Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

medicalxpress.com

Post reply on HN
Print view View original

131–140 of 205 posts

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#131

Post by kuschkufan »

jlhf wrote: post #110
brettv2 wrote: post #101

Earlier quoted context omitted.

> I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?" Your question isn't refuting OPs claim: the people you are observing to be fat are fat because of their carb/sugar intake, not fat. i.e. if you just fed someone large amounts of protein and fat they would be lean; it is the sugar and carbs that make them fat.

No they wouldn’t stay lean. If you fed someone more calories than their body uses to maintain its current weight, they would get fat eventually. Regardless of whether they eat carbs, fat or protein.

Let's say you're being fed just the amount of calories your body needs to maintain. What influence on body fat has the distribution of carbs, protein and fat from food then?

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#132

Post by zamalek »

iforgotpassword wrote: post #90
caymanjim wrote: post #72

Earlier quoted context omitted.

The idea that eating fat leads to higher body fat is the most dangerously-wrong health misconception in history.

Honest question: how? I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?" While the inverse occasionally has been true, generally people who I consider in good shape appear to eat less, and less greasy food. So while there might be exceptions it seems to be a damn good rule of thumb to me.

> I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?"

Are they eating fat _or sugar?_ The body will aggressively squirrel away any unused sugar as fat. As one example, a Big Mac contains 7g of _added_ sugar. Fries? Coated in dextrose. Sugar is added to damn-near everything.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#133

Post by smeej »

mobilejdral wrote: post #99
ProjectArcturis wrote: post #21

As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.

Can I ask you your thoughts about CYP21A2? Been studying folks with only one working CYP21A2 due to the resulting atypical adrenal function and I noticed that their dna also contains all the genetic variants associated with Alzheimer's (some are beneficial in this case). Inquiring about the family tree of the single CYP21A2 I have yet to have someone tell me of an ancestor that died of Alzheimer's. But the family mem…

I'm really uninformed about this topic, but I'll second the request for info about this!

I have Alzheimer's on three sides of my family (really banking on the fact that I take after the 4th grandmother who was sharp as a tack till 98), and while I haven't ever looked into a diagnosis of hypercorticolism, thanks to very early (in utero/neonate) trauma, my parasympathetic nervous system never learned how to clear cortisol like it should, which I'm working to remediate now.

I've been operating under the assumption that Alzheimer's is a high risk in my future, but I'd love to know more about what any experts would say I could even try to do by lifestyle change or preventative treatment!

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#134

Post by HlessClaudesman »

hkt wrote: post #123
ProjectArcturis wrote: post #21

As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.

Silly question, but could this be aided by simply reducing body fat down to extremely low levels?

Let's not jump to interventions just yet because prolonged low body fat comes with it's own set of serious health risks.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#135

Post by amelius »

ProjectArcturis wrote: post #21

As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.

Perhaps a stupid question but why wasn't this found earlier after examination of brain tissue?

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#137

Post by ineedaj0b »

ffgjgf1 wrote: post #88
ineedaj0b wrote: post #83

Earlier quoted context omitted.

If he’s not smart why’s he so successful. Why did he have a job hosting fear factor. A job hosting UFC. A job being a stand up comic. He’s also short - which I thought meant the cards are stacked against you? He also has a black belt. They don’t give those out. He currently has the biggest, arguably most successful podcast of all time. But he’s not smart right? Years and years of winning but he’s not smart. You are c…

> Why did he have a job hosting fear factor. A job hosting UFC That has no relationship with someone being able to have meaningful discussions on complex topics. Probably even the opposite..

You don’t get a job in front of camera unless you’re good looking or talented. Rogan was not good looking.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#138

Post by simonbarker87 »

iforgotpassword wrote: post #90
caymanjim wrote: post #72

Earlier quoted context omitted.

The idea that eating fat leads to higher body fat is the most dangerously-wrong health misconception in history.

Honest question: how? I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?" While the inverse occasionally has been true, generally people who I consider in good shape appear to eat less, and less greasy food. So while there might be exceptions it seems to be a damn good rule of thumb to me.

People get fat through consuming more calories than they burn for energy during the day. There are extra but around the edges but no matter the ratio of fat to carbs to protein, if someone consumes (food or liquid) 3,000 calories a day but only burns 2,500 calories a day then a decent portion of that 500 cal difference will get stored as body fat. You could eat 0 calories of fat but if that total of carbs and protein is over your energy burn then over time you will add body fat.

I believe most people gain excess body fat through eating a little bit more than they need each day and then two or three weeks a year they eat and drink much more (holiday, Xmas, birthday etc), rather than consuming vast amounts of food day in day out of the wrong macro nutrient make up.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#139

Post by jbd0 »

jlhf wrote: post #110
brettv2 wrote: post #101

Earlier quoted context omitted.

> I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?" Your question isn't refuting OPs claim: the people you are observing to be fat are fat because of their carb/sugar intake, not fat. i.e. if you just fed someone large amounts of protein and fat they would be lean; it is the sugar and carbs that make them fat.

No they wouldn’t stay lean. If you fed someone more calories than their body uses to maintain its current weight, they would get fat eventually. Regardless of whether they eat carbs, fat or protein.

You're so wrong. With only protein and fat, they would not be able to gain much weight. I've tried to gain weight on low carb/high fat, and it doesn't work. I was uncomfortably full after every meal. My tracking showed a significant calorie surplus, but my body wasn't absorbing it. Adding in more carbs made a huge difference. Hormones tell your body when to store fat.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#140

Post by imtringued »

iforgotpassword wrote: post #90
caymanjim wrote: post #72

Earlier quoted context omitted.

The idea that eating fat leads to higher body fat is the most dangerously-wrong health misconception in history.

Honest question: how? I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?" While the inverse occasionally has been true, generally people who I consider in good shape appear to eat less, and less greasy food. So while there might be exceptions it seems to be a damn good rule of thumb to me.

Your body can't take fat from plants and animals and directly embed it into fat calls. The metabolism of ingested fat takes much more steps than say sugar, which can be directly absorbed into fat cells and also raises insulin resistance. Sugar and refined carbohydrates are a far bigger reason for obesity than fat consumption or "greasy food".
Post reply on HN