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One sleepless night can rapidly reverse depression for several days in mice

news.northwestern.edu

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Re: One sleepless night can rapidly reverse depression for several days in mice

#261

Post by lofaszvanitt »

Hard_Space wrote: post #35

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

Stop coffee/tea/other stimulants maybe, change eating habits maybe, fasting for 1-3 days, change start of sleep, observe the effect. Change one thing at a time.

Re: One sleepless night can rapidly reverse depression for several days in mice

#262

Post by isignal »

Timon3 wrote: post #135
Waterluvian wrote: post #79

Earlier quoted context omitted.

Yeah. I’ve tried. My problem is that 3-4 days of no sleep and I’m just about ready to sign off from this life. I’ve managed with 5mg THC pills for years. Never had to increase the dosage. I’ve never ever slept well. But back before kids it was easier to just sleep in if I had to. As best as I can tell, the cause is my adhd or related. My brain will simply. Not. Stop. Racing.

I used to have the same sleep problem (head won't stop racing), and mindfulness exercises throughout the day have greatly improved things for me. In a way it feels like the ability to turn it down for a time, long enough to get so tired it doesn't start back up again. One trick I found myself is to visualise things in the noise from your closed eyes. Try to interpret something you can vaguely see, and then try to vis…

Body scan meditation is one particular form of meditation that I’ve found effective for sleep.

Re: One sleepless night can rapidly reverse depression for several days in mice

#263

Post by Gud »

manquer wrote: post #231
Gud wrote: post #197

Earlier quoted context omitted.

Please don’t make such blanket statements. They can have many harmful side effects, including sexual dysfunction.

I think OP meant to say, these are not drugs is not something you can OD with easily and kill yourself, not that they are side effect free .

In many cases they have induced suicide. There are many ways something can be unsafe.

Re: One sleepless night can rapidly reverse depression for several days in mice

#266

Post by [deleted] »

Gud wrote: post #197
H8crilA wrote: post #144

Earlier quoted context omitted.

A lot of non-psychiatrist doctors prescribe SSRIs around the world, and that's a very good thing. These drugs are safe.

Please don’t make such blanket statements. They can have many harmful side effects, including sexual dysfunction.

[deleted]

Re: One sleepless night can rapidly reverse depression for several days in mice

#267

Post by codethief »

jamestimmins wrote: post #222
pedalpete wrote: post #168

The impact of sleep restriction on depression has been known for decades (though most of the research I'm seeing is from late 2010s on [1], this link says "from the beginning of the last century [2]) However, sleep deprivation as a treatment needs to be balanced with the health impact of sleep deprivation itself. A single night of lost sleep can have significantly detrimental impact on long-term health. Insulin respo…

Ironically, I've had several bouts of depression kicked off by pulling an all-nighter.

Exactly, sleep deprivation can also cause a loss in willpower and thus move oneself closer to the depression/apathy end of the spectrum. Nothing new, really, but as it so happens I listened to Andrew Huberman's podcast on "willpower & tenacity" last night where he spends a good amount of time addressing this topic.

Re: One sleepless night can rapidly reverse depression for several days in mice

#268

Post by codethief »

ngngngng wrote: post #101
not-my-account wrote: post #3

Queue people blogging about their monthly “sleep fast” for optimized mood and focus.

That's exactly where my brain went. Now I need a Huberman Labs podcast telling me how I can incorporate this with my supplements and cold showers to achieve my maximum potential.

I know you're joking but I'm seriously wondering how the OP fits the research Huberman regularly cites (sleep is good for dopamine levels, willpower etc.)

Re: One sleepless night can rapidly reverse depression for several days in mice

#269

Post by piuantiderp »

biohacker85 wrote: post #233
thowaway91234 wrote: post #93

Earlier quoted context omitted.

I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous. After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife. Rebound depression have been an issue - though in general…

Sometimes I wish I wasn't so cynical, but I've suspected that SSRIs are a preferred treatment because it is almost impossible to get off of them. They say "It can take up to a month for it to work" is just a way to make sure dependency is strong enough by that point to make withdrawal unbearable. Many people don't fully understand the concept of withdrawal or chemical dependency, and will think the "medicine" works b…

You just discovered most prescriptions in the US. Big example, insulin, once you take it, ooof, never going back...
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