A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
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Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#2> the onset of ME/CFS is often associated with viral infections by patients
I can personally attest to this. I was an extremely energetic person (shooting straight out of bed in the morning, never requiring daytime naps or rests) until one specific week in April of 1996 when I had what I thought was a mild flu. The post-flu fatigue never really went away. I became acclamatised to it over the years and rarely notice it now (except times like this when I'm reminded that I'm significantly less energetic than the average person). I hope they find a treatment (if not a cure) for this soon. As I understand, some suffers are not as lucky as I am.
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#3This is a finding more about cellular fatigue and might explain what fatigue actually is. The root cause of ME/CFS and Long Covid Fatigue is almost certainly a chronic infection in tissue without much detectable presence in fluids making it difficult to identify and treat.
It is an interesting finding since some treatments for ER stress exist and are worth testing. It's also somewhat linked to the Itaconate shunt theory that Robert Phair at Stanford has been investigating for the past year.
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#4Research paper on PNAS is paywalled. Article on science.org may be a better link:
https://www.science.org/content/article/protein-disrupts-cel...
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#5Last Thursday the Dutch News reported about findings at Amsterdam UMC of an enzyme IDO-2 that keeps being produced in long covid patients' cells. And that an experimental cancer medicine manufactured by Bayer and BMS can put a stop to this. It was brought as an 'important step' in long covid research (that nonetheless would take years to lead to any broadly available cure). Unfortunately the article didn't publish links to papers.
[0] In Dutch: https://nos.nl/artikel/2486149-experimenteel-kankermedicijn-...
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#6The WASF3 Protein shows up in other studies as well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703627/
I'm esp. interested in any interaction with food. Because I get depression 4 days after I ate a food. I don't have any other symptoms than low energy and a sense of impending doom. Symptoms stay for 3 days then go away. Started collecting the info in my github. I'm very interested if anyone has more ideas.
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#7How would one go about getting a test of the levels of this protein?
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#8The WASF3 Protein shows up in other studies as well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703627/ I'm esp. interested in any interaction with food. Because I get depression 4 days after I ate a food. I don't have any other symptoms than low energy and a sense of impending doom. Symptoms stay for 3 days then go away. Started collecting the info in my github. I'm very interested if anyone has more ideas.
Did you purposely leave out what type of food or was that a typo? Because that would be an (the) interesting part of your experience!
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#9The WASF3 Protein shows up in other studies as well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703627/ I'm esp. interested in any interaction with food. Because I get depression 4 days after I ate a food. I don't have any other symptoms than low energy and a sense of impending doom. Symptoms stay for 3 days then go away. Started collecting the info in my github. I'm very interested if anyone has more ideas.
That could be some micro-allergy to that food (or one of its ingredients)?
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#10The WASF3 Protein shows up in other studies as well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703627/ I'm esp. interested in any interaction with food. Because I get depression 4 days after I ate a food. I don't have any other symptoms than low energy and a sense of impending doom. Symptoms stay for 3 days then go away. Started collecting the info in my github. I'm very interested if anyone has more ideas.
Did you try antihistamines? This could be some form of acquired allergy or auto-immune reaction.