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A New Mode of Cancer Treatment

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191–200 of 215 posts

Re: A New Mode of Cancer Treatment

#191

Wow, sounds like a game changer. A totally different mechanism with almost no effect on healthy cells and it can be used as an adjunct to other chemotherapies? I mean, if it pans out, wow, that would be amazing. I remember reading about how with HIV if you have 1 drug it works for a while but evolves out from under you, 2 drugs extends this time, and a third just flattens it so much there isnt enough popation to muta…

That's the hope. I think Keytruda, aka Pembrolizumab, has also been a game-changer. It can run with other forms of treatment as well.

I hope we're entering a new epoch. The number of people I've met who've lost loved ones too early.

That dragon, cancer. https://en.wikipedia.org/wiki/That_Dragon,_Cancer

Re: A New Mode of Cancer Treatment

#193

Martin Shkreli (yes, that Martin Shkreli) is currently running a virtual screen for additional PCNA inhibitors: https://twitter.com/wagieeacc/status/1687137621699436552

His history is not good.

>> Shkreli bought the exclusive rights to manufacture Daraprim, a drug that can treat a rare parasitic disease, in 2015 and hiked the price from $13.50 per pill to $750, to much controversy. The entrepreneur was ordered in January 2022 to return $64.6 million in profit made by the price hikes and creating what the Federal Trade Commission alleged was “a web of anti-competitive restrictions” to prevent rivals from making a cheaper generic version.

https://www.fastcompany.com/90932968/martin-shkreli-dr-gupta...

Re: A New Mode of Cancer Treatment

#194

Martin Shkreli (yes, that Martin Shkreli) is currently running a virtual screen for additional PCNA inhibitors: https://twitter.com/wagieeacc/status/1687137621699436552

Can you explain what's going on there? Sounds like he's doing something to prevent patenting of drugs but I don't follow what it is.

Virtual screening[1] is a computational technique where you take an experimentally resolved structure of a protein (PCNA in this case) and sequentially dock a large amount of different compounds to see which ones of them bind favorably to the target protein. It is worth mentioning that virtual screening is a very early step in a drug discovery pipeline. These hits need to be characterized and validated experimentally to see if there is an actual effect.

I am not well-versed in intellectual property (so please correct me if I’m wrong), but in this case Shkreli is using a database of commercially available compounds (ZINC) and a hit present in the screen could be patented. He said he won’t do it, and, since this could be considered prior art, nobody else can do a claim.

[1]: https://en.wikipedia.org/wiki/Virtual_screening

Re: A New Mode of Cancer Treatment

#195
post #98

Earlier quoted context omitted.

ChatGPT (instruction tuned autoregressive language models) indeed already seems quite general (it's good at conversation Turing tests without faking it like ELIZA), even if the absolute intelligence is limited. Level of generality and intelligence is not the same. Something could be quite narrow but very intelligent (AlphaGo) or quite general but dumb overall (small kid, insect). Okay, ChatGPT is only text-to-text, b…

> it's good at conversation Turing tests without faking it like ELIZA Just like ELIZA can be said to be faking it, ChatGPT is faking it in a different way.

If ChatGPT is faking it, we are faking it. We are not faking it. Therefore ChatGPT isn't faking it.

Re: A New Mode of Cancer Treatment

#196

Earlier quoted context omitted.

> it's good at conversation Turing tests without faking it like ELIZA Just like ELIZA can be said to be faking it, ChatGPT is faking it in a different way.

If ChatGPT is faking it, we are faking it. We are not faking it. Therefore ChatGPT isn't faking it.

We are not doing the same as ChatGPT. For instance: Because of its training, ChatGPT tries to answer like a human. Humans don't try to answer like a human.

Re: A New Mode of Cancer Treatment

#197
post #126

Earlier quoted context omitted.

What, specifically, is your family seeing? So far there are some troops near the Polish border, and a possible helicopter incursion. There's not a lot that civilions could see unless they lived right on the border.

> possible helicopter incursion It's not a possible. And yes there are people living 'right on the border'.

If I lived on the border, I'd be upset, too. However, this isn't very far from standard Russian way of doing things. They regularly invade air space of various NATO countries, maybe just to test their fighters, maybe to introduce some tension, who knows. The routine is that our fighters escort the intruders back to where they came from. In this case, since the military training was communicated well in advance and the army was expected their aircraft near the border, nobody even bothered. Funnily enough, the last news from Belarus indicate that it might be in fact an accident, not planned action.

Re: A New Mode of Cancer Treatment

#198
post #71

Earlier quoted context omitted.

No, that's just noise generated by the Russians and Belarus and then picked up by the press to make it sound dramatic. This is par for the course for Russian disinfo.

So the Belarus incursion that Belarus denies and the Polish publicly announced response are all Russian disinfo?

The whole story is quite interesting. After Lukashenko falsified the elections (again) and Belorussians went on the streets (for the first time with such an intensity), in the end Lukashenko decided to fight for his life and visited Putin to get his support. After that, the protests were brutally ended, people dead or in prisons, and Lukashenko came from Moscow with full Putin support. But also with two strings attached: the first was organized transport of people from Africa etc. to Minsk and then to the forests near the borders with Poland and Lithuania. The other one was letting Putin use his land for attacks on Ukraine (which backfired in various ways; one of them was the rise of Belorussian resistance movement among railway workers who regularly sabotaged Russian railway transport near the border in Ukraine).

So the interesting question here that many people ask is, what game is Lukashenko playing here? I saw many comments that he just pretends he is stupid but in fact he is quite intelligent and he's doing what he can to keep his country as far away from war as possible. At the same time, he needs some tension and external enemy to help him keep the power (at least among the ~20% of Belorussians who actually believe the official propaganda and support him).

I very much hope I will live long enough to see the day when Belorussians finally get their freedom in a peaceful way and can enjoy living in peace, doing business with other countries and just be happy. I know many of them, they are very nice people, it's such a pity they need to go through this shit.

Re: A New Mode of Cancer Treatment

#199

Earlier quoted context omitted.

If ChatGPT is faking it, we are faking it. We are not faking it. Therefore ChatGPT isn't faking it.

We are not doing the same as ChatGPT. For instance: Because of its training, ChatGPT tries to answer like a human. Humans don't try to answer like a human.

We do try to answer in a way that makes us understood by other humans.

Re: A New Mode of Cancer Treatment

#200
post #146
post #98

Earlier quoted context omitted.

ChatGPT (instruction tuned autoregressive language models) indeed already seems quite general (it's good at conversation Turing tests without faking it like ELIZA), even if the absolute intelligence is limited. Level of generality and intelligence is not the same. Something could be quite narrow but very intelligent (AlphaGo) or quite general but dumb overall (small kid, insect). Okay, ChatGPT is only text-to-text, b…

One distinction I would make is that at true AGI should have internet access and be able to query for updated information, instead of being stuck in the time moment it's trained.

Bing does that all the time.
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