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Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

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Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#81

Post by epgui »

soudiere wrote: post #58
epgui wrote: post #21

Earlier quoted context omitted.

No. Adderall is normally prescribed in the XR formulation (meaning it's an extended/slow release capsule), and has amphetamine as the active ingredient. Methamphetamine is a different molecule altogether, and typically it's not packaged in slow-release capsules. Yes, methamphetamine is structurally related to amphetamine, but you shouldn't make the mistake to think they are interchangeable. Very often the difference…

Adderally XR formulations are still a minority of prescriptions. Talking about methamphetamine as a different molecule is not helpful, as Adderall itself is not a single molecule. Which I suspect you know, as you mention different enantiomers of thalidomide. However you don't point out that adderall itself is a 3:1 racemic mixture of l and d amphetamine. The real discussion here is the receptor binding affinity of th…

Racemic means 1:1. You can’t have a 3:1 racemic mixture.

The vast majority of adderall prescriptions are XR.

Enantiomers are structurally “the same molecule” (or people often speak this way depending on the context) but with different optical configurations.

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#82

Post by uxp100 »

epgui wrote: post #23
uxp100 wrote: post #3

Obviously not good, I’m just being a little glib. If correctly dosed I suppose people would be getting a somewhat more effective medication than they thought they were getting. Those who were getting caffeine or ibuprofen, not so much.

Why do you think methamphetamine would be more effective than amphetamines?

I was thinking of user surveys. There was a Slate Star Codex/Astral Codex Ten article that goes through different ADHD medications, and those who take Desoxyn report being happier with their medications performance. The article notes all the reasons to be skeptical, but there is some reason to believe meth is a better ADHD drug than Adderall.

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#83

Post by jasomill »

hotpotamus wrote: post #68
soudiere wrote: post #63

Earlier quoted context omitted.

Why does it blow your mind?

Imagining a doctor writing a script for meth is pretty amusing, and maybe if that’s not a cool enough drug, they can hand out some crack or something.

Cocaine, like methamphetamine, is a Schedule II controlled substance under US law, so has accepted medical uses.

As with meth, typical medical applications of cocaine don't involve smoking it (source: Wikipedia).

Legitimate US suppliers for smokable cocaine do exist, however, e.g.,

https://www.sigmaaldrich.com/US/en/product/sigma/c8912

In stock and available for shipping today* **!

* “This order may require review prior to shipping.”

** “DEA License Number required at checkout.”

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#84

Post by hotpotamus »

jasomill wrote: post #83
hotpotamus wrote: post #68

Earlier quoted context omitted.

Imagining a doctor writing a script for meth is pretty amusing, and maybe if that’s not a cool enough drug, they can hand out some crack or something.

Cocaine, like methamphetamine, is a Schedule II controlled substance under US law, so has accepted medical uses. As with meth, typical medical applications of cocaine don't involve smoking it (source: Wikipedia). Legitimate US suppliers for smokable cocaine do exist, however, e.g., https://www.sigmaaldrich.com/US/en/product/sigma/c8912 In stock and available for shipping today* **! * “This order may require review pr…

I've taken substances of various schedules legally and otherwise before, and I've never heard of a doctor writing a prescription for methamphetamine. I really wonder if they have it in stock at my local pharmacy.

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#85

Post by hkchad »

Areibman wrote: post #7

I just came back from Puerto Vallarta, and it's shocking how pharmacies advertise their drugs to tourists. I'm talking massive signs with every prescription med under the sun-- Adderall, Xanax, Retinol, you name it. All next to the HGH and testosterone posters featuring unreasonably muscular bodybuilders.

But you had better not bring a vape into customs!

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#86

Post by azdle »

trashface wrote: post #13
madars wrote: post #6

Earlier quoted context omitted.

DEA has a set cap for amphetamine production and demand is higher than the cap.

However DEA was claiming a few months ago that manufacturers had not used their allotted cap, so naturally the DEA did not raise it.

As far as I could tell reading that DEA memo, they were being really sneaky with what they said. None of the pill manufacturers had hit their allotment, but they didn't say anything about the raw ingredient manufacturers which are under a different quota. And most of the shortages I've seen in the FDA shortages database were listed as 'shortage of active ingredient'. (Or 'demand increase', which isn't specific enough to know that it's not literally the same thing.)

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#87

Post by bongodongobob »

soudiere wrote: post #56
bongodongobob wrote: post #32

Earlier quoted context omitted.

A. They aren't comparing it to rubbing alcohol. The analogy is that they are both alcohol so they are the same right? Obviously not. B. I've tried meth. It's nothing like Adderall and much, much more potent.

I've tried both as well, and I suspect your lying to yourself about potency. I certainly didn't have a scale to measure the dosage to match say a 10mg orange adderall pill. By analogy, if you did a 75ml "shot" of alcohol each day, and then had a mixed drink one day, you would think it's a lot more potent.

There's no way. I snorted a bump of approximately 50mg, at the most, off of my hand and was completely jacked for 48 hours. It was the most uncomfortable speedy high I've ever experienced. I drank an entire case of beer trying to come down and it did almost nothing. I've gone through a gram of coke in a night, snorted and/or smoked, and it was nothing compared to meth. I'm on 30mg Adderall daily and I can sleep just fine.

I remember thinking "Why would anyone want to feel like this?" Will never touch the stuff again.

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#88

Post by soudiere »

epgui wrote: post #81
soudiere wrote: post #58

Earlier quoted context omitted.

Adderally XR formulations are still a minority of prescriptions. Talking about methamphetamine as a different molecule is not helpful, as Adderall itself is not a single molecule. Which I suspect you know, as you mention different enantiomers of thalidomide. However you don't point out that adderall itself is a 3:1 racemic mixture of l and d amphetamine. The real discussion here is the receptor binding affinity of th…

Racemic means 1:1. You can’t have a 3:1 racemic mixture. The vast majority of adderall prescriptions are XR. Enantiomers are structurally “the same molecule” (or people often speak this way depending on the context) but with different optical configurations.

That is not what racemic means, ratios can exist.

There's a whole section, "Single-Isomer Versus Racemic Formulation", in this recent review article titled "Novel Formulations of ADHD Medications: Stimulant Selection and Management" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412159/

The psychiatry handbook of Massachusetts General Hospital also uses racemic in this context https://www.sciencedirect.com/science/article/abs/pii/B97814...

Also, I can't find any data on what percentage of Adderall prescriptions are XR, have you found anything?

Looks like the LRx database would be the place to look from scanning this report for the DEA. https://www.deadiversion.usdoj.gov/pubs/docs/IQVIA_Report_on...

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#89

Post by soudiere »

bongodongobob wrote: post #87
soudiere wrote: post #56

Earlier quoted context omitted.

I've tried both as well, and I suspect your lying to yourself about potency. I certainly didn't have a scale to measure the dosage to match say a 10mg orange adderall pill. By analogy, if you did a 75ml "shot" of alcohol each day, and then had a mixed drink one day, you would think it's a lot more potent.

There's no way. I snorted a bump of approximately 50mg, at the most, off of my hand and was completely jacked for 48 hours. It was the most uncomfortable speedy high I've ever experienced. I drank an entire case of beer trying to come down and it did almost nothing. I've gone through a gram of coke in a night, snorted and/or smoked, and it was nothing compared to meth. I'm on 30mg Adderall daily and I can sleep just…

You most likely did far more than 50mg of methamphetamine.

I just weighed a couple 20mg orange adderall pills, they're each around 0.2-0.3 grams (my scale is only accurate to 0.1g)

Re: Some Mexican pharmacies are selling full bottles of Adderall. But it's meth

#90

Post by soudiere »

hotpotamus wrote: post #80
soudiere wrote: post #76

Earlier quoted context omitted.

Why is it amusing? Because you think it has no therapeutic value?

I don’t see the point in playing obtuse here.

Not playing obtuse, trying to get you to say why you think it's so crazy.

Section 3 of this 2019 paper has stats on meth (desoxyn) prescriptions https://www.medrxiv.org/content/10.1101/2022.05.23.22275471v...

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