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One sleepless night can rapidly reverse depression for several days in mice

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Re: One sleepless night can rapidly reverse depression for several days in mice

#81

Post by hotpotamus »

Loughla wrote: post #60
Waterluvian wrote: post #45

Earlier quoted context omitted.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

So I feel like you exactly identified the long term problem in the same paragraph. I learned years ago that any chemical that helps you sleep ensures that you can't sleep without it. I've used everything from thc to Benadryl to lavender and everything in between. It all had the same effects: slowly degrading effectiveness and sleeplessness without it. Pro-tip: find the source of your insomnia. Is it chemical or is it…

Getting to the source certainly sounds ideal, but I wonder - if you find a variety of substances help though develop tolerance, couldn't you rotate them to try and keep them effective?

Re: One sleepless night can rapidly reverse depression for several days in mice

#82

Post by lucia-goldsmith »

IntrepidPig wrote: post #65
lucia-goldsmith wrote: post #53

The article "One Sleepless Night Can Rapidly Reverse Depression for Several Days" is a fascinating and promising piece of research. The findings suggest that sleep loss could be a potential treatment for depression, which is a debilitating condition that affects millions of people worldwide. I am particularly interested in the implications of this research for many people. I believe that this research could lead to n…

Was this written by an LLM?

No, it was not written by a language model (LLM). I know one of the authors, Mingzheng Wu, and have followed his work closely, including his papers on the rapid enhancement of glutamate-evoked dendritic spinogenesis in the medial prefrontal cortex through dopaminergic mechanisms, and the suppression of neuropathic pain through inhibition of YAP/TAZ activity in the spinal cord.

Re: One sleepless night can rapidly reverse depression for several days in mice

#84

Post by manmal »

Waterluvian wrote: post #45
Hard_Space wrote: post #35

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

Tapering off very slowly (over weeks or months) will probably work better than cold turkey.

Re: One sleepless night can rapidly reverse depression for several days in mice

#86

Post by coldtea »

shtopointo wrote: post #13

What about all the other studies claiming that poor sleep causes depression? Not sure what to trust these days. Gut tells me poor sleep won't make you ahem "your brain feel slap-happy, loopy and almost giddy" (very scientific).

>What about all the other studies claiming that poor sleep causes depression?

What about them?

This is about one sleepless night every several days/week for an already depressed person.

Not about non-depressed people continuously sleeping poorly (which is where poor sleep would cause depression).

Re: One sleepless night can rapidly reverse depression for several days in mice

#87

Post by LesZedCB »

hshsbs84848 wrote: post #67
throwaway4837 wrote: post #31

Waking up in the mornings helps reset my mental state sometimes. I wonder if it's related. If I have an early morning, I usually find that I'm more productive and have more energy to work out or focus on tasks. There's nothing more depressing than a cycle of waking up at 2pm because you stayed up until 5am. Waking up so late makes me feel like I'm wasting my life.

I’ve found that too Somehow I feel really energized if I wake up like 2-3 hours before my regular time But only if I haven’t done it in a while Something about disrupting the pattern seems to throw off the usual morning grogginess

it's my favorite part about early morning flights. i don't fly often, but when i do travel the following two weeks where i practically jump out of bed at 6-7am are amazing.

Re: One sleepless night can rapidly reverse depression for several days in mice

#90

Post by nwienert »

Waterluvian wrote: post #45
Hard_Space wrote: post #35

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

If you can, try Semaglutide.

I am a top % light sleeper - hard to sleep, inconsistent, never could sleep outside of basically ideal conditions.

Was prescribed Tirzepatide (similar to Semaglutide) and it fixed my sleep like nothing else has - I actually feel tired at a normal hour and doze off, two thing I never really did before. At the lowest dose you won't lose weight beyond the first few months, and you can maintain weight with small effort even still. So even if you are completely healthy weight, it could be useful.

I wouldn't normally think recommending a totally unrelated drug for sleep issues would be sane, but it also happens to have a ton of other positive effects for me at least. And the safety profile seems solid, esp compared to other sleep drugs. Plus not psychoactive and actually reduces your addictive behaviors especially in terms of nicotine/THC. Certainly a lot better side effect profile than THC (imo, from research).

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