So the takeaway is that more than zero but fewer than six cups is better than none or greater than six cups?
We need to know whether this means real cups for the bullshit "cups" commonly used to measure coffee were used in the study.
High coffee consumption, brain volume and risk of dementia and stroke
81–90 of 142 posts
Re: High coffee consumption, brain volume and risk of dementia and stroke
#82Earlier quoted context omitted.
Doesn't coffee impact sleep quality as well? At 6 cups a day, I'd expect some caffeine left in the body when sleeping.
Twelve hours to metabolize. The six cup people are totally jacked.
Half-life of six hours, so after twelve hours, one quarter of the caffiene will still be in the blood.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#83The article is not claiming causal link, but this is still interesting. >After full covariate adjustment, consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1–2 cups/day Coffee is stimulant just like some Alzheimer medications used to treat symptoms. It would be interesting to see if people increase coffee consumption with cognitive decline.
Considering the very early effects of dementia start to impact people sometimes decades before it becomes bad enough that they are diagnosed, it's certainly possible that extreme coffee consumption is some kind of self-medication mechanism. Anecdotally, I've seen this a lot with adults with undiagnosed ADHD (including myself until 26). Caffeine can be a (very shitty) alternative to proper stimulant medication that pe…
> Anecdotally, I've seen this a lot with adults with undiagnosed ADHD (including myself until 26). Caffeine can be a (very shitty) alternative to proper stimulant medication that people don't realise they actually need because of a medical issue. So the end up drinking 4-5 coffees a day instead.
ADHD medication is among the hardest to get in the first place, and to maintain in many places.
I was diagnosed as a child, and still couldn't get regular medication until 3 years ago (I'm 37 now). Doctors will try to push off-label treatments, often SSRIs, which do nothing for ADHD. They will push people to try ineffective talk therapy and describe actual medication as "only a last resort".
My cousin can't get it because his insurance says you only have ADHD if you were diagnosed as a child, and he spent his childhood in another country where the roads were barely maintained.
ADHD meds reduce the chances someone will abuse drugs according to research, but many docs will cancel prescriptions if you are honest about cannabis use.
In the wake of the opiate scandal new restrictions also place limits on how much a pharmacy can dispense, even if everyone has a valid prescription. That's part of the reason for the medication shortages in some areas.
It's been a miracle medication for me, but if you don't have money and luck it can be next to impossible to find someone to help you. Those that do often require thousands in fees.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#84Earlier quoted context omitted.
I've looked for this, the BioBank screen is this: https://biobank.ndph.ox.ac.uk/showcase/refer.cgi?id=100319 There is literally no guidance AFAICT. My best estimate is 8 US fl oz as per ChatGPT British still use cups to refer to that sometimes. And caffeine... it varies even from cup to cup, the estimate of 91mg per 8 oz cup is what I use.
Per the article, "Habitual coffee intake was self-reported as cups per day, as part of the touchscreen questionnaire at base line with the question ‘How many cups of coffee do you drink a day?’ " Sounds like it's based on the colloquial definition, which means... who knows! Self-reported values are very non-specific, since my definition of a 'cup' could mean a 24oz with an added triple shot... or it could mean a weak…
It will average out, so we will need to ask a British person what size an average cup of coffee is.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#85Just had Death Wish coffee for the first time. This is gonna be interesting.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#86> consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1–2 cups/day (fully adjusted OR 1.53, 95% CI 1.28, 1.83) 6+ cups! That’s a cranial marinade.
The scientific definition of a 'cup' of coffee is important. Usually this is defined as 4 ounces of brewed coffee, which means a normal mug of coffee (which can fit something like 10 oz) would be 2.5 cups! So, for most people's definition of a 'cup' of coffee, they really only mean 2.5 'mugs' of coffee.
True but I think the coffee machine definition of 4-5oz per coffee “cup” usually also assumes a stronger European strength of coffee which is quite concentrated. Most Americans seem to make coffee larger but more watered down, so it could be back to a 10oz mug is 1 or 1.5 cup equivalents.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#87Earlier quoted context omitted.
Considering the very early effects of dementia start to impact people sometimes decades before it becomes bad enough that they are diagnosed, it's certainly possible that extreme coffee consumption is some kind of self-medication mechanism. Anecdotally, I've seen this a lot with adults with undiagnosed ADHD (including myself until 26). Caffeine can be a (very shitty) alternative to proper stimulant medication that pe…
Wasnt this study made in the UK where most people lack vitamin D, which is also associated with dementia and depression?
It's 20% incidence in general, highest in Asian (Indian etc) communities - not completely correlated with melanin.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#88Earlier quoted context omitted.
Perhaps someday we'll discover a coffee tolerance gene.
The gene is called CYP1A2 with two variants. One variant is a rapid caffeine metabolizer. The other is a slow caffeine metabolizer. https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/ I have the rapid variant but could not sleep well on 6 cups.
Slow metaboliser here. If I drink a coffee at 11am my heart rate rises and doesn't return to normal until the following morning.
There are other genes for it too, like one that affects the degree to which coffee causes anxiety. And plenty of others that we haven't found, presumably.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#89Earlier quoted context omitted.
Wasnt this study made in the UK where most people lack vitamin D, which is also associated with dementia and depression?
It's 20% incidence in general, highest in Asian (Indian etc) communities - not completely correlated with melanin.
A bit of a sidenote, but I find it fascinating how little vitamin deficiencies are accounted for in allopathic medical contexts.
Deficiencies seem like such a frequent occurrence but most patients end up needing to self-medicate.
Re: High coffee consumption, brain volume and risk of dementia and stroke
#90Earlier quoted context omitted.
Per the article, "Habitual coffee intake was self-reported as cups per day, as part of the touchscreen questionnaire at base line with the question ‘How many cups of coffee do you drink a day?’ " Sounds like it's based on the colloquial definition, which means... who knows! Self-reported values are very non-specific, since my definition of a 'cup' could mean a 24oz with an added triple shot... or it could mean a weak…
It will average out, so we will need to ask a British person what size an average cup of coffee is.
Brit here, an average cup of coffee would be around 1 heaped tsp of instant coffee in a 300ml mug with a bit of breathing room, say 275ml? But that would include the milk, so maybe around 200ml water and 75ml of milk. Would vary quite a lot from person to person though.