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Alcohol without the hangover – scientists are finding ways

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Re: Alcohol without the hangover – scientists are finding ways

#221

Post by klardotsh »

coldtea wrote: post #181
klardotsh wrote: post #155

Earlier quoted context omitted.

Alcohol and caffeine are the only two drugs I can think of (okay, in some circles maybe cannabis too) where the response to "I cut this thing out of my life" is often "why?" or "you know you could still do a little?" One exercise to illustrate the ridiculousness and disrespect of phrases like that is to replace "alcohol" with "crack". "I don't do crack anymore" would basically never be responded to with "you know, yo…

> One exercise to illustrate the ridiculousness and disrespect of phrases like that is to replace "alcohol" with "crack". Or replace it with "oxygen" and see how ridiculous it is to suggest absteining from it. See how bad analogies cut both ways?

Yes, it's ridiculous to suggest abstaining from a thing that all known living entities on Earth require for sustenance. I'll give you a hint: that thing is not ethanol. And besides, nobody's saying, by saying "I don't do alcohol anymore", that YOU can't down all the Everclear you want, so I have no idea where this overly-defensive comment came from.

Re: Alcohol without the hangover – scientists are finding ways

#222

Post by serf »

ramraj07 wrote: post #216
01100011 wrote: post #196

There are many other alcohols, 2M2B( https://en.wikipedia.org/wiki/Tert-Amyl_alcohol ) for example, which are "alcohol without the hangover" in a sense. I seem to remember a scientist looking into ways to deliver these alcohols(absorbed in cellulose IIRC). You'll note that these chemicals, like alcohol, can also lead to overdoses and since they are much more potent it is even more difficult to ensure one does not ove…

I hope you can see that your friends are alcoholics. Drinking 18 of any alcoholic drink shouldn't be considered normal as much as the surroundings might indicate otherwise.

it's not normal in the base-line average manner of speech, but it's common. 17 percent of American men have binge-drank in their past year.[0]

another point : a single anecdote about someone binge drinking is by no means the single qualified indicator for alcoholism. alcoholism is a specific set of mental and physical traits which all orbit the most common traits of uncontrollability and preoccupation/addiction.

a single binge drinking episode isn't smart or healthy; and it may indicate something as part of a broader trend, but it's not a good indicator of whether or not someone is an alcoholic.

[0]: https://magazine.medlineplus.gov/article/how-much-is-too-muc...

Re: Alcohol without the hangover – scientists are finding ways

#223

Post by ChatGTP »

dgb23 wrote: post #33
1ba9115454 wrote: post #10

I've switched to alcohol free beers. They're a bit sweeter but for me it's fine.

I like drinking a beer or two sometimes during the week. It’s tasty, cool and calming. Alcohol free beer is great for that. However most alcohol free beers don’t taste nice. Takes a bit of shopping around to find a brand that doesn’t taste like Ovomaltine.

You might already know this but a lot of no-alcohol beers are also low or no carb and they contain artificial sweetener to make them test better.

I been having no-alcohol beer with some sugar in it (93 cals a bottle). It's way way more tasty.

Re: Alcohol without the hangover – scientists are finding ways

#224

Post by klardotsh »

hnick wrote: post #191
klardotsh wrote: post #155

Earlier quoted context omitted.

Alcohol and caffeine are the only two drugs I can think of (okay, in some circles maybe cannabis too) where the response to "I cut this thing out of my life" is often "why?" or "you know you could still do a little?" One exercise to illustrate the ridiculousness and disrespect of phrases like that is to replace "alcohol" with "crack". "I don't do crack anymore" would basically never be responded to with "you know, yo…

The difference is that it's legal and widely enjoyed by others. Cigarettes are too but there's been a widespread shift in public opinion meaning this doesn't occur. You'll sometimes see the same stuff said if someone announces they are vegetarian or made another dietary change.

I did the trifecta in the past year of cutting alcohol (still on an indefinite break from that), caffeine (my 7 months sans-caffeine has now ended due to lack of many positive changes; may as well allow myself a Coke every so often if I want), and meat (3mos and counting), so yeah, I definitely get it. I've had inquisitive eyebrow-raises at all three, though fewer of them the more things I changed (folks just started assuming I was in a Trying New Things time, thankfully)

Re: Alcohol without the hangover – scientists are finding ways

#225

Post by ChatGTP »

CommanderData wrote: post #170

Don't all types of alcohol damage cells, so a type that has no apparent after effects but the 'high' per se would cause people to consume even more. Why is this a good thing? Andrew Huberman did a pretty in depth podcast covering many things alcohol does to the body, masking it's apparent Ill effects can't be a good thing.

I thought the same thing, the hangover is a major deterrent for me. If that is taken away I think people are just going to drink much more and make themselves sicker.

Re: Alcohol without the hangover – scientists are finding ways

#226

Post by photonbeam »

ramraj07 wrote: post #216
01100011 wrote: post #196

There are many other alcohols, 2M2B( https://en.wikipedia.org/wiki/Tert-Amyl_alcohol ) for example, which are "alcohol without the hangover" in a sense. I seem to remember a scientist looking into ways to deliver these alcohols(absorbed in cellulose IIRC). You'll note that these chemicals, like alcohol, can also lead to overdoses and since they are much more potent it is even more difficult to ensure one does not ove…

I hope you can see that your friends are alcoholics. Drinking 18 of any alcoholic drink shouldn't be considered normal as much as the surroundings might indicate otherwise.

I highly doubt anyone is misleading themselves

Re: Alcohol without the hangover – scientists are finding ways

#227

Post by [deleted] »

boomskats wrote: post #102

I've had a subscription to David Nutt's Sentia Spirits [0] for a few months, which uses an extract from GABA Labs. I enjoy the mild effect and I do think they're onto something, but I have to mix it as it tastes a bit soapy (that's the red, I've yet to try sentia black). I like the idea that the subscription to Sentia funds the development of Alcarelle (the product mentioned in the article), but the overwhelming reas…

[deleted]

Re: Alcohol without the hangover – scientists are finding ways

#229

Post by reaperman »

Helmut10001 wrote: post #32
bluefishinit wrote: post #4

I love my IPAs but I have to admit that the UK does social beer right. 3% or even 2.5% ales are the way to go if you want to socially drink. We have a concept of a "session" beer in the US, which is lower ABV but the selection of really good, really low gravity beers is the best in the UK as far as I can tell.

I really like Full Sail Session IPA, every time I visit the US I get some. Germany is really lacking behind this hole development, the beer is just very poor these days here.

Belgium produces many incredible beers that outshine American beers and should be easily found in Germany. I’m a massive fan of American beers but Belgium always gets my voice of support as well.

Re: Alcohol without the hangover – scientists are finding ways

#230

Post by Scoundreller »

jimmydef wrote: post #218

As someone with severe Asian flush, with an overactive ADH gene (gene that converts of alcohol to acetaldehyde) and 2 defective ALDH2 alleles (gene that breaks down acetaldehyde into harmless byproducts), I wish there is a way to repair these genes using MRNA. I don't feel even the mildest buzz from alcohol but I instantly get a hangover when I drink.

mRNA injections won't do it. You'd need a CRISPR for that. And someway to get the rest of your body to take up the cells with the new genes, and you're a little late for most of your cells. I think you're better off searching for non-alcoholic alternatives in the short-medium term.
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