Last Thursday the Dutch News reported about findings at Amsterdam UMC of an enzyme IDO-2 that keeps being produced in long covid patients' cells. And that an experimental cancer medicine manufactured by Bayer and BMS can put a stop to this. It was brought as an 'important step' in long covid research (that nonetheless would take years to lead to any broadly available cure). Unfortunately the article didn't publish li…
A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
11–20 of 195 posts
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#12This is a finding more about cellular fatigue and might explain what fatigue actually is. The root cause of ME/CFS and Long Covid Fatigue is almost certainly a chronic infection in tissue without much detectable presence in fluids making it difficult to identify and treat. It is an interesting finding since some treatments for ER stress exist and are worth testing. It's also somewhat linked to the Itaconate shunt the…
It's probably not COVID hiding in the tissues? I wonder whether injection of genes by the virii result in altered DNA producing broken proteins. Is 23andMe data of sufficient quality to test altered DNA?
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#13The WASF3 Protein shows up in other studies as well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703627/ I'm esp. interested in any interaction with food. Because I get depression 4 days after I ate a food. I don't have any other symptoms than low energy and a sense of impending doom. Symptoms stay for 3 days then go away. Started collecting the info in my github. I'm very interested if anyone has more ideas.
Some ideas:
- Gastroparesis
- Thiol intolerance (impaired sulfur metabolism) - could try molybdenum and maybe Boron supplementation (ask doctor if ok)
- High gut permeability („leaky gut“) -> undigested proteins enter blood stream -> autoimmunity (eg via viral mimicry; all kinds of viruses can do that, but COVID and EBV come to mind). Water fasting could help, maybe digestive enzymes
- Mechnical interaction, eg dysbiosis -> bloating -> cervical spine misalignment -> more bloating due to vagal nerve pinching (try massaging back of the neck vigorously to see if depression disappears for a while)
- Auto-brewery syndrome
All of those can be downstream issues of systemic issues, like hypothyroidism (which has been shown to be caused by microbiome metabolites; I wouldn’t just down the next best yogurt though, but look at studies around Bifidobacterium Longum, which looks promising; probably others too).
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#14There needs to be more research into this horrible disease. There are no yet confirmed biomarkers for it, so doctors dismiss patients as crazy or "making it up." Once there is a biomarker, perhaps like this protein, we can actually start testing treatments to see what works.
The scary thing is that there seems to be a vicious path, of COVID->long COVID->ME/CFS. We're not sure what makes COVID evolve into long COVID, which also means we have no idea how many people who catch COVID eventually wind up with long COVID or ME/CFS. And there is a total media blackout on the topic, seemingly because politicians don't want to admit they fucked up.
Hopefully once there is a way to verifiably test for it, a lot of things will change for the better.
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#15This is a finding more about cellular fatigue and might explain what fatigue actually is. The root cause of ME/CFS and Long Covid Fatigue is almost certainly a chronic infection in tissue without much detectable presence in fluids making it difficult to identify and treat. It is an interesting finding since some treatments for ER stress exist and are worth testing. It's also somewhat linked to the Itaconate shunt the…
One potential mechanism for fatigue:
* Virus' have a high failure rate - many infected cells never go on to multiply.
* However, those infected cells may also not still perform correctly.
* If you have a good chunk of your cells in your body no longer performing their function, yet not dying and making way for replacements either, everything isn't going to work as well.
That would explain why it is a wide range of viruses that can all cause fatigue symptoms, and also why parasitic and bacterial infections rarely cause the same.
Technical term: Virus-induced senescence
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#16This is a finding more about cellular fatigue and might explain what fatigue actually is. The root cause of ME/CFS and Long Covid Fatigue is almost certainly a chronic infection in tissue without much detectable presence in fluids making it difficult to identify and treat. It is an interesting finding since some treatments for ER stress exist and are worth testing. It's also somewhat linked to the Itaconate shunt the…
It's probably not COVID hiding in the tissues? I wonder whether injection of genes by the virii result in altered DNA producing broken proteins. Is 23andMe data of sufficient quality to test altered DNA?
23andme looks for specific single nucleotide polymorphisms (SNPs) so it’s completely unsuitable for looking for this kind of DNA alteration that could be anywhere in the genome.
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#17> the onset of ME/CFS is often associated with viral infections by patients I can personally attest to this. I was an extremely energetic person (shooting straight out of bed in the morning, never requiring daytime naps or rests) until one specific week in April of 1996 when I had what I thought was a mild flu. The post-flu fatigue never really went away. I became acclamatised to it over the years and rarely notice i…
Honestly I feel like I can relate to what you're saying. Hoping as well they find more information regarding this problem soon.
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#18I understand there is an interesting back-story to this paper that will be published in the Washington Post next week. If the findings are replicated (they look promising) we will owe a debt to the patients involved, as well as the researchers, but in particular to the 38 yo index patient with Li Fraumeni syndrome.
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#19There needs to be more research into this horrible disease. There are no yet confirmed biomarkers for it, so doctors dismiss patients as crazy or "making it up." Once there is a biomarker, perhaps like this protein, we can actually start testing treatments to see what works. The scary thing is that there seems to be a vicious path, of COVID->long COVID->ME/CFS. We're not sure what makes COVID evolve into long COVID,…
Just an observational study (FWIW), but microbiome defects could play a role in development of long COVID: https://gut.bmj.com/content/71/3/544
Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME
#20I got long covid in Jan 2022 but after 9 months the neurological symptoms went away. I got sick just this week and the brain fog came back.
Taking probiotics and supplements (omega 3, Multivitamins) and aspirin accelerates the process of getting better for me. I use n-back exercises from Brain Age Concentration Training as measure.