I found in college that lack of sleep significantly reduced my anxious and depressive thoughts, but it also reduced my ability to think deeply about things, I think it was sort of a less thinking has both negative and positive side effects type of thing
One sleepless night can rapidly reverse depression for several days in mice
281–290 of 312 posts
Re: One sleepless night can rapidly reverse depression for several days in mice
#282Earlier quoted context omitted.
I tried this once, Family Doctor actually ended up giving me a dose that was twice the maximum anyone is ever supposed to take. Thankfully the Pharmacist told me that was an extremely bad idea and he just gave me my normal dose and I continued on for a bit. After that was when I ended up cold turkey because I lost my doctor and psychiatrists during a big move and couldn't get a refill at any clinic in the new town. I…
Those drugs you used contains benzodiazepine [1]. It's addictive and if used long, do more harm than helping. I'm glad you get rid of it. [1] https://en.m.wikipedia.org/wiki/Benzodiazepine
Why would you think they're taking benzos on a thread about SSRIs?
Re: One sleepless night can rapidly reverse depression for several days in mice
#283Earlier quoted context omitted.
I've bought CBD distillate and augmented regular tincture provided by a friend. I used to smoke a lot of weed and can no longer do so (lungs and head have had enough). For actual "head space" it's hard to beat inhaling but one must do what the body needs... I saw your other comment and am intrigued. What do you use to extract with? Ethanol? Glycerine? Link to the tek? As to your other comment about pharma -- I'm a be…
I don't have a link to a tek, as I've combined my findings to make the best quality oil with my current understanding and available technology. It's evolved over the batches and is pretty good I think now. Though you could find something similar on the internet. It does use food grade grain alcohol, close to ethanol. I start by grinding the flower to small pieces, or use shake which is significantly less expensive an…
Thanks for sharing. My only comment is that if extraction is your goal, putting it in the freezer will not necessarily help you there. If you see less chlorophyll being extracted that way, it likely means lies off the other stuff as well. It may be the case that the loss is negligible though.
Re: One sleepless night can rapidly reverse depression for several days in mice
#284Earlier quoted context omitted.
I don't have a link to a tek, as I've combined my findings to make the best quality oil with my current understanding and available technology. It's evolved over the batches and is pretty good I think now. Though you could find something similar on the internet. It does use food grade grain alcohol, close to ethanol. I start by grinding the flower to small pieces, or use shake which is significantly less expensive an…
Thanks for sharing. My only comment is that if extraction is your goal, putting it in the freezer will not necessarily help you there. If you see less chlorophyll being extracted that way, it likely means lies off the other stuff as well. It may be the case that the loss is negligible though.
Freezing bursts cell walls and makes trichromes more weakly attached. This in theory increases ease of entering solution? Thanks to GP for the write-up!
Re: One sleepless night can rapidly reverse depression for several days in mice
#285Earlier quoted context omitted.
> any chemical that helps you sleep ensures that you can't sleep without it Except melatonin, because that's what your body natural produces as a signal for sleep.
I’m getting a kick out of how this is the same “because” for every drug that becomes a dependency for the exact same reason
Not really. Melatonin has decades of long-term studies behind it, no serious issues. The biggest problems are dosing. Many supplements include way too much.
Re: One sleepless night can rapidly reverse depression for several days in mice
#286Earlier quoted context omitted.
I tried this once, Family Doctor actually ended up giving me a dose that was twice the maximum anyone is ever supposed to take. Thankfully the Pharmacist told me that was an extremely bad idea and he just gave me my normal dose and I continued on for a bit. After that was when I ended up cold turkey because I lost my doctor and psychiatrists during a big move and couldn't get a refill at any clinic in the new town. I…
Those drugs you used contains benzodiazepine [1]. It's addictive and if used long, do more harm than helping. I'm glad you get rid of it. [1] https://en.m.wikipedia.org/wiki/Benzodiazepine
Benzos and SSRIs are different things. The former is a CNS depressant that acts instantly. The latter builds up in your system over a month to increase the seretonin levels in your brain. They’re not really related except that someone with, e.g., anxiety might be prescribed both
Re: One sleepless night can rapidly reverse depression for several days in mice
#287Earlier quoted context omitted.
I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous. After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife. Rebound depression have been an issue - though in general…
Just a side note for anyone reading: you can get an SSRI prescription from your GP (general practitioner i.e. normal doctor) you don’t need to go through a psychiatrist. This is especially true if you are at risk for withdrawal, they will want to prevent that.
My pharmacist can even prescribe a month’s supply if I’m running out. Stopping an SSRI cold turkey is a really bad idea.
Re: One sleepless night can rapidly reverse depression for several days in mice
#288Serotonin is overrated, SSRI's and weed create unmotivated, pliable people. It is the hormone of bears going into hibernation. That's partly why it'll make you a sexless individual...
One theory about the beneficial impacts of psychedelic is that they have such power affinity for serotonin receptors that the body downregulates their expression as a result. However, this effect did not bear causative fruit in a swim-stress coping experiment with mice [1].
Re: One sleepless night can rapidly reverse depression for several days in mice
#289Earlier quoted context omitted.
Not to be flippant, but that’s called sleep deprivation. I did this daily for 18-24mo straight, sleeping a 3h block early morning (~4:30-7:30) and a 27min nap aligned with my sleep/wake cycle during mid-afternoon. I did this without caffeine, stimulants, sugar, etc. After having more kids I couldn’t keep the daily consistency required and scaled back to 1-3x a week. I spent years convinced that it elevated my coding,…
Its def not a lifestyle, I don't feel like I made that super obvious. I'm talking about a once in a blue moon type deal where you need a hard reset. Sorta like how most people rarely turn off their phones, things get fucky with it eventually, and it needs a hard reset or reboot. Don't get too hung up on the metaphors, but I've experienced it working and I'm not exactly an n=1
Its more like stochastic sleep deprivation without the randomness.
Re: One sleepless night can rapidly reverse depression for several days in mice
#290Earlier quoted context omitted.
My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.
I had a period when I used THC (edibles) for sleep every night. This was one of the worst things I have ever done to myself. At first, you don't notice much side effects, but slowly it creeps up on you. It makes you depressed, depletes of any motivation, gives brain fog and you may just feel weird over all. When I quit I was amazed by how much better I started feeling and by how much my cognitive function improved. I…
It is really hard to get people to understand that. And there is a lot of false beliefs about thc being safe and being overall good. Maybe in small occasional amount, but I keep seeing disasters around me with heavy consumers.