time that elevation caused calcium l…

> current day black Africans would have higher levels than the RDA- they wear shorts and tshirts, so they should still have >50% of prehistoric levels. Shorts and t-shirts? Em, a rather large amount of modern urban African spends most of their day indoors and wears long-sleeved shirt/pants/long dresses/long robe/hijabs/etc. I'm not sure why one would expect them to have >50% of prehistoric levels. The paper you linke…

It's an insincere argument

It's not reasonable to connect vitamin D to anything 100k years ago when vitamin D is so heavily influenced by diet and weather, both of which changed wildly. Lactose tolerance, megafauna, fishing, the last glacial maximum- just 20,000 years ago people were undergoing massive differentiation in vitamin D production and utilization.

Re: Story of Vitamin D Toxicity (2022)

#164

Post by lambdaba »

dkarras wrote: post #142
lambdaba wrote: post #46

Earlier quoted context omitted.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811610/ Figured people can Google, all I bring is awareness this is widely overblown, having taken myself, for therapeutic purposes, upwards of 100k IU per day for months without doctor supervision (but doing it correctly, with a very low calcium diet). People take vit D megadoses for autoimmunity, with significant success, but I'm not discussing this here.

>People take vit D megadoses for autoimmunity, with significant success, You mean for compensating for the low vit D levels due to constant inflammation seen in autoimmunity? or to decrease autoimmunity? I have autoimmune diseases and my vit D goes down to about 7 ng/mL without supplementation, so I'm curious.

That's the same level I had when I got very ill, it's near the bottom half of the insufficiency range, you should definitely consider supplementing and monitoring it.

Per your question, the latter, the theory is autoimmunity is exacerbated in a certain genetic makeup, and to compensate for it by megadosing.

Re: Story of Vitamin D Toxicity (2022)

#165

Post by eukaryote »

ndsipa_pomu wrote: post #76

I'm currently taking 10,000IU per day in an effort to control psoriasis, but it's a bit of guess work really and trying stuff to see what helps. It's somewhat annoying that I've had a dermatologist order some blood tests, but they were only targeted for whether I can safely take acitretin (a retinoid). I wish there were cheap home-tests for various blood levels of minerals and vitamins like there are for things like…

I successfully treated my eczema with Vitamin D. It did take several months to clear up, but now I can eat what I want with no risk of a flare-up. I took 5000IU daily. I still take it now, but only a couple of times a week.

It doesn't work for all cases of eczema or psoriasis, unfortunately; many people I have recommended it to did not have the same response.

Best of luck - I hope your Vitamin D experiment works out for you!

Re: Story of Vitamin D Toxicity (2022)

#166

Post by uslic001 »

JohnMakin wrote: post #4

I struggle to believe that a physician told her to take 5000 IU of vitamin D daily for 5+ years. This is nearly 10x canada's recommended winter time dose for adults under 70. After years of struggling with severe joint pain and mental fog/depression, among other things it was discovered that I had critically low vitamin D. They prescribed the 5000 dose but told me at least 10 times how I should NOT continue this high…

I see primary care providers giving patients 25000 IU weekly for years on end and they come in with toxicity.

Re: Story of Vitamin D Toxicity (2022)

#167

Post by veunes »

alyandon wrote: post #9
JohnMakin wrote: post #4

I struggle to believe that a physician told her to take 5000 IU of vitamin D daily for 5+ years. This is nearly 10x canada's recommended winter time dose for adults under 70. After years of struggling with severe joint pain and mental fog/depression, among other things it was discovered that I had critically low vitamin D. They prescribed the 5000 dose but told me at least 10 times how I should NOT continue this high…

I was diagnosed with low serum levels of vitamin D so I take daily supplements. The general guidance for my condition is 1000 IU daily. At one point in time, I discovered I had been taking 5000 IU/day instead of 1000 IU/day for about 180 days because of the bottles being identical except for the dosage printed in Flyspeck Times Roman 4pt. Fortunately, I alerted my doctor and a followup blood test confirmed I was stil…

Yeah, it's vital to be careful with these vitamins

Re: Story of Vitamin D Toxicity (2022)

#168

Post by t0bia_s »

alyandon wrote: post #9
JohnMakin wrote: post #4

I struggle to believe that a physician told her to take 5000 IU of vitamin D daily for 5+ years. This is nearly 10x canada's recommended winter time dose for adults under 70. After years of struggling with severe joint pain and mental fog/depression, among other things it was discovered that I had critically low vitamin D. They prescribed the 5000 dose but told me at least 10 times how I should NOT continue this high…

I was diagnosed with low serum levels of vitamin D so I take daily supplements. The general guidance for my condition is 1000 IU daily. At one point in time, I discovered I had been taking 5000 IU/day instead of 1000 IU/day for about 180 days because of the bottles being identical except for the dosage printed in Flyspeck Times Roman 4pt. Fortunately, I alerted my doctor and a followup blood test confirmed I was stil…

4000 UI is recommended for adults by many doctors.

https://vitamindforall.org/letter.html

I take 5000 UI D3 daily from October to March and blood test are fine. I wouldn't take it during sunny times if you spend decent amount of time outside.

Re: Story of Vitamin D Toxicity (2022)

#169

Post by t0bia_s »

toxicdevil wrote: post #109
JohnMakin wrote: post #55

Earlier quoted context omitted.

I should clarify by what I obviously meant that doctors would not recommend that as a DAILY dose - daily implying long-term use is okay.

I was prescribed 3-5000 iu daily and then I changed doctors. When I asked about continuing the vitamin the new doctors said "I won't recommend doing a test because almost everyone has low vit d levels, even with daily supplements. Just keep taking the pills. As long as its not a very high dose you should be fine". My wife has a different doctor who does regular vitamin testing, she was prescribed 5000iu and a year an…

Supplements never replace beeing outside exposed to sun where your body got vit. D naturally.

Re: Story of Vitamin D Toxicity (2022)

#170

Post by ozim »

ein0p wrote: post #145
ozim wrote: post #100

Earlier quoted context omitted.

From the article: * Of course, there is a selection bias in who comes to me. There are people out there doing just fine on 5000 units of Vitamin D daily. I only see the ones who develop high calcium levels. But I see enough of them to know that this is not an exceptionally rare occurrence. I have been to lectures in which physicians have claimed that Vitamin D toxicity almost never occurs. In my experience, this is f…

They make it sound like 5000IU is something astronomical when in reality for many people who live in the less sunny climates and have office jobs this is the normal amount. Still, one needs to test in order to see what _their_ normal amount is

It is astronomical if you take it every day for 5 years.

It is not if you take it during winter months.

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