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Scientists may have found mechanism behind cognitive decline in aging

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Re: Scientists may have found mechanism behind cognitive decline in aging

#281

Earlier quoted context omitted.

I really want to know, why don't we all supplement with L-arginine long term? Time-release capsules are available and I have taken for numerous issues like RSI to great success. Whats the downside to long term usage?

Arginine has good short-term endothelial effects but bad long term effects. Most studies last https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069264/

I am skeptical of this because as far as I understand, Arginine is naturally occurring in many foods.

Re: Scientists may have found mechanism behind cognitive decline in aging

#282
post #257

Earlier quoted context omitted.

> A title is not "the most informative and complete sentence summarizing the article", it also has the goal to stimulate curiosity. Are you advocating clickbait?

Why did you italicize a word? Why speak with any emotion ever? Why not focus exclusively on the optimal method of transferring information from one being to another?

In this case, I believe that using italics to convey emphasis and a bit of emotion is the optimal method of transferring information (here, expressing surprise and questioning someone apparently favoring a practice that is generally correctly viewed as a pure negative).

Re: Scientists may have found mechanism behind cognitive decline in aging

#283
post #222

Isn't the mechanism behind anything in aging "entropy"?

How would you turn this theory of aging into some sort of action? This theory means nothing if it can't be tested, if we can't act on it in some way.

Second law of thermodynamics?

Re: Scientists may have found mechanism behind cognitive decline in aging

#284

Earlier quoted context omitted.

Some tell-tale signs (I work with GPT a lot as I mentioned in a sibling comment): - It's a list, it's numbered, it's got pretty consistent markdown formatting. This is especially present with ChatGPT - Title Casing In Each List Item - Strong usage of the passive voice - Strong CYA tone. "might promote", "studies suggest", "has been associated", "can convert", "possibly lowering", "thought to increase" The general str…

Well, considering it was trained from content created from how people actually write, yes?

[deleted]

Re: Scientists may have found mechanism behind cognitive decline in aging

#285

Earlier quoted context omitted.

Some tell-tale signs (I work with GPT a lot as I mentioned in a sibling comment): - It's a list, it's numbered, it's got pretty consistent markdown formatting. This is especially present with ChatGPT - Title Casing In Each List Item - Strong usage of the passive voice - Strong CYA tone. "might promote", "studies suggest", "has been associated", "can convert", "possibly lowering", "thought to increase" The general str…

Well, considering it was trained from content created from how people actually write, yes?

Ah yes, just like how I know most of my american friends have exactly 0.78 kids.

Re: Scientists may have found mechanism behind cognitive decline in aging

#286

Earlier quoted context omitted.

Some tell-tale signs (I work with GPT a lot as I mentioned in a sibling comment): - It's a list, it's numbered, it's got pretty consistent markdown formatting. This is especially present with ChatGPT - Title Casing In Each List Item - Strong usage of the passive voice - Strong CYA tone. "might promote", "studies suggest", "has been associated", "can convert", "possibly lowering", "thought to increase" The general str…

Sure, but hints are not proof. In fact, > Would people actually[] write like this? : some people do. What you call «CYA tone» can overlap with what for others is "precision". It is the quality of the text, then, that hints further to actual intelligence or "artificial struggle".

GPT4 can generate some extraordinarily high quality text if you know how to prompt it. But this ain't it - it's some of the most boring way to prompt. The OP's response is what happens when you prompt with some article summary and a "What are some possible ways we could increase the production of nitric oxide in the body".

And no, that trashy CYA tone is not "precision", if anything, it's vagueness. It's weasel words.

Re: Scientists may have found mechanism behind cognitive decline in aging

#287
post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

Also, get checked up for Sleep Apnea. It is a truly life-ruining condition whose primary side effect is lost memory and cognitive function.

This is one of the most frustrating things about the US. This shit is expensive. Sure, for a lot of us making bank in the software field we tend to lose sight of that. I got laid off (yay hyper-capitalist bonus chasing management). I'm reading this thread and seeing plenty of things that would be great from a health perspective but let's be real. They're all out of reach for me. Fortunately, that's temporary for myself. I'm sure I'll be back to making bank within a year or two. Most folks however? This advice will permanently be out of reach.

Re: Scientists may have found mechanism behind cognitive decline in aging

#288
post #136
post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

I had the same after COVID. Took me many months to start feeling functional again. Any time I tried to think about something, it'd just... noise out? First 2-3 months were just awful I went to a neurologist who said there's tons of people coming in with the same complaint after COVID, and since there's no literature on that yet, he couldn't really do anything. It gets better.

I assure you that there is literature on it. Here’s an almost random sample of papers.

https://doi.org/10.1016/j.neuron.2022.10.006

https://doi.org/10.1007%2Fs10238-022-00871-8

https://doi.org/10.1016/j.nerep.2022.100154

https://doi.org/10.1042/BCJ20220016

I would like to point to this kind of statement that doctors often make, that there is “no literature” or that “nothing is known”. This is very often flat out wrong. Consider the size of the statement: Nothing is known and there exists no literature. The domain of knowledge required for the statement is omniscience. Having read all papers. It’s not an acceptable statement for anyone to make.

Re: Scientists may have found mechanism behind cognitive decline in aging

#289
post #136

Earlier quoted context omitted.

I had the same after COVID. Took me many months to start feeling functional again. Any time I tried to think about something, it'd just... noise out? First 2-3 months were just awful I went to a neurologist who said there's tons of people coming in with the same complaint after COVID, and since there's no literature on that yet, he couldn't really do anything. It gets better.

I wonder how many people just fell into alcohol, isolation induced depression, sedentary lifestyle, weight gain, etc... and that their health decline had nothing to do with COVID. That's the issue with these anecdotes

Please forgive me for turning your words back on you: The issue with these statements such as yours is that they assume the non-existence of evidence that confirms that people’s experience is real.

https://doi.org/10.1016/j.neuron.2022.10.006

SARS-CoV-2 is known to cause brain damage, endocrine problems, and circulatory issues which impede oxygenation. Of the brain.

Re: Scientists may have found mechanism behind cognitive decline in aging

#290

Earlier quoted context omitted.

Sure, but hints are not proof. In fact, > Would people actually[] write like this? : some people do. What you call «CYA tone» can overlap with what for others is "precision". It is the quality of the text, then, that hints further to actual intelligence or "artificial struggle".

GPT4 can generate some extraordinarily high quality text if you know how to prompt it. But this ain't it - it's some of the most boring way to prompt. The OP's response is what happens when you prompt with some article summary and a "What are some possible ways we could increase the production of nitric oxide in the body". And no, that trashy CYA tone is not "precision", if anything, it's vagueness. It's weasel words…

> no, that trashy CYA tone is not "precision", if anything, it's vagueness. It's weasel words

That is not what I said. /That/ «trashy CYA tone is not "precision"». But some use similar expressions to those you noted in order to be factual.

Some texts give a strong impression of fakery; some texts could give a wrong impression upon brutal use of raw Bayesian indicators. Signs orient, do not decide. Hints are not proof.

Some patterns in LLM output can be caricatures of proper efforts (factuality for precision, when relevant, is one of them).

So, people may write similarly to that. (Only, hopefully, well beyond veneer.)

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