Earlier quoted context omitted.
What kind of fat is it? Like is it possible to avoid by avoiding too much fat?
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Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
51–60 of 205 posts
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#52Earlier quoted context omitted.
Fasting seems like a solution because in the fasted state your body doesn't need to produce insulin. Your body needs insulin to push fat into cells. Your pancreas gets a break, and perhaps sensitivity improves when you go on an extended insulin-free holiday.
Except there's literally a result out this week linking fasting (specifically 16+ hour intermittent fasting) with a 91% increase in cardiovascular disease deaths, which if it holds up would utterly swamp any incremental improvements to alzheimers risk. No free lunch in personal health decisions, alas. Really the only good advice is stick to well-established science, be healthy in general, avoid internet advice, and d…
The results unfortunately are too vague to support that interpretation.
There was no causal linkage because they couldn't determine why people were fasting: suppressed appetite due to illness, suppressed appetite due to being a smoker (which is very common), skipping meals due to poverty.
It also found that while cardiovascular deaths increased by 91% overall deaths were completely unchanged...which is a bit difficult to reconcile.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#53Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#54Earlier quoted context omitted.
What kind of fat is it? Like is it possible to avoid by avoiding too much fat?
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I’m on the same page as you regarding the anti-“saturated animal fats” crowd, but I actually don’t mind them. My animal-based cooking oil spend would be a lot higher if everyone stopped buying plant-based oils.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#55Paul Saladino has been saying this for over 5 years but people ignore him because he's often shirtless and eats lots of protein.
Paul Saladino has been saying that APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia?
Are you being serious?
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#56Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
Plausible. I think this was also addressed in the work of Christopher Palmer. https://brainenergy.com/ “Mental disorders are metabolic disorders of the brain”
All of them?
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#57My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?
> My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?
Similar to ASCVD it takes decades to manifest and lots of the traditionally healthy lifestyle activities help delay or prevent it (diet, sleep, exercise). Unfortunately once someone is showing symptoms it's very late in the game.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#58Earlier quoted context omitted.
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That seems like a needlessly bitter response, why the antipathy?
There is a weird crowd of people on the internet that have convinced themselves that seed oils are the cause of many ailments.
It doesn’t have a ton of scientific backing but Joe Rogan promoted some guru doctor a while back that spread the idea to a lot more people.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#59Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
There's a really interesting paradox where, compared to healthy adults, intramuscular lipid droplet storage near mitochondria is increased in: 1) People with obesity 2) People with type 2 diabetes 3) People who do endurance exercise Even though #3 is highly protective against #1 and #2. The best explanation I've seen is that the important difference is why the lipid droplets are being deposited [1] [1] https://link.s…
Doesn’t diabetes mean that the cells has to extract more energy from those lipid droplets instead of from the glucose pathway impacted by the diabetes? Thus in the cases of 2 and 3 those droplets is an additional significant source of energy.
I also think that in the case of 1 the cells may be starving on glucose pathways (pre-diabetes), similar to 3 during the exercise and to 2 in regular situation, and that causes the over-eating while all that food doesn’t feed the cells because of the original issue and thus goes into fat for storage and into the lipid droplets way of feeding the cells to workaround the original glucose pathway issue.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#60Earlier quoted context omitted.
That seems like a needlessly bitter response, why the antipathy?
There is a weird crowd of people on the internet that have convinced themselves that seed oils are the cause of many ailments. It doesn’t have a ton of scientific backing but Joe Rogan promoted some guru doctor a while back that spread the idea to a lot more people.
>Joe Rogan promoted
You mean he did an episode where he had a conversation with the doctor? Or was the doctor a sponsor of the show where he advertised products?
I don't think simply having a conversation about an idea counts as promotion.
Advertising is another matter though..