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Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

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Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#51
post #37

Earlier quoted context omitted.

Unfortunately not really, because the infrastructure that allows us to glean insights from actual healthcare practices is abysmal/nonexistent, at least in the US. It became clear during COVID that a lot of people seem to presume there's some way for researchers to just "look at what's happening," and there isn't.

There's no nationwide research infrastructure for gleaning insights like that. But large provider organizations have huge patient populations and do a lot of research. They have multiple studies underway for Ozempic and similar drugs.

Totally. I didn’t say “it won’t be studied,” I’m saying the data won’t be “great,” as described above.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#52

Earlier quoted context omitted.

I wish more folks would get comfortable crushing tablets and weighing out their own dosage on scales. It’s not that hard to cut tabs in half or crush two and make 3 doses out of those, then put them back into caps. Empty gelatin caps are cheap and easy to work with. Should anyone have to do this? Of course not, but if the choice is between this or projectile vomit every waking hour, it’s not a hard choice IMO. Lastly…

I agree with your general point, although (and it may not be the same everywhere, but is certainly true in the UK) Ozempic is supplied as a pre-filled pen injector that handles the dose for you, and is taken once a week - there are no markings for a half-dose (and the patient info sheet seems to suggest that a partial dose isn't possible)

Having taken it, I can say that attempting a half-dose of Wegovy pens would have wildly varying results. The smaller Ozempic pens can easily titrate down, but Wegovy pens are not at all designed for it.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#53
post #34

"Another issue he brought up with the study is that the researchers found that people on Ozempic were five times more likely to drink alcohol compared to the other medications." Hm. May have located the problem. This is considered to be the first generation of weight loss drugs that work. There will probably be better ones.

What's odd is that a common side effect with semaglutide medications is a severe reaction to alcohol. Anecdotally, I vomit any time I have alcohol in beer sized doses. In fact, semaglutide is being investigated as a potential treatment for Alcoholism. (https://www.npr.org/sections/health-shots/2023/08/28/1194526...)

So I think "other medications" is doing a lot of heavy lifting here. It depends on what medications they're talking about. I think since incretin mimetics are more "social" medications and taken usually by a younger crowd, it would make sense that more people are drinking than maybe other groups.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#54
Is this sort of thing higher the longer you use it? If it’s only for 3-6 months to get the ball rolling and getting you walking and eventually into a gym it’s probably worth the risk. It really shouldn’t be a long term thing should it?

I was gaining a lot of weight and simply walking for 30min was exercise (which sounds embarrassing in retrospect as I type it). So I did that daily around the neighborhood. That got easier, all I cared about was doing it daily not the outcomes, then I started going on a bike rides with slow increasing intensity, then got a gym membership, and now 2yrs later I’m in excellent shape, addicted to the feeling after working out, and do ~45min of fitness 5 days a week.

I know binge eating seems to be the issue with this one in particular but for me I naturally started to eat better on days I do fitness, I feel like eating things that give me energy. My body demands it. When I had relapses into not doing daily fitness I almost always eat poorly in a negative cycle just sitting on the couch drinking alcohol because I don’t have energy to go out.

Not to get preachy (everyone has a solution) but I think too many people do dramatic gym efforts or massively change diet with Keto (or w/e) then burn out quickly instead of starting small and focusing on routine/habit as the goal #1… not obsessing about how much calorie burn you can pack into x minutes before going back to nothing in 2 months. Fitness is a basic lifestyle routine like showering and brushing your teeth, it’s not a huge hard commitment when it’s paced properly and a natural daily thing.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#55
post #54

Is this sort of thing higher the longer you use it? If it’s only for 3-6 months to get the ball rolling and getting you walking and eventually into a gym it’s probably worth the risk. It really shouldn’t be a long term thing should it? I was gaining a lot of weight and simply walking for 30min was exercise (which sounds embarrassing in retrospect as I type it). So I did that daily around the neighborhood. That got ea…

I think people vary greatly in how much they enjoy exercise. I don’t, unfortunately, so it’s very hard for me to keep up any aerobic exercise program. I simply don’t form a habit, I have to push myself every time.

I don’t think it has anything to do with whether people do a massive change or not. I think the people that enjoy exercise usually never have to do a massive change because they are already doing it from natural enjoyment.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#56

Anecdotal sample of one here: since starting the treatment a year ago, I have hardly set foot in a fast food restaurant, and my visits to other food establishments have been reduced by 75% at minimum. Grocery shopping has been more mindful and smaller in size. The impact on my desire or even ability to consume food beyond the base metabolic necessity is real.

Out of curiosity, do you also drink Yakult or similar? https://en.wikipedia.org/wiki/Yakult

may i ask why?

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#57
post #5

Can we just let people be fat and happy

It kind of really puts a load on the healthcare system and makes everyone’s rates go up. Plus it’s terrible for the individual themselves. Societal pressure is a fantastic motivator.

Shame is a terrible motivator for weight loss. It just doesn't really work. Nobody gets fat because they think being fat is okay. Fat people tend to be struggling with other things that they largely need to tackle before they have the emotional bandwidth to do the un-fat thing.

Fat shaming doesn't help anyone lose weight, it just makes you feel superior.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#58
post #52

Earlier quoted context omitted.

I agree with your general point, although (and it may not be the same everywhere, but is certainly true in the UK) Ozempic is supplied as a pre-filled pen injector that handles the dose for you, and is taken once a week - there are no markings for a half-dose (and the patient info sheet seems to suggest that a partial dose isn't possible)

Having taken it, I can say that attempting a half-dose of Wegovy pens would have wildly varying results. The smaller Ozempic pens can easily titrate down, but Wegovy pens are not at all designed for it.

Yup, and this is mostly to protect profit for the pharma companies so people don't split doses.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#59

I don't know to what extent this kind of perspective matters compared to the obviously more common usage of obese people with serious diet control problems, but I come at this more from a physique sport angle. I have no real interest in getting big and don't want to use steroids, so I don't actually compete, but I do lift nearly every day, run nearly every day, and have become extremely lean, probably currently somew…

I'd guess there are a few factors at play, but my assumption is that the drug is perceived as a cheat. We see obese people as weak and loathsome due to their own failings and now they're going to simply take a drug and think they can get away with it? Surely they must deserve some punishment. Surely this drug is too good to be true.

If it was available readily and cheap, I'd be curious to give it a try, though I have no desire to ever get below 10% body fat.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#60
post #20

Anecdotal sample of one here: since starting the treatment a year ago, I have hardly set foot in a fast food restaurant, and my visits to other food establishments have been reduced by 75% at minimum. Grocery shopping has been more mindful and smaller in size. The impact on my desire or even ability to consume food beyond the base metabolic necessity is real.

Why is that? For me, it was because I'd get severe symptoms after eating fatty foods.

Semaglutide made me feel more like I was full and simultaneously made me feel less like I was hungry. The stomach slowdown helped as well. I had some of the less desirable side effects of that, and those were really unpleasant but also showed me that I had no real idea when I was full or hungry and wasn’t eating for the right reasons. I’m hoping the insight sticks, at least.
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