It's plausible, even probable, given the arguments layed out in Nick Bolstrom essay "Are you living in a computer simulation?".
I used to think the question that should preclude this one is if the universe is even able to host a simulation of itself, but given that we know it is probable we live in a perceived reality that not only is separated from what we think as objective reality, that this perceived reality is, for the sake of survival, a much simplified version of the objective reality, then it isn't impossible that a base objective reality might harbor countless simulations not unlike the one we possibly live in.
This is however an interesting experiment in a way to guide moral decisions when we encounter technological leaps, like if we ever develop the capability of producing an ASI. I don't think, however, that these considerations are falsifiable, because we can't just "break out" of our possible simulation to see what is what. What might that even mean? Would we be able to tell if we broke out of our simulation? It breeds all sorts of speculations that at the end of the day adds very little to the overall discussion.
What I personally think is that there is something to be perceived and explored ousite of the realm of human concern, in the silence of the absence of the endless chatter of the cognitive consciousness, that is hard to experience and hard to describe, even though it is accessible to everyone, maybe in the form of a question, like "what is really keeping you from experiencing the dharma body of the Buddha?".
I know this is all really esoteric and mystic, but I am really trying very hard to maintain a certain level of philosophical scrutiny here, if only whoever reads this might give me the benefit of the doubt. All in all this is my take on the subject and I hope I don't disappoint you too deeply.