81–90 of 195 posts
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> seemingly because politicians don't want to admit they fucked up How did politicians fuck up?
Probably GP meant they fucked up by downplaying the danger's of COVID and doing the least possible to keep the hospitals from overflowing. Where, instead, they should have done more to prevent people from getting COVID.
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> seemingly because politicians don't want to admit they fucked up How did politicians fuck up?
On ME/CFS they failed to fund any research for 70 years, on many occasions saying things that led to patients being abused and not believed by their families or doctors. This led to an attitude in the NIH that it wasn't worth funding research which persists still to this day. There has been no real funding for research out of the NIH since a brief spurt in the 1980s, even now what funding its allocated has mostly end…
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Sometimes it is exactly what they're doing. 15 years ago, shortly after surgery to remove a tumor from my femur, I ran into a physical therapy assistant whom I'd been working with when my doctors thought my leg pain was a soft tissue problem. He said he'd heard about my surgery and was glad I was doing well, and then as we parted ways he cheerfully commented offhand that when I'd been working with him and his supervi…
Statistically speaking, you were making that all up. Of course in your case it turned out to be serious, but think about how negligible the odds of that are when you're seeing dozens of patients a day during your career.
There is some research currently on low doses of naloxone as a treatment for long Covid/CFS/ME. Would naloxone have anything to do with this protein, or is it an unrelated approach?
There could be a link here, although it is tenuous and purely lay speculation. ER stress is discussed in the article:
>Both S1 and the people with ME/CFS had biochemical signatures of ER stress in their muscles, and treating S1’s cells in a dish with a drug that blocks ER stress lowered WASF3 levels and restored mitochondrial function. On the flipside, using toxins to artificially induce ER stress in cultured cells or in mice caused a rise in WASF3 levels, Hwang says.
LDN has been found to be quite effective in alleviating ER stress specifically in the epithelial barrier in IBD [0], rather than the ER stress - WASF3 levels being investigated in muscle cells in the above article. Certainly worth investigating. And, as noted in the article, the WASF3 angle is merely one potential pathway of the disorder.
[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845217/
>Low dose Naltrexone induced clinical improvement in 74.5%, and remission in 25.5% of patients. Naltrexone improved wound healing and reduced ER stress induced by Tunicamycin, lipopolysaccharide or bacteria in epithelial barriers.
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I am not buying that psychiatry actually helped. With this type of condition, some people get better over time. So those people would have gotten better anyway without the psychiatry. I also think the medical community should also rethink the notion some symptoms are psychosomatic. Why is that true? Because doctors can't spot the cause, so it must be psychosomatic? Maybe the cause is there but undetectable or not und…
A a few weeks after I had COVID I started having panic attacks. I went up a couple of flights of stairs at work and felt immensely exhausted - way more than I should have, I use the stairs at work all the time. I started feeling like there might be something wrong with me and that turned into a panic attack. (Later, of course, that turned out to be a symptom of long COVID fatigue.) I was 32 at the time. Never had a p…
After getting COVID, I went from being an avid coffee connoisseur to getting extreme anxiety from a cup (I've never had anxiety either). I switched to decaf for 2 years before finally incrementally building my tolerance back up. Several colleagues and random people I've met have had similar issues. It goes away over time, but is very real.
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Statistically speaking, you were making that all up. Of course in your case it turned out to be serious, but think about how negligible the odds of that are when you're seeing dozens of patients a day during your career.
Why would any of those patients make up being in pain, let alone... most of them?
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> seemingly because politicians don't want to admit they fucked up How did politicians fuck up?
On ME/CFS they failed to fund any research for 70 years, on many occasions saying things that led to patients being abused and not believed by their families or doctors. This led to an attitude in the NIH that it wasn't worth funding research which persists still to this day. There has been no real funding for research out of the NIH since a brief spurt in the 1980s, even now what funding its allocated has mostly end…
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> doctors dismiss patients as crazy or "making it up" It's very easy to frame what doctors say like this, but in my experience at least that's not really what they're doing. A doctor is a classification machine - they take your symptoms as inputs and output a disease or a syndrome, hopefully with mitigation measures associated with it. When my wife had long covid for 3 years and doctors couldn't find anything wrong w…
The problem really is the stigma associated with mental illness as opposed to other kinds of illness. There are clearly mechanisms through which psychiatric effects manifest as real physical symptoms. If there's no obvious physiological cause to symptoms, working with it having a psychiatric basis seems perfectly reasonable. That doesn't mean we shouldn't try to understand more about it though.
You know, doctors told me for years that the pain in my chest and back was all because of my mental illness, even though my brother and mother both needed spinal surgery for Anklysoing Spondylitis by the time they were 60.
They dismissed me till I told them I wanted an MRI of my spine and chest and there it was, Non-radiographic axial spondyloarthritis, the precursor to AS. So not I can treat it so it does not process into AS. They all told me there was " physiological cause to symptoms".
There is a HUGE stigma in medicine against any pain in people with mental illness, it is their best excuse to not even look. That is why there is no progress.
Last Thursday the Dutch News reported about findings at Amsterdam UMC of an enzyme IDO-2 that keeps being produced in long covid patients' cells. And that an experimental cancer medicine manufactured by Bayer and BMS can put a stop to this. It was brought as an 'important step' in long covid research (that nonetheless would take years to lead to any broadly available cure). Unfortunately the article didn't publish li…
https://www.mdpi.com/ijms/ijms-22-11714/article_deploy/html/...
Iron deficiency has been a common feature of LC for a while:
https://timesofindia.indiatimes.com/life-style/health-fitnes...
There needs to be more research into this horrible disease. There are no yet confirmed biomarkers for it, so doctors dismiss patients as crazy or "making it up." Once there is a biomarker, perhaps like this protein, we can actually start testing treatments to see what works. The scary thing is that there seems to be a vicious path, of COVID->long COVID->ME/CFS. We're not sure what makes COVID evolve into long COVID,…
https://www.nih.gov/news-events/nih-research-matters/blood-t...
