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Long Covid is associated with cognitive slowing

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Re: Long Covid is associated with cognitive slowing

#11

Post by thenerdhead »

treprinum wrote: post #7
thenerdhead wrote: post #2

These numbers don't look so great long term. Especially the no PCC group. The good news is that recent research suggests we can start aggressively targeting virus in trials: https://www.nature.com/articles/s41590-023-01724-6 https://www.medrxiv.org/content/10.1101/2023.07.27.23293177v... There are a lot of exciting trials going on for many different antivirals, monoclonal antibodies, immunomodulators/immunotherapy, a…

There was some recent study where most patients who received monoclonal antibodies regressed rapidly so I am not sure that's a good pathway. The hypothesis is that the covid antibodies are quite nasty so the body creates anti-antibodies that in turn resemble the original virus wrt certain effects and one ends up in a cycle of doom that first needs to be broken before one starts getting better.

Link the study.

Re: Long Covid is associated with cognitive slowing

#12

Post by rubicon33 »

Since 2019 I've been:

- Vaccinated for COVID once

- Infected with COVID 3 times

- Infected with RSV once

- Infected with unknown ?? upper respiratory, two times.

I am absolutely less "sharp". It feels like both my cognitive and physical ability have taken a serious blow. I'm far less creative, less excited about work, less interested in challenging topics, and less capable of solving complex problems.

I will sometimes stare at my IDE and find myself unable to write a single line. It takes minutes of reorienting my mind to find context again and beginning to put some stuff down.

And that's for languages and projects that I already know.

I'm trying to learn a new programming language now in a new domain, and finding it very challenging. I'm not sure if this is the direct result of COVID, or if it's just part of getting older... maybe it's both. All I can say is that it came on quickly and definitely feels like something changed in how my brain works. Sucks.

Re: Long Covid is associated with cognitive slowing

#14

Post by treprinum »

thenerdhead wrote: post #11
treprinum wrote: post #7

Earlier quoted context omitted.

There was some recent study where most patients who received monoclonal antibodies regressed rapidly so I am not sure that's a good pathway. The hypothesis is that the covid antibodies are quite nasty so the body creates anti-antibodies that in turn resemble the original virus wrt certain effects and one ends up in a cycle of doom that first needs to be broken before one starts getting better.

Link the study.

Can't find the paper as it was in 2021 but here is from someone who did it:

https://old.reddit.com/r/covidlonghaulers/comments/1acpmjc/i...

Re: Long Covid is associated with cognitive slowing

#16

Post by thenerdhead »

treprinum wrote: post #14
thenerdhead wrote: post #11

Earlier quoted context omitted.

Link the study.

Can't find the paper as it was in 2021 but here is from someone who did it: https://old.reddit.com/r/covidlonghaulers/comments/1acpmjc/i...

Are you referring to this preprint?

https://www.biorxiv.org/content/10.1101/2023.11.21.567575v1

Regardless, you trust a single redditor's comments with no verifiable proof over peer-reviewed science and on-going clinical trials?

Re: Long Covid is associated with cognitive slowing

#17

Post by wslh »

rubicon33 wrote: post #12

Since 2019 I've been: - Vaccinated for COVID once - Infected with COVID 3 times - Infected with RSV once - Infected with unknown ?? upper respiratory, two times. I am absolutely less "sharp". It feels like both my cognitive and physical ability have taken a serious blow. I'm far less creative, less excited about work, less interested in challenging topics, and less capable of solving complex problems. I will sometime…

The obvious answer to this that I believe you already know is to check with health specialists. The part of being older and/or changing interest is another factor to take into account.

Since we are slowly understanding more things about COVID and other diseases you can also try new things and no believe 100% in what is published. Trial and error is a good problem solving skill. For example, engaging in new activities that "play" with one or more of our senses (e.g. music).

Re: Long Covid is associated with cognitive slowing

#18

Post by treprinum »

thenerdhead wrote: post #16
treprinum wrote: post #14

Earlier quoted context omitted.

Can't find the paper as it was in 2021 but here is from someone who did it: https://old.reddit.com/r/covidlonghaulers/comments/1acpmjc/i...

Are you referring to this preprint? https://www.biorxiv.org/content/10.1101/2023.11.21.567575v1 Regardless, you trust a single redditor's comments with no verifiable proof over peer-reviewed science and on-going clinical trials?

It's one datapoint. Not sure why I should by default distrust somebody whose life was ruined by it and is essentially involved in a human-style reinforcement learning crowdsourcing trying to figure out how to recover by sharing what worked and what didn't.

Re: Long Covid is associated with cognitive slowing

#19

Post by hef19898 »

rubicon33 wrote: post #12

Since 2019 I've been: - Vaccinated for COVID once - Infected with COVID 3 times - Infected with RSV once - Infected with unknown ?? upper respiratory, two times. I am absolutely less "sharp". It feels like both my cognitive and physical ability have taken a serious blow. I'm far less creative, less excited about work, less interested in challenging topics, and less capable of solving complex problems. I will sometime…

Vaccinated three times, had it twice. The first time, no long term effects. The second time, well... I think it is getting better, but I feel you. Stuff I know I know the solution to, I know I can do in the blonk of an eye just seems to be hidden behind some wall of fog. Takes sheer willpower to get through that, then it is done in a heart beat. After that, my energy seems to be gone.

Wasn't a problem at work, for now.

Physically, well, I am low on stamina. Did hit the gym since, I don't feel like 2 hours of boxing are a particularly good idea at the moment.

Sucks, you are right. My significant other so told me it goes away, and sometimes I feel close to break through whatever that shit is. Still better of than a friends son: 10 years old, unable to follow school since October, unable to do more than 2 hours worth learning per day, unable to excercise. All this despite being fully vacinated three times, the second time Covid hit him, it hit hard. I can only imagine how it would be without vaccination...

Re: Long Covid is associated with cognitive slowing

#20

Post by thenerdhead »

sunshine_reggae wrote: post #15
thenerdhead wrote: post #13

Earlier quoted context omitted.

Over 14,000 published articles suggest otherwise: https://www.ncbi.nlm.nih.gov/research/coronavirus/docsum?fil...

Don't forget the use of bots, AI-generated articles, etc.

You can read more on this here:

https://academic.oup.com/nar/article/51/D1/D1512/6814452

Yes there are general challenges in research, but not sure how that really changes the argument that there's significant amounts of research in this area and novel peer-reviewed findings.

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