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Mid-old cells are a potential target for anti-aging interventions in the elderly

nature.com

101–110 of 121 posts

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#101
post #61

Earlier quoted context omitted.

More likely you'll see all people rent organs; surprisingly EVEN poor people don't usually like death.

Sure, Society in its majestic equality will allow rich and poor people alike to rent a new bio-heart with youthenating agents for 1 million dollars a month.

Kings died from infection and even criminals who practiced great evils are cured. You sound like you practice making scenarios where you're unhappy.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#102
post #52

Earlier quoted context omitted.

When I was a kid, people were already saying “100 channels and nothing worth watching” about satellite and cable. Do we need all the professional content creators of the modern age, or is that a hobby created by advertisers as an excuse for more adverts?

> is that a hobby created by advertisers as an excuse for more adverts Yes. It's just "content" to fill a box with the ads around it. "Content" can be anything. Generic.

Even our texts.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#103
post #87
post #76

Earlier quoted context omitted.

Equality is meaningless. Why should we not have the same amount of ears as noses? That is inequality. Why should we use one fork instead of two for equality of the use of our hands and symmetry? Why not our keyboards be mirrored and equal too?

the whole point of a democratic state is power to the many. Maybe not to all, but certainly not unequally.

That's not the point, and I doubt you live in a democracy. If you live in the US it's not even described as one.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#104
post #77

Earlier quoted context omitted.

So, potentially, we can synthesise this SLIT2 and inject people with a bunch of it?

That is, unfortunately!, not how these things work. But it allows people to do more targeted studies, and (many years of research later) perhaps find a drug that can have some impact.

Or sometimes we get really lucky and just find a food or spice that upregulates/downregulates the right gene or affects the right enzyme (e.g. ginger contains compounds that suppress the inflammation triggering enzyme COX-2 without affecting the related COX-1 enzyme, which is actually beneficial. Most inflammation-reducing drugs affect both).

Although I'm sure we'd have noticed it by now if a food item targeted these genes (assuming they do significantly affect how healthily people age).

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#105
post #51

Earlier quoted context omitted.

Its further evidence for a hypothesis on the mechanism of aging. Personally I just wanna know how aging works

Don't your telomeres get shorter, your DNA gets damaged and it doesn't replicate correctly anymore? Some animals can be immortal like lobsters but face limits like their physical size can kill them when they molt enough.

I'm not sure if this is one of the consensus primary causes but the most compelling explanation I've heard is capillary damage.

Red blood cells and capillaries have roughly the same diameter leading to constant friction. Your body repairs the capillaries but, given enough time, it makes mistakes. As these mistakes pile up your circulatory system, your body's supply chain, slowly gets less efficient. This leads to every cell in your body gets the energy it needs a little later, and has to hold onto waste for a little longer.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#106
post #71

Earlier quoted context omitted.

Carbon is very stable, so there's no life? I'm hearing 2deep4u 'philosophy' about the universe, nobody needs a condescending goofy sounding false prophet about how to think.

Carbon is created by nuclear fusion in stars. Thus, something has to perish for carbon to appear. Carbon is also mostly found as compounds in the universe, not as elemental form. Indeed, if carbon was stable as argon, there would be no life. Luckily it forms many volatile organic compounds which can be in an endless cycle of reorganizing. It's not some deep philosophy, it's basic science.

None of those Wikipedia facts will prepare someone for death. Reciting what psychedelics are or describing color with words would yield the same result. Why would that knowledge help someone prepare for death?

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#107
post #33

Sure, "the" elderly. Everyone who is suffering from aging will be helped. No special treatment for powerful people, it'll be all about "the elderly".

Why throw out the baby with the bath water, just because the rich will live longer, no one should. This is the feeling I get everytime I see a comment that it will be only for the rich and powerful. I don't think that will be the case, as there will be a gold rush once the possibility is proven and visible, everyone will try to get it, even the naysayers. It will be more like the crash of prices from the Spanish mine…

> This is the feeling I get everytime I see a comment that it will be only for the rich and powerful.

That's not a "feeling", that are words you put into my mouth, to then call it a "feeling" of yours. And that's the top voted reply. Just lol.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#108
post #77

Earlier quoted context omitted.

That is, unfortunately!, not how these things work. But it allows people to do more targeted studies, and (many years of research later) perhaps find a drug that can have some impact.

Or sometimes we get really lucky and just find a food or spice that upregulates/downregulates the right gene or affects the right enzyme (e.g. ginger contains compounds that suppress the inflammation triggering enzyme COX-2 without affecting the related COX-1 enzyme, which is actually beneficial. Most inflammation-reducing drugs affect both). Although I'm sure we'd have noticed it by now if a food item targeted these…

Thanks for the ginger example, it was tangential but gave me some ideas :-)

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#109
post #106

Earlier quoted context omitted.

Carbon is created by nuclear fusion in stars. Thus, something has to perish for carbon to appear. Carbon is also mostly found as compounds in the universe, not as elemental form. Indeed, if carbon was stable as argon, there would be no life. Luckily it forms many volatile organic compounds which can be in an endless cycle of reorganizing. It's not some deep philosophy, it's basic science.

None of those Wikipedia facts will prepare someone for death. Reciting what psychedelics are or describing color with words would yield the same result. Why would that knowledge help someone prepare for death?

Nothing can prepare a self-obsessed person for death. It is not my duty to prepare you for death or make it easy for you, it is my duty to be intellectually honest.

The tapestry of live consists of all the individual threads (lives) and if someone of those threads never ended, new threads cannot be in the space they occupy. That's trivially true. And to me that does the same to the tapestry of live what a cancer cell does to an individual body.

We already have shit like, let's say, old people starting a war of aggression over oil and profits for Halliburton et al, and then torture someone like Assange, who is still not free. And that's even though they'll only live for a few decades at most! If they knew they could potentially live hundreds or thousands of years, the gloves would come off in ways you cannot even imagine, and if that's "2deep4u" or "conspiracy theory" for you that's great, don't bother telling me.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#110
post #33

Sure, "the" elderly. Everyone who is suffering from aging will be helped. No special treatment for powerful people, it'll be all about "the elderly".

Why throw out the baby with the bath water, just because the rich will live longer, no one should. This is the feeling I get everytime I see a comment that it will be only for the rich and powerful. I don't think that will be the case, as there will be a gold rush once the possibility is proven and visible, everyone will try to get it, even the naysayers. It will be more like the crash of prices from the Spanish mine…

> "I don't think that will be the case, as there will be a gold rush once the possibility is proven and visible, everyone will try to get it, even the naysayers."

Maybe; instead when this happens, e.g. hairloss and finasteride, I look at people desperately trying to fight aging and stay young forever and then replacing their worry about hairloss with worry about post-finasteride[1] depression and sexual side effects. Or the people who are obsessed with nootropics ('smart drugs') who are in a hyper-competitive world I don't want to be in at all. Or the people who slather vitamin A creams on their skin to try and look younger who may give themselves retinol burn[2] and Vitamin A, E supplements to look younger which may[3] gives bone pain, liver damage, birth defects, increased risk of fractures, skin irritation, increased risk of prostate cancer.

[1] https://www.bmj.com/content/366/bmj.l5047

[2] https://www.healthline.com/health/retinol-burn

[3] https://www.nationalgeographic.com/premium/article/how-these... - "For context, consider that a single 3-ounce serving of pan-fried beef liver [alone] contains [over 2x the recommended daily upper limit of Vitamin A]."

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