Earlier quoted context omitted.
Unfortunately not really, because the infrastructure that allows us to glean insights from actual healthcare practices is abysmal/nonexistent, at least in the US. It became clear during COVID that a lot of people seem to presume there's some way for researchers to just "look at what's happening," and there isn't.
There's no nationwide research infrastructure for gleaning insights like that. But large provider organizations have huge patient populations and do a lot of research. They have multiple studies underway for Ozempic and similar drugs.
Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
51–60 of 89 posts
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#52Earlier quoted context omitted.
I wish more folks would get comfortable crushing tablets and weighing out their own dosage on scales. It’s not that hard to cut tabs in half or crush two and make 3 doses out of those, then put them back into caps. Empty gelatin caps are cheap and easy to work with. Should anyone have to do this? Of course not, but if the choice is between this or projectile vomit every waking hour, it’s not a hard choice IMO. Lastly…
I agree with your general point, although (and it may not be the same everywhere, but is certainly true in the UK) Ozempic is supplied as a pre-filled pen injector that handles the dose for you, and is taken once a week - there are no markings for a half-dose (and the patient info sheet seems to suggest that a partial dose isn't possible)
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#53"Another issue he brought up with the study is that the researchers found that people on Ozempic were five times more likely to drink alcohol compared to the other medications." Hm. May have located the problem. This is considered to be the first generation of weight loss drugs that work. There will probably be better ones.
So I think "other medications" is doing a lot of heavy lifting here. It depends on what medications they're talking about. I think since incretin mimetics are more "social" medications and taken usually by a younger crowd, it would make sense that more people are drinking than maybe other groups.
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#54I was gaining a lot of weight and simply walking for 30min was exercise (which sounds embarrassing in retrospect as I type it). So I did that daily around the neighborhood. That got easier, all I cared about was doing it daily not the outcomes, then I started going on a bike rides with slow increasing intensity, then got a gym membership, and now 2yrs later I’m in excellent shape, addicted to the feeling after working out, and do ~45min of fitness 5 days a week.
I know binge eating seems to be the issue with this one in particular but for me I naturally started to eat better on days I do fitness, I feel like eating things that give me energy. My body demands it. When I had relapses into not doing daily fitness I almost always eat poorly in a negative cycle just sitting on the couch drinking alcohol because I don’t have energy to go out.
Not to get preachy (everyone has a solution) but I think too many people do dramatic gym efforts or massively change diet with Keto (or w/e) then burn out quickly instead of starting small and focusing on routine/habit as the goal #1… not obsessing about how much calorie burn you can pack into x minutes before going back to nothing in 2 months. Fitness is a basic lifestyle routine like showering and brushing your teeth, it’s not a huge hard commitment when it’s paced properly and a natural daily thing.
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#55Is this sort of thing higher the longer you use it? If it’s only for 3-6 months to get the ball rolling and getting you walking and eventually into a gym it’s probably worth the risk. It really shouldn’t be a long term thing should it? I was gaining a lot of weight and simply walking for 30min was exercise (which sounds embarrassing in retrospect as I type it). So I did that daily around the neighborhood. That got ea…
I don’t think it has anything to do with whether people do a massive change or not. I think the people that enjoy exercise usually never have to do a massive change because they are already doing it from natural enjoyment.
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#56Anecdotal sample of one here: since starting the treatment a year ago, I have hardly set foot in a fast food restaurant, and my visits to other food establishments have been reduced by 75% at minimum. Grocery shopping has been more mindful and smaller in size. The impact on my desire or even ability to consume food beyond the base metabolic necessity is real.
Out of curiosity, do you also drink Yakult or similar? https://en.wikipedia.org/wiki/Yakult
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#57Can we just let people be fat and happy
It kind of really puts a load on the healthcare system and makes everyone’s rates go up. Plus it’s terrible for the individual themselves. Societal pressure is a fantastic motivator.
Fat shaming doesn't help anyone lose weight, it just makes you feel superior.
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#58Earlier quoted context omitted.
I agree with your general point, although (and it may not be the same everywhere, but is certainly true in the UK) Ozempic is supplied as a pre-filled pen injector that handles the dose for you, and is taken once a week - there are no markings for a half-dose (and the patient info sheet seems to suggest that a partial dose isn't possible)
Having taken it, I can say that attempting a half-dose of Wegovy pens would have wildly varying results. The smaller Ozempic pens can easily titrate down, but Wegovy pens are not at all designed for it.
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#59I don't know to what extent this kind of perspective matters compared to the obviously more common usage of obese people with serious diet control problems, but I come at this more from a physique sport angle. I have no real interest in getting big and don't want to use steroids, so I don't actually compete, but I do lift nearly every day, run nearly every day, and have become extremely lean, probably currently somew…
If it was available readily and cheap, I'd be curious to give it a try, though I have no desire to ever get below 10% body fat.
Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study
#60Anecdotal sample of one here: since starting the treatment a year ago, I have hardly set foot in a fast food restaurant, and my visits to other food establishments have been reduced by 75% at minimum. Grocery shopping has been more mindful and smaller in size. The impact on my desire or even ability to consume food beyond the base metabolic necessity is real.
Why is that? For me, it was because I'd get severe symptoms after eating fatty foods.