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Study shows antibodies against PEG in 83% of the German population

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Re: Study shows antibodies against PEG in 83% of the German population

#131
post #57

Earlier quoted context omitted.

Just speaking from personal experience, I’m fat because I eat cake and ice cream every day and walk 6,000 steps on a good day. I don’t really see a mystery here tbh.

Sure, but something has made far more people make choices like yours than ever used to. We don't yet know what that is. We probably should. Our individual choices are ours to make, but they don't happen in a vacuum. Cultural signals, environmental factors, biological processes, uncritically reinforced habits, etc all shape what choices we're inclined towards and what choices look implausible or untenable. There's bee…

> Sure, but something has made far more people make choices like yours than ever used to.

Not a big mystery there. Food used to be expensive and cakes only available in special occasions. Now I can get a cake delivered to my home within half an hour without getting up from my chair and it costs me about 15 minutes worth of paid work.

Re: Study shows antibodies against PEG in 83% of the German population

#132
post #119

Earlier quoted context omitted.

Having seen now 3 people die of colon cancer in their early 30s, I can see why early and frequent detection makes sense.

Damn... see any patterns, in lifestyle, diet etc?

All women, 2 had a child less than 2 years old. Two very healthy in diet exercise, one average health

Re: Study shows antibodies against PEG in 83% of the German population

#133
post #39
post #30

Earlier quoted context omitted.

olive oil has been widely available for the last 7000 years, butter for ten thousand years, but the obesity pandemic is only 50 years old

Both of those until very recently were extremely expensive to the point of luxury for many, as well as much more difficult to effectively use a lot of cheap and easily. Effectively zero people are chugging bottles of Olive Oil they buy from the corner store. There just is no comparison whatsoever to modern processed foods set for immediate consumption and tuned for maximum taste and pleasure response. Edit: to refute…

> Even my grandparents saw things like olive oil and real butter as luxury items.

That "real" is doing a lot of heavy lifting.

Re: Study shows antibodies against PEG in 83% of the German population

#134

Footnote: PEG = polyethylene glycol in this context. So the study is related with people developing allergy to cosmetics and industrial products.

It's also the primary allergen contained within the MRNA COVID-19 vaccines AIUI.

Re: Study shows antibodies against PEG in 83% of the German population

#135
post #105

Earlier quoted context omitted.

False equivalence. This doesn't help advance the debate. The amount of olive oil in the average diet is minuscule relative to the amounts of sugar or palm oil. Nuance is important.

it helps advance the debate by conclusively showing that caloric density is not the only relevant factor, or even a dominating one, and that in fact nuance is important, which is my point there are lots of simple, well-known explanations, and they are all wrong. that was one of them. 'it's sugar' and 'it's hfcs' are two others that have popped up in this thread

I get your point but olive oil is nowhere near as prevalent as sugar. Some products even market themselves as "premium" for containing olive oil.

Re: Study shows antibodies against PEG in 83% of the German population

#136
post #19

i guess they'll just have to use lalr(1) more seriously, i wonder if something like this is a cause of the obesity pandemic: an unrecognized widespread immune response to a novel food additive provoking continuous low-level inflammation though probably not peg itself; e1521 is not in that many foods, not like xanthan gum or nanoparticles of titanium dioxide

How would that explain the massive difference in obesity rates between countries?

Re: Study shows antibodies against PEG in 83% of the German population

#137

Earlier quoted context omitted.

> Culture has simply changed, and (bad) food has gotten to be incredibly cheap and easy to access. It’s Gresham’s “law”: “bad money drives out good”, but applied to food. https://en.m.wikipedia.org/wiki/Gresham's_law

It's also the simple fact that the average blue collar worker hasn't seen rising wages since the 80s. All the money accrued to the top, and the workers were left trying to make the same value of take home pay stretch farther and farther. The reason most people think inflation sucks is because modern society would rather collapse than pay workers in line with historical norms.

>It's also the simple fact that the average blue collar worker hasn't seen rising wages since the 80s.

You probably need to define what you mean by average blue collar worker as there are many ways of looking at this data (and it is often difficult to even find the estimated levels of transfer payments being given). For example, this Fed chart shows CPI adjusted median household income rising from around 57 thousand to around 75 thousand today: https://fred.stlouisfed.org/series/MEHOINUSA672N

Re: Study shows antibodies against PEG in 83% of the German population

#138

Earlier quoted context omitted.

> Culture has simply changed, and (bad) food has gotten to be incredibly cheap and easy to access. It’s Gresham’s “law”: “bad money drives out good”, but applied to food. https://en.m.wikipedia.org/wiki/Gresham's_law

It's also the simple fact that the average blue collar worker hasn't seen rising wages since the 80s. All the money accrued to the top, and the workers were left trying to make the same value of take home pay stretch farther and farther. The reason most people think inflation sucks is because modern society would rather collapse than pay workers in line with historical norms.

Every real wage chart I see looks like workers have made slight but reasonably steady improvements since 2000 and are 10-15% ahead of the 1980s.

https://fred.stlouisfed.org/series/LES1252881600Q

Re: Study shows antibodies against PEG in 83% of the German population

#139
post #71

Earlier quoted context omitted.

There are two considerable points here: 1) this is a simple molecule, not an organism that can react to the threat. As you said, it would be interesting to be evaluate whether the antibodies actually have an effect, but they probably have, else they likely wouldn't have been detected at all. 2) the blood samples were taken from patients. It would be interesting to evaluate blood samples from the population at large.

To point (1), antibodies against non-alive substances are how you get things like allergies and autoimmune diseases. Your body goes "holy shit pollen!" and makes you break out in hives or "holy shit gluten!" and makes your guts inflamed. Not all the time, obviously, and it depends on the type of antibody.

This comment is "not even wrong".

I'm not sure how much more "alive" you expect something like pollen to be (or most allergens, which are usually proteins or protein fragments). Nobody is claiming that antibodies are binding to whole-cats or whole-dogs. They normally bind to protein, and sometimes to protein-coupled-with-small-molecules.

It's fairly notable for there to be Abs against synthetic molecules, even if PEG is technically organic, and a relatively large molecule.

Re: Study shows antibodies against PEG in 83% of the German population

#140
post #71

Earlier quoted context omitted.

There are two considerable points here: 1) this is a simple molecule, not an organism that can react to the threat. As you said, it would be interesting to be evaluate whether the antibodies actually have an effect, but they probably have, else they likely wouldn't have been detected at all. 2) the blood samples were taken from patients. It would be interesting to evaluate blood samples from the population at large.

> As you said, it would be interesting to be evaluate whether the antibodies actually have an effect, The article has a quote from the researchers about how the antibodies could remove a future PEG nanocarrier from the patients' system: > "The antibodies formed against PEG attach themselves to the coated nanocarriers, thus counteracting the effect that is actually desired: the nanocarrier becomes visible to the immun…

PEG is used in so many biomedical applications, largely because of its favourable immunochemical properties-- that's precisely the concern.
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