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Metformin shown to prevent long Covid

cidrap.umn.edu

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Re: Metformin shown to prevent long Covid

#71

Post by r0l1 »

gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

Multiple-vaccinated or has had Covid? Why only those two options? I and a big portion of my circle is unvaccinated, healthy and didn't have Covid.

Re: Metformin shown to prevent long Covid

#72

Post by kramerger »

carlmr wrote: post #49
gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated ~or~ and has had COVID multiple times Isn't this the most common demographic?

Not in places were vaccine rollout was quick and frictionless with good coverage, thus reducing probability of transmission of the main strain and early mutations.

I think a lot of people in Northern Europe have either never had covid or had a mild possibly unnoticeable infection

Re: Metformin shown to prevent long Covid

#73

Post by azangru »

r0l1 wrote: post #71
gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

Multiple-vaccinated or has had Covid? Why only those two options? I and a big portion of my circle is unvaccinated, healthy and didn't have Covid.

A big portion? Wow. I thought no-one escaped omicron BA.2

Re: Metformin shown to prevent long Covid

#74

Post by rbanffy »

sBqQu3U0wH wrote: post #57
petecooper wrote: post #52

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

There is a small risk of developing myocarditis after being vaccinated, but the risk of dying of COVID in the US, for instance, was of 1.1% after being diagnosed.

I’m really sorry you are going through this. People didn’t have time to better test the vaccines to ensure their safety before having to use them to prevent massive loss of life due to the disease.

Perhaps we’ll find ways to alleviate the issues the vaccines caused, or even fix them, as the number of cases is significant and, with that, they can be better studied and the mechanisms better understood.

Re: Metformin shown to prevent long Covid

#75

Post by ethanbond »

darkerside wrote: post #66
hilbertseries wrote: post #47

Earlier quoted context omitted.

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-tripl...

Parent is saying it's the first evidence of TREATMENT. Incidentally, my bet is that many other viruses and bacteria have similar post acute symptoms. I wonder if these can also be measured and treated, perhaps even with metformin. I wonder how much of metformin's magical anti aging capabilities are actually due to fighting off latent infections.

They’re quite clearly saying that the effectiveness of the treatment is actually “the first” solid evidence of the disease.

Which is wrong, it’s not the first, but it is also pretty darn good evidence to add to the pile, so it’s not that wrong. It’s just the evidence that appears to have convinced GP, which is cool to see happen in real time!

Re: Metformin shown to prevent long Covid

#76

Post by r0l1 »

azangru wrote: post #73
r0l1 wrote: post #71

Earlier quoted context omitted.

Multiple-vaccinated or has had Covid? Why only those two options? I and a big portion of my circle is unvaccinated, healthy and didn't have Covid.

A big portion? Wow. I thought no-one escaped omicron BA.2

Can't say too much about it. Didn't really follow the whole Covid discussion and just continued my lifestyle. Eating healthy (fresh self-made food), doing sports and looking after a good mental state. Family and my circle did the same. Friends who have been vaccinated got Covid several times. But are also good now... My grandmom (89 years), also unvaccinated, didn't get Covid. Her sister got it (vaccinated). Both healthy now... Just let everybody do their own thing... The whole hate in the communities was unnecessary.

Re: Metformin shown to prevent long Covid

#77

Post by notacoward »

sBqQu3U0wH wrote: post #57
petecooper wrote: post #52

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

> may be due to the vaccination

Emphasis on may, or might. Your experience is certainly valid, and I'm sorry you have to go through this, but it's still a sample of one with no theory of causation. If a certain percentage of people are vaccinated, and a certain percentage of people develop heart problems regardless of vaccination, a few of those people will develop those problems immediately after vaccination. Such things can be just statistical accidents. If I developed heart problems at 58, after years of poor diet and other bad habits, I don't think I'd ascribe it to one discrete recent event unless I was predisposed to believe that the two were related. Therefore, I think it's worth asking: did (or do) you have any such predisposition?

Re: Metformin shown to prevent long Covid

#78

Post by op00to »

r0l1 wrote: post #76
azangru wrote: post #73

Earlier quoted context omitted.

A big portion? Wow. I thought no-one escaped omicron BA.2

Can't say too much about it. Didn't really follow the whole Covid discussion and just continued my lifestyle. Eating healthy (fresh self-made food), doing sports and looking after a good mental state. Family and my circle did the same. Friends who have been vaccinated got Covid several times. But are also good now... My grandmom (89 years), also unvaccinated, didn't get Covid. Her sister got it (vaccinated). Both hea…

Did you get a test to see if you actually avoided Covid?

Re: Metformin shown to prevent long Covid

#79

Post by mojosam »

thenerdhead wrote: post #8

Does it help those with long Covid?

The claim is that metformin greatly reduces viral load. If your long COVID is caused by the virus continuing to linger on 8n some tissues, as there is evidence might be the case for s9me patience, then it might. But if your long COVID is caused by microclots or lung scarring or other physiological damage caused by COVID, then no.

Re: Metformin shown to prevent long Covid

#80

Post by r0l1 »

op00to wrote: post #78
r0l1 wrote: post #76

Earlier quoted context omitted.

Can't say too much about it. Didn't really follow the whole Covid discussion and just continued my lifestyle. Eating healthy (fresh self-made food), doing sports and looking after a good mental state. Family and my circle did the same. Friends who have been vaccinated got Covid several times. But are also good now... My grandmom (89 years), also unvaccinated, didn't get Covid. Her sister got it (vaccinated). Both hea…

Did you get a test to see if you actually avoided Covid?

We did normal Covid tests for work. Maybe I should do an antibody test. Would be interesting...
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