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Alzheimer’s cases tied to no-longer-used medical procedure

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Re: Alzheimer’s cases tied to no-longer-used medical procedure

#171
post #38

Earlier quoted context omitted.

My mom developed an allergy to eggs after a blood transfusion. She long regretted never being able to eat another chocolate eclair.

Killjoy note that the allergy may well be unrelated to the transfusion, despite occurring after it.

Though it seems quite plausible something in the blood caused an immune reaction that then also gets set of by egg protein.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#172

Earlier quoted context omitted.

> I've seen some interesting research about the "signalling" power of blood from both older and younger donors, with the "young blood" causing a slow down of senescence in cells Maybe the Silicon Valley ‘blood boy’ can be brought to market.

I believe Ambrosia was the (real) startup that was the inspiration for that story arc. Looks like they're still around but have pivoted to boring wearables and of course AI. A supposed win for the FDA, but perhaps a loss to humanity since there does seem to be evidence that the idea actually worked.

[deleted]

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#173
post #43

I wonder what other stuff is being unwittingly transferred during standard blood transfusions. I've seen some interesting research about the "signalling" power of blood from both older and younger donors, with the "young blood" causing a slow down of senescence in cells, and the "old blood" causing a speed-up in senescence. Any time you take biological material out of other human beings and put them in a different bo…

> I've seen some interesting research about [...] the "young blood" causing a slow down of senescence in cells, This is excellent material for the conspiracy theorists.

Yeah see https://techcrunch.com/2017/06/14/no-peter-thiel-is-not-harv...

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#174
post #137

Earlier quoted context omitted.

They still use pieces of cadaver for other surgeries. E.g. gum and bone transplants done by periodontists. Seems risky to me.

Periodontists have been also linked with a higher number of Alzheimer cases. Is a group of risk in this disease.

The doctor or their patients have the higher risk?

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#175

I thought the beta ameloid theory was largely debunked since the publisher had manipulated data. Now it's attached again? I'm so confused

It's complicated. Read all about it https://www.science.org/content/blog-post/faked-beta-amyloid...

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#176
post #7

Earlier quoted context omitted.

Not sure why scientists has to pin point a single cause where as you have different vectors that can cause the same disease is also plausible

They don't, but my surface understanding is that the medicines that effectively nuke beta amyloid have no effect overall. Which would mean it's not even one of many causes, it seems to not be a cause at all.

I think the medicines likely reduce beta amyloid rather than get rid of all of it which if it has a prion like mechanism wouldn't really fix things.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#177
post #174

Earlier quoted context omitted.

Periodontists have been also linked with a higher number of Alzheimer cases. Is a group of risk in this disease.

The doctor or their patients have the higher risk?

if I remember correctly Dentists had more cases of alzheimer than other groups of doctors. I heard it some time ago.

If is a prion, it should resist most sterilization of dental instruments by heat on autoclave. So is obvious IMAO that this could be a way to spread the disease from one patient to other, but I'm not an expert on clinic procedures and the protocols may have been updated. This is known, or at least suspected, since maybe a decade or so.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#178

This is really fascinating, horrifying and hopeful at the same time. It makes sense that some neurodegenerative diseases with unknown etiologies are caused by prions or prion-like proteins. It could be fruitful to study the rate of Alzheimer's among nursing assistants who work in elder care. I found a few resourcas stating a higher rate for caregiver's in general along with nurses. I have thought decreased immune fun…

From my limited understanding the blood brain barrier doesn't really stop things. However it is difficult to transmit from one person / animal to another usually resulting from things like transplants or being injected in.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#179
post #38

Earlier quoted context omitted.

My mom developed an allergy to eggs after a blood transfusion. She long regretted never being able to eat another chocolate eclair.

That’s nuts. Seems like researchers should look really closely at weird side effects of blood transfusions since these are effectively “natural experiments” that would be impossible or unethical to run normally.

As someone who has been deliberately used at a young age by a doctor for a medical experiment, I can tell you this is how human experiments are done these days. Take someone with condition X which is life threatening, and suddenly you can do all your unethical stuff without having to be afraid of consequences. You just have to crank up the severity and you suddenly are free to do whatever you want.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#180
post #147

Earlier quoted context omitted.

I don't think I ever had to declare allergies when donating my blood (France). They focus on infections and cancers I think. Why would they ask for allergies if we don't yet know that they can be transmitted like this?

I thought it was well known that certain allergies (eggs/peanuts) can transfer via transfusions? At least for awhile. It looks like there’s some literature on it at least, but I didn’t dig into it or anything. I just thought this was “common” knowledge since that’s what I was told years ago by a nurse I was dating in college, a long time ago.

I would assume things like that maybe after a bone marrow transplant but having a blood transfusion seems pretty mild I wouldn't expect any affects from it.
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