I wonder what the impact of this is on tinnitus.
Are you implying that metformin could be a tinnitus treatment?
Metformin shown to prevent long Covid
181–190 of 195 posts
Re: Metformin shown to prevent long Covid
#182Earlier quoted context omitted.
Metformin is looking like the aspirin of the 21st century.
Nir Barzilai and a team of researchers are leading a large clinical trial to test the benefits of metformin in slowing the aging process, which is upstream of so many diseases that yeah, it could just be a cheap cure-all. Sadly requires a prescription in the US. But berberine is the off-the-shelf equivalent. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347426/
Yeah agreed. Is berberine really an equivalent though if the mechanisms are different and the not knowing metformin’s complete mechanism although it has a pleitropic effect? Metformin is heavily studied in comparison too.
Re: Metformin shown to prevent long Covid
#183Earlier quoted context omitted.
"impregnate" is not wrong per-se, but it is weird in placing the emphasis on only one of the two people required. Usually you'd say something like "trying for a child", I believe.
It's not weird in this case, because the drug specifically affects male sperm, and it's the man who impregnates the woman.
It's weird regardless of the drug.
Re: Metformin shown to prevent long Covid
#184Re: Metformin shown to prevent long Covid
#185Earlier quoted context omitted.
Multiple-vaccinated or has had Covid? Why only those two options? I and a big portion of my circle is unvaccinated, healthy and didn't have Covid.
Unless you've been continually tested every 2 weeks for the past 3 years you might very well have had it asymptomatically
Let's add in, for the obvious fun, that the rate of asymptomatic infection is lower than the false positive rate of tests.
Re: Metformin shown to prevent long Covid
#186Interesting, I wonder if this could help Dianna Cowern (Physics Girl on YouTube) who has been diagnosed with long COVID leading to ME/CFS.
I also wondered whether this could be a treatment for long covid. I don't know enough about it's etiology to say; however, like you I was downvoted without any response. Which is sad and not constructive.
Re: Metformin shown to prevent long Covid
#187Earlier quoted context omitted.
Derek Lowe has a good discussion as well: https://www.science.org/content/blog-post/long-covid-shows-c... One thing to point out--this study provides the first really solid evidence that Long Covid actually exists. From Derek Lowe: "An overarching point, though, is made in a valuable commentary in the same issue of the Lancet by Jeremy Samuel Faust: this effect against a placebo control really shows us that there is…
There are literally thousands of studies about long COVID- unless you believe they were all hallucinations by people who shouldn't be in academia, this is very much so not the "first" really solid evidence. I've seen evidence of increased all-cause mortality, arterial stiffness, reduced physical fitness, and much, much more. All of which is in the first place only necessary because a core pillar of healthcare is the…
> There are literally thousands of studies about long COVID
But none of them had a placebo group as far as I know.
If another one did, I'd love a reference.
Re: Metformin shown to prevent long Covid
#188Earlier quoted context omitted.
Parent is saying it's the first evidence of TREATMENT. Incidentally, my bet is that many other viruses and bacteria have similar post acute symptoms. I wonder if these can also be measured and treated, perhaps even with metformin. I wonder how much of metformin's magical anti aging capabilities are actually due to fighting off latent infections.
I don't know about bacteria, but post viral syndrome has been measured for decades with other viruses. https://pubmed.ncbi.nlm.nih.gov/3320358/ Metformin doesn't have any "magical" anti-aging properties. It is effective for treating certain metabolic conditions such as type-2 diabetes but it has never been proven to extend lifespan in otherwise healthy humans (or any other higher primate). There are some significant…
I meant the magical part as tongue in cheek. I guess that doesn't come across well in text. My conjecture is that the anecdotal or limited evidence could be conflated with an improvement of latent infections, which would be an inconsistent effect.
Re: Metformin shown to prevent long Covid
#189Earlier quoted context omitted.
Yes, a prophylactic treatment. I think my point stands, semantics aside.
It's not the first evidence of treatment and preventing isn't the same as treating, because it does nothing for people who have the disease.
Can you share prior evidence of effective treatment? It's the first I've heard of it, and obviously the same goes for parent poster.
I understand the distinction you are making, and that's why I said semantics aside.
Re: Metformin shown to prevent long Covid
#190Interesting, I wonder if this could help Dianna Cowern (Physics Girl on YouTube) who has been diagnosed with long COVID leading to ME/CFS.
I also wondered whether this could be a treatment for long covid. I don't know enough about it's etiology to say; however, like you I was downvoted without any response. Which is sad and not constructive.
True. I was hoping for a conversation about it, but never mind.