Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Scientists may have found mechanism behind cognitive decline in aging

news.cuanschutz.edu

Post reply on HN
Print view View original

61–70 of 314 posts

Re: Scientists may have found mechanism behind cognitive decline in aging

#62

Post by mellosouls »

Etheryte wrote: post #4

...in mice.

I saw this report the other day and didn't submit it here because of "...in mice". I mean I agree with your comment btw.

We probably need a standard bracket suffix like (in mice) for these sorts of things, as we do for year.

Re: Scientists may have found mechanism behind cognitive decline in aging

#64

Post by patapong »

PaulKeeble wrote: post #21
Aaargh20318 wrote: post #7

Earlier quoted context omitted.

Due to the way medication is developed, we basically only end up with medicine that works on humans + at least one other species. I wonder how many medications we have missed out on that would have worked on humans but never got to the human trial stage because it doesn’t work in any of the animal models we use.

And a condition we can induce in another animal. If we can't cause it in another animal then we can't test a drug against it. There are a lot of diseases that can make no progress under this model which we can not induce in animals or humans.

Fascinating! Reminds me how machine learning as a field is often focused on tasks that can be quantitatively evaluated using large datasets. There are a lot of tasks that do not fit this model, especially interactive tasks.

Re: Scientists may have found mechanism behind cognitive decline in aging

#67

Post by criddell »

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

You might want to research Nicotinamide Riboside. I started taking it to see if it would help with painful inflammation in my hands, wrists, and knees and noticed that when I take it, not only is inflammation improved, but my sleep improved (I track with an Oura ring) and I can concentrate for longer periods of time.

Might all be placebo effect, but I’m okay with that. My doctor seems to think that’s probably the case.

FWIW, I’m 20 years older than you.

Re: Scientists may have found mechanism behind cognitive decline in aging

#68

Post by salad-tycoon »

jeffybefffy519 wrote: post #43
submeta wrote: post #35

[flagged]

I really want to know, why don't we all supplement with L-arginine long term? Time-release capsules are available and I have taken for numerous issues like RSI to great success. Whats the downside to long term usage?

Side bar : L citrulline is thought to be more effective than arginine.

One downside that I don’t see discussed much, as I’ve watched multiple recalls over recent years for supposed contamination of things like tmao and other toxins in either the manufacturing process or packaging process, I wonder how many supplements are contaminated. I have never seen an analysis even from the vendors who do pretty hefty chemical composition analysis.

Re: Scientists may have found mechanism behind cognitive decline in aging

#70

Post by galenko »

andy_ppp wrote: post #52
submeta wrote: post #35

[flagged]

> Cautious Mouthwash Use: I was under the impression that poor dental hygiene is associated with Alzheimer's disease and dementia?

There’s poor dental hygiene and then there is nuking all the bacteria in your mouth with mouthwash.

You can have perfect dental hygiene and never use mouth wash in your life.

Just cause companies like selling you a product, doesn’t mean it’s good for you.

Post reply on HN