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Mid-old cells are a potential target for anti-aging interventions in the elderly

nature.com

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Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#71

Post by graphe »

morbicer wrote: post #70
graphe wrote: post #37

Earlier quoted context omitted.

Sounds like an angry projection of your own value of your life. Its as if you're supposed to accept your death by 80, otherwise you'll... die and not accept it? Very few people that die 'made peace with their morality'. Why is it a prerequisite? How do you assign value to another person's life simply based on if they made you cringe or not? That's cringe.

The whole universe runs on decay & arise of the new. From stars through chemical compounds through cells to us humans. If the rotating cloud of gas and dust stayed forever, there would be no Earth. If the chemical compounds would be super stable, there would be no life. And so on. Systems are kept in equilibrium by this, otherwise they became unstable. Making space for the next, better entity is a cosmological princi…

Carbon is very stable, so there's no life? I'm hearing 2deep4u 'philosophy' about the universe, nobody needs a condescending goofy sounding false prophet about how to think.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#72

Post by RobotToaster »

johnnyworker wrote: post #26

Sure, "the" elderly. Everyone who is suffering from aging will be helped. No special treatment for powerful people, it'll be all about "the elderly".

It is a concern, look at the current monoclonal antibody alzheimer's treatment that's insanely expensive.

Generally though it's in the interest of the rich to extend the useful lifespan of their workers, training workers from babies is expensive, so it could be cheaper to keep the current ones going for 200 years.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#73

Post by seydor »

graphe wrote: post #59
seydor wrote: post #56

Earlier quoted context omitted.

Why not? Why don't we give children the right to vote? (even if delegated to their parents - might help with failing demographics too). What is the rationale behind the current rules anyway

Until you give a good reason why, your idea is as thoughtful as the effort you put into it.

as stated, for equality reasons

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#74

Post by tambourine_man »

graphe wrote: post #51
kalium-xyz wrote: post #3

Earlier quoted context omitted.

Its further evidence for a hypothesis on the mechanism of aging. Personally I just wanna know how aging works

Don't your telomeres get shorter, your DNA gets damaged and it doesn't replicate correctly anymore? Some animals can be immortal like lobsters but face limits like their physical size can kill them when they molt enough.

I think the consensus is that it’s part of the process, but not the whole picture, but I’m no expert.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#75

Post by dghughes »

gumby wrote: post #23
block_dagger wrote: post #9

Earlier quoted context omitted.

My mother is going through a kind of hell created by laws that prevent her from ending her life as she wishes. I hope dignity around death for the elderly becomes more of a public issue.

My grandmother starved herself to death at 97 because any other approach was then illegal (for anyone else to facilitate). All her friends were dead and she didn’t really like old people. As her vision and hearing started to deteriorate she figured it was not worth waiting for a letter from the Queen.

Dad died in 2021 at age 78 he was sick for a long time and at lest he had the option of MAID (Medical assistance in dying). He went to palliative care and I think really that is what happened. He never said, the staff never said but they were constantly injecting him and he died in his sleep unaware.

My Mom is 79 and often says she doesn't know anyone when she goes out. Her eyesight and hearing are both poor but not to the point of not seeing or hearing at all. But she said in stores, church, anywhere she goes there is nobody she recognizes even older people. So if you make it to old age and are in good health not stuck in a home and are mobile and can converse with people it can be very lonely if you are not good at making friends at that stage of life.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#76

Post by graphe »

seydor wrote: post #73
graphe wrote: post #59

Earlier quoted context omitted.

Until you give a good reason why, your idea is as thoughtful as the effort you put into it.

as stated, for equality reasons

Equality is meaningless. Why should we not have the same amount of ears as noses? That is inequality. Why should we use one fork instead of two for equality of the use of our hands and symmetry? Why not our keyboards be mirrored and equal too?

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#77

Post by Torkel »

RobotToaster wrote: post #69
Torkel wrote: post #29

Earlier quoted context omitted.

"Remarkably, the microenvironmental change and the functional decline of mid-old cells could be reversed by a young cell-originated protein, SLIT2. Our data identify functional reversion of mid-old cells as a potential method to prevent or ameliorate aspects of aging-related tissue dysfunction." I think this sounds promising.

So, potentially, we can synthesise this SLIT2 and inject people with a bunch of it?

That is, unfortunately!, not how these things work. But it allows people to do more targeted studies, and (many years of research later) perhaps find a drug that can have some impact.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#78

Post by morbicer »

graphe wrote: post #71
morbicer wrote: post #70

Earlier quoted context omitted.

The whole universe runs on decay & arise of the new. From stars through chemical compounds through cells to us humans. If the rotating cloud of gas and dust stayed forever, there would be no Earth. If the chemical compounds would be super stable, there would be no life. And so on. Systems are kept in equilibrium by this, otherwise they became unstable. Making space for the next, better entity is a cosmological princi…

Carbon is very stable, so there's no life? I'm hearing 2deep4u 'philosophy' about the universe, nobody needs a condescending goofy sounding false prophet about how to think.

Carbon is created by nuclear fusion in stars. Thus, something has to perish for carbon to appear. Carbon is also mostly found as compounds in the universe, not as elemental form. Indeed, if carbon was stable as argon, there would be no life. Luckily it forms many volatile organic compounds which can be in an endless cycle of reorganizing.

It's not some deep philosophy, it's basic science.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#80

Post by [deleted] »

tgvaughan wrote: post #62

Aside: figure 1 epitomizes everything that I hate about high-impact results-first journals: everything has to be packed into this one figure because nobody's expected to read anything else. No disrespect to the authors, these journals force you to express your work in this reader-hostile fashion where the most important parts of the paper wind up buried in the supplement.

[deleted]
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