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Alzheimer’s cases tied to no-longer-used medical procedure

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Re: Alzheimer’s cases tied to no-longer-used medical procedure

#201

Post by mips_r4300i »

twothamendment wrote: post #197
elzbardico wrote: post #116

Earlier quoted context omitted.

We can't conclude that the donor had an egg allergy. The immune system is complicated as hell, it could be the case that he had some weird protein circulating on his blood that was recognized by her immune system, and by chance this protein was structurally close enough to some egg protein that now eggs trigger an immune response on her.

"The immune system is complicated as hell." You got that right! My wife used to eat a banana every day. Then something in her flipped and she reacts as if she is allergic to bananas and the rest of the world - not exaggerating. She can eat a very small number of foods and has to avoid most people because of smells. It isn't allergies it is - you guessed it - her immune system. If we could just flip it back to "normal…

Same thing happened to me. I was eating bananas, beef, coffee, etc. then I got some sort of viral infection. My thyroid became inflamed for a couple months. No doctor was able to find anything wrong with me.

Little did I know, having postviral sequelae causes my immune system to start hating many things I used to eat. A food blood sensitive test showed that bananas, beef, coffee were what set my immune system off the most.

I was told it was gut permeability causing food particles to leak into the blood stream causing the immune response. So the fix has been to stop eating those, let the gut heal, and over time I've been able to eat those foods in moderation years later.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#202

Post by TechnicalVault »

bobsmooth wrote: post #97
kccqzy wrote: post #73

Earlier quoted context omitted.

Generally, I think if a patient needs blood transfusions there's a bigger and more immediate life-and-death problem right there. I think allergies would be preferable to death. Is my understanding correct? I hope blood transfusion hasn't become a routine procedure these days.

You get a blood transfusion for any major surgery.

Before the 1990's but not anymore. The contaminated blood scandal in the United Kingdom (https://www.infectedbloodinquiry.org.uk/) and a lot of papers showing benefits to avoiding blood loss in the first place have changed practices. We haven't eliminated the use of allogeneic blood transfusions but they're indicated a lot less than they used to be.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#203

Post by kvgr »

emayljames wrote: post #190
diob wrote: post #26

Earlier quoted context omitted.

It mentions brain proteins contaminating it, makes me think of prions.

What I found odd, is in the article it talked of the importance of sterilising medical tools used, that may have had prions on them. Prions can't even be destroyed by extreme temperatures, they are extremely scary.

Over 900c for several hours vs 250 in autoclave... if Alzhaimers can spread this way, i am done, because I spent days in dentist chair...

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#205

Post by ImPostingOnHN »

BurningFrog wrote: post #198
tim333 wrote: post #171

Earlier quoted context omitted.

Though it seems quite plausible something in the blood caused an immune reaction that then also gets set of by egg protein.

FWIW, ChatGPT 3.5 says: "The development of a new food allergy, such as an allergy to eggs, as a direct result of a blood transfusion is extremely rare and not a well-documented phenomenon. Food allergies are typically triggered by exposure to specific allergenic proteins found in foods, and blood transfusions do not typically involve the introduction of food proteins."

ChatGPT 3.5 is known to make mistakes, hallucinate, and not care about the factuality of its responses.

Given this, a comment which does nothing but quote chatGPT 3.5 verbatim can do more harm than not commenting at all, especially on health matters, where such qualities can constitute outright recklessness.

If you want to share your own thoughts, though, I know I'd welcome them. At least humans have a greater than 0% chance of caring about the well-being of humans.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#206

Post by RugnirViking »

pvaldes wrote: post #160
mbo wrote: post #127

Earlier quoted context omitted.

"w/" is an abbreviation for "with". "w/ mice" should be read as "with mice".

The savings of just two characters does not worth the effort and mental pause to decode it

it's an exceptionally common way of writing with and without. similar to "etc." standing for "et cetera." at some point you don't "decode" it, thats just what it means.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#207

Post by timschmidt »

wisty wrote: post #184
timschmidt wrote: post #169

Earlier quoted context omitted.

Seed oils like canola aren't great for health. They're fairly new to the food stream (only widely available since about 1900), heavily processed, and chock full of compounds the plant was making to protect it's seeds, many of which cause inflammation and other negative health effects. Olive oil, coconut oil, and animal fats have all been in use longer, and seem to be better for us. Avocado oil also seems to be decent…

Any proper evidence or is this just some internet meme? https://www.consumerreports.org/health/healthy-eating/do-see...

You're welcome to eat the non-food. I won't stop you.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#208

Post by Zigurd »

bjourne wrote: post #8

Afaict, this is not an entirely new finding. For example, this page ( https://www.nature.com/articles/d41586-018-07771-6 ) references a 2018 article about the issue of Alzheimer's being transmitted (or rather "seeded") through growth hormone extracted from cadavers. Perhaps the new article provides additional evidence or perhaps the other article only suspected a casual link and this one proves that there is one. I h…

Prions are exactly the tiny, hard to detect things that could make Alzheimers transmissible. There are likely to remain many questions to resolve, but this sure suggests a line of inquiry: Is Alzheimer's one distinct disease? Can a prion be isolated as the cause? Can a diagnostic test be designed that detects this prion? Etc.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#209

Post by adrian_b »

meepmorp wrote: post #199
emayljames wrote: post #191

Earlier quoted context omitted.

And CJD came about from farmers using ground and processed cow brains to feed cows. What could possibly go wrong feeding a cow some cow brains!

There's a human prion disease, kuru, which was caused by the practice of funerary cannibalism - where family would ritually consume parts of their deceased relatives' bodies. The moral of the story seems to be, don't eat brains.

Which is rather unfortunate.

I no longer eat meat, but when I was younger I considered the brains as the tastiest part of an animal, when properly prepared and cooked.

It is said that in USA eating organs is not very popular, so it is likely that many have never experienced well cooked brains, to know what they are missing.

There exists a hypothesis that is rather plausible, that breaking bones and eating their content of brains and marrow has played an important role in the evolution of humans, by providing an abundant source of long-chain fatty acids, enabling the unusual mass ratio between the central nervous system and the whole body that characterizes humans.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#210

Post by rsynnott »

aeternum wrote: post #88
lostlogin wrote: post #40

Earlier quoted context omitted.

> I've seen some interesting research about the "signalling" power of blood from both older and younger donors, with the "young blood" causing a slow down of senescence in cells Maybe the Silicon Valley ‘blood boy’ can be brought to market.

I believe Ambrosia was the (real) startup that was the inspiration for that story arc. Looks like they're still around but have pivoted to boring wearables and of course AI. A supposed win for the FDA, but perhaps a loss to humanity since there does seem to be evidence that the idea actually worked.

For once, a pivot to AI is a bit of a relief...
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