Is this correlated with obesity demographics, i.e. Japan/US/EU statistics? I can’t find reliable numbers per country, most sources conflate the different types into dementia.
Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
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Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#72As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.
What kind of fat is it? Like is it possible to avoid by avoiding too much fat?
The idea that eating fat leads to higher body fat is the most dangerously-wrong health misconception in history.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#73Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#74Earlier quoted context omitted.
There is a weird crowd of people on the internet that have convinced themselves that seed oils are the cause of many ailments. It doesn’t have a ton of scientific backing but Joe Rogan promoted some guru doctor a while back that spread the idea to a lot more people.
>Joe Rogan promoted You mean he did an episode where he had a conversation with the doctor? Or was the doctor a sponsor of the show where he advertised products? I don't think simply having a conversation about an idea counts as promotion. Advertising is another matter though..
The problem with Joe Rogan is that he's not smart and his audience is not smart. He's a pseudo-intellectual. He gifts crackpots an enormous audience of gullible people. He lends credibility to them with softball interviews devoid of critical analysis. He's spoon-feeding suckers what they want to hear. He couches it all in a thin veneer of balanced reporting and barstool philosophizing, under the guise of fairness, but he's elevating ideas that have no business being elevated. It's even worse than outright promotion.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#75So, is this why fasting sometimes seems like a solution? Edit: Oversimplified, but: Less, calories, less fat? Excess calories, more fat?
Fasting seems like a solution because in the fasted state your body doesn't need to produce insulin. Your body needs insulin to push fat into cells. Your pancreas gets a break, and perhaps sensitivity improves when you go on an extended insulin-free holiday.
I'm no biologist but it's my understanding that insulin causes cells take up glucose, not fats. And I don't see anyone suggesting insulin or the pancreas is involved in any of this. So what does the pancreas have to do with Alzheimers?
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#76Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#77Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
If it does boost that hypothesis, what then? Are there things you can do aside from the basic focus on diet, exercise, and sleep?
Peptides.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#78Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#79My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?
This is a shot in the dark. My dad passed from dementia. That’s the best diagnosis we got. He wouldn’t go in under an MRI machine. He had horrible , infected teeth. They were badly infected. There’s linkage of poor oral hygiene and Alzheimer’s. https://www.health.harvard.edu/mind-and-mood/good-oral-healt... If I had know this sooner, I would have pushed harder for him to have those bad teeth extracted and had him sta…
Could the consumption of too many carbohydrates have led to your dad's teeth issues?
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#80Earlier quoted context omitted.
Right - but even then, if a super fit endurance athlete stops exercising, they don't immediately become diabetic. The upstream cause (what biochemical stimulus is driving the fat deposition?) is probably where the key insight lies.
If I recall correctly there were some studies that actually showed endurance runners have higher type 2 diabetes risk. And the suspect cause was the diet, specifically the carb loading practice and the abuse of high sugar products during the activity. So the three categories may actually share the same baseline, insulin resistance. It was quite controversial when it emerged (see Tim Noakes story), not sure if it's mo…
This is very interesting to a diabetic like myself, who is slightly underweight.
I've even had some people tell me I can't be diabetic because I don't have much, if any, extra fat.